In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled
Children with intestinal failure without liver disease may be given soy-based lipid emulsion (SLE) or mixed lipid emulsion (MLE; containing soy, medium-chain triglyceride, olive, and/or fish oils). Both differ in essential fatty acid content: MLE has added arachidonic acid (AA) and docosahexaenoic a...
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| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 2023-11, Vol.47 (8), p.1038-1046 |
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| container_title | JPEN. Journal of parenteral and enteral nutrition |
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| creator | Pauline, Mirielle L Huynh, Caitlin Wizzard, Pamela R Nation, Patrick N Field, Catherine J Wales, Paul W Turner, Justine M |
| description | Children with intestinal failure without liver disease may be given soy-based lipid emulsion (SLE) or mixed lipid emulsion (MLE; containing soy, medium-chain triglyceride, olive, and/or fish oils). Both differ in essential fatty acid content: MLE has added arachidonic acid (AA) and docosahexaenoic acid (DHA). The aim of this study, in neonatal piglets, was to compare serum and tissue fatty acid composition when the emulsions were given at unrestricted doses.
We compared SLE (n = 15) and MLE (n = 15) at doses of 10-15 g/kg/day in parenteral nutrition (PN). On day 14 we collected serum and tissues. Using gas-liquid chromatography, percentage fatty acids were measured in serum, brain, and liver phospholipid. Comparisons were made to reference values from litter-matched controls (n = 8).
Comparing median values, linoleic acid (LA) was lower for MLE vs SLE in serum (-27%), liver (-45%), and brain (-33%) (P |
| doi_str_mv | 10.1002/jpen.2547 |
| format | Article |
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We compared SLE (n = 15) and MLE (n = 15) at doses of 10-15 g/kg/day in parenteral nutrition (PN). On day 14 we collected serum and tissues. Using gas-liquid chromatography, percentage fatty acids were measured in serum, brain, and liver phospholipid. Comparisons were made to reference values from litter-matched controls (n = 8).
Comparing median values, linoleic acid (LA) was lower for MLE vs SLE in serum (-27%), liver (-45%), and brain (-33%) (P < 0.001). AA was lower for MLE in serum (-25%), liver (-40%), and brain (-10%). DHA was higher for MLE in serum (+50%), liver (+200%), and brain (+10%). AA levels were lower for MLE vs control piglets in serum (-81%), liver (-63%), and brain (-9%). DHA levels were higher in serum (+41%), liver (+38%), and brain (+19%).
This study in piglets has shown that, at unrestricted doses, MLE treatment is associated with low serum and tissue AA compared with SLE and healthy litter-matched controls. Although not yet proven, low tissue AA levels may have functional consequences, and these data support current practice avoiding MLE dose restriction.</description><identifier>ISSN: 0148-6071</identifier><identifier>EISSN: 1941-2444</identifier><identifier>DOI: 10.1002/jpen.2547</identifier><identifier>PMID: 37416983</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arachidonic Acid ; Child ; Docosahexaenoic Acids ; Fat Emulsions, Intravenous - chemistry ; Fatty Acids ; Fatty Acids, Essential ; Fish Oils - chemistry ; Humans ; Parenteral Nutrition - methods ; Phospholipids ; Soybean Oil ; Swine</subject><ispartof>JPEN. Journal of parenteral and enteral nutrition, 2023-11, Vol.47 (8), p.1038-1046</ispartof><rights>2023 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c280t-8cfb13f812e052a97caddf012d1011839aeafd6e7678bb348577bb55a81c194f3</cites><orcidid>0000-0001-7206-735X ; 0000-0001-8700-0035</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37416983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pauline, Mirielle L</creatorcontrib><creatorcontrib>Huynh, Caitlin</creatorcontrib><creatorcontrib>Wizzard, Pamela R</creatorcontrib><creatorcontrib>Nation, Patrick N</creatorcontrib><creatorcontrib>Field, Catherine J</creatorcontrib><creatorcontrib>Wales, Paul W</creatorcontrib><creatorcontrib>Turner, Justine M</creatorcontrib><title>In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled</title><title>JPEN. Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>Children with intestinal failure without liver disease may be given soy-based lipid emulsion (SLE) or mixed lipid emulsion (MLE; containing soy, medium-chain triglyceride, olive, and/or fish oils). Both differ in essential fatty acid content: MLE has added arachidonic acid (AA) and docosahexaenoic acid (DHA). The aim of this study, in neonatal piglets, was to compare serum and tissue fatty acid composition when the emulsions were given at unrestricted doses.
