Can adipokines predict clinical prognosis and post-COVID lung sequelae?

Can adipokines predict clinical prognosis and post-COVID lung sequelae?

Adipokines play an important role in the regulation of inflammatory responses toward infections, including COVID-19. This study aimed to investigate the role of chemerin, adiponectin, and leptin in prognosis and post-COVID lung sequelae in hospitalized patients with COVID-19. Serum levels of the thr...

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Veröffentlicht in:Respiratory investigation 2023-09, Vol.61 (5), p.618-624
Hauptverfasser: Esendagli, Dorina, Topcu, Deniz, Gul, Eylem, Alperen, Cansu, Sezer, Rahime, Erol, Cigdem, Akcay, Sule
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Adipokine
Biomarker
COVID-19
Lung
Prognosis
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container_end_page 624
container_issue 5
container_start_page 618
container_title Respiratory investigation
container_volume 61
creator Esendagli, Dorina
Topcu, Deniz
Gul, Eylem
Alperen, Cansu
Sezer, Rahime
Erol, Cigdem
Akcay, Sule
description Adipokines play an important role in the regulation of inflammatory responses toward infections, including COVID-19. This study aimed to investigate the role of chemerin, adiponectin, and leptin in prognosis and post-COVID lung sequelae in hospitalized patients with COVID-19. Serum levels of the three adipokines were measured upon admission of polymerase chain reaction-confirmed patients with COVID-19 who were followed up for 6 months for the clinical outcome and lung sequelae formation. A total of 77 patients were included in the study. Of the 77 patients, 58.4% were males, and the median age was 63.2 ± 18.3 years. Fifty-one patients (66.2%) had a good prognosis. Among adipokines, only chemerin was significantly lower in the bad prognosis group (P 
doi_str_mv 10.1016/j.resinv.2023.06.001
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This study aimed to investigate the role of chemerin, adiponectin, and leptin in prognosis and post-COVID lung sequelae in hospitalized patients with COVID-19. Serum levels of the three adipokines were measured upon admission of polymerase chain reaction-confirmed patients with COVID-19 who were followed up for 6 months for the clinical outcome and lung sequelae formation. A total of 77 patients were included in the study. Of the 77 patients, 58.4% were males, and the median age was 63.2 ± 18.3 years. Fifty-one patients (66.2%) had a good prognosis. Among adipokines, only chemerin was significantly lower in the bad prognosis group (P &lt; 0.05), and the serum levels showed a negative correlation with age (rho = −0.238; P &lt; 0.05). Leptin levels were negatively correlated with gamma glutamyl transferase levels, which were significantly higher in the bad prognostic group (rho = −0.240; P &lt; 0.05). Twenty-four patients had no lung sequelae, and 20 developed sequelae within 6 months after infection. Chemerin/adiponectin ratio with a cut-off value of 0.96 and an area under the curve 0.679 (P &lt; 0.05) might predict the sequelae formation. Chemerin levels are lower, especially in patients with a bad prognosis, and the chemerin/adiponectin ratio might predict the development of lung sequelae in patients with COVID-19.</description><identifier>ISSN: 2212-5345</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2023.06.001</identifier><identifier>PMID: 37433250</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adipokine ; Biomarker ; COVID-19 ; Lung ; Prognosis</subject><ispartof>Respiratory investigation, 2023-09, Vol.61 (5), p.618-624</ispartof><rights>2023 The Japanese Respiratory Society</rights><rights>Copyright © 2023 The Japanese Respiratory Society. Published by Elsevier B.V. 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subjects Adipokine
Biomarker
COVID-19
Lung
Prognosis
title Can adipokines predict clinical prognosis and post-COVID lung sequelae?
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