Graft-versus-host disease is associated with skewed γδ T-cell clonality after umbilical cord blood transplantation in children with nonmalignant diseases

The γδ T-cells (GDT) are a subpopulation of lymphocytes expressing a distinct T-cell receptor coded by the TRG and TRD genes. GDTs may have immunoregulatory function after stem cell transplantation (SCT), but the relationship between GDT clonality and acute graft-versus-host disease (aGVHD) is not k...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2023-10, Vol.25 (10), p.1091-1100
Hauptverfasser:	Winstead, Mike, Hill, Memphis, Amin, Zarreen, Lugt, Mark Vander, Chen, Xiaohua, Szabolcs, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	cord blood gamma delta graft-versus-host disease immune reconstitution pediatric stem cell transplantation T cell
Online-Zugang:	Volltext
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