We compared SLE (n = 15) and MLE (n = 15) at doses of 10-15 g/kg/day in parenteral nutrition (PN). On day 14 we collected serum and tissues. Using gas-liquid chromatography, percentage fatty acids were measured in serum, brain, and liver phospholipid. Comparisons were made to reference values from litter-matched controls (n = 8).
Comparing median values, linoleic acid (LA) was lower for MLE vs SLE in serum (-27%), liver (-45%), and brain (-33%) (P < 0.001). AA was lower for MLE in serum (-25%), liver (-40%), and brain (-10%). DHA was higher for MLE in serum (+50%), liver (+200%), and brain (+10%). AA levels were lower for MLE vs control piglets in serum (-81%), liver (-63%), and brain (-9%). DHA levels were higher in serum (+41%), liver (+38%), and brain (+19%).
This study in piglets has shown that, at unrestricted doses, MLE treatment is associated with low serum and tissue AA compared with SLE and healthy litter-matched controls. Although not yet proven, low tissue AA levels may have functional consequences, and these data support current practice avoiding MLE dose restriction.</description><subject>Animals</subject><subject>Arachidonic Acid</subject><subject>Child</subject><subject>Docosahexaenoic Acids</subject><subject>Fat Emulsions, Intravenous - chemistry</subject><subject>Fatty Acids</subject><subject>Fatty Acids, Essential</subject><subject>Fish Oils - chemistry</subject><subject>Humans</subject><subject>Parenteral Nutrition - methods</subject><subject>Phospholipids</subject><subject>Soybean Oil</subject><subject>Swine</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEYRoMotlYXvoBkqeDU3GaSWUrxUii40Y2bITP5IymZi0lG6Ns7pdXVtzl8cA5C15QsKSHsYTtAt2S5kCdoTktBMyaEOEVzQoXKCiLpDF3EuCWE8IKQczTjUtCiVHyOPtcdHnSALkHQHndjCi65vsssGDy4Lw8p3mOrU9ph3TgT8Y8OO1zvsHeDMxja0ceJx7ozOLkYR8BRt4MHc4nOrPYRro67QB_PT--r12zz9rJePW6yhimSMtXYmnKrKAOSM13KRhtjCWWGEkoVLzVoawqQhVR1zYXKpazrPNeKNpOs5Qt0e_gdQv89QkxV62ID3usO-jFWTPGcyZKLckLvDmgT-hgD2GoIrp2EKkqqfcpqn7Lap5zYm-PtWLdg_sm_dvwXtadv8Q</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Pauline, Mirielle L</creator><creator>Huynh, Caitlin</creator><creator>Wizzard, Pamela R</creator><creator>Nation, Patrick N</creator><creator>Field, Catherine J</creator><creator>Wales, Paul W</creator><creator>Turner, Justine M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7206-735X</orcidid><orcidid>https://orcid.org/0000-0001-8700-0035</orcidid></search><sort><creationdate>202311</creationdate><title>In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled</title><author>Pauline, Mirielle L ; Huynh, Caitlin ; Wizzard, Pamela R ; Nation, Patrick N ; Field, Catherine J ; Wales, Paul W ; Turner, Justine M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-8cfb13f812e052a97caddf012d1011839aeafd6e7678bb348577bb55a81c194f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Arachidonic Acid</topic><topic>Child</topic><topic>Docosahexaenoic Acids</topic><topic>Fat Emulsions, Intravenous - chemistry</topic><topic>Fatty Acids</topic><topic>Fatty Acids, Essential</topic><topic>Fish Oils - chemistry</topic><topic>Humans</topic><topic>Parenteral Nutrition - methods</topic><topic>Phospholipids</topic><topic>Soybean Oil</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pauline, Mirielle L</creatorcontrib><creatorcontrib>Huynh, Caitlin</creatorcontrib><creatorcontrib>Wizzard, Pamela R</creatorcontrib><creatorcontrib>Nation, Patrick N</creatorcontrib><creatorcontrib>Field, Catherine J</creatorcontrib><creatorcontrib>Wales, Paul W</creatorcontrib><creatorcontrib>Turner, Justine M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pauline, Mirielle L</au><au>Huynh, Caitlin</au><au>Wizzard, Pamela R</au><au>Nation, Patrick N</au><au>Field, Catherine J</au><au>Wales, Paul W</au><au>Turner, Justine M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>2023-11</date><risdate>2023</risdate><volume>47</volume><issue>8</issue><spage>1038</spage><epage>1046</epage><pages>1038-1046</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><abstract>Children with intestinal failure without liver disease may be given soy-based lipid emulsion (SLE) or mixed lipid emulsion (MLE; containing soy, medium-chain triglyceride, olive, and/or fish oils). Both differ in essential fatty acid content: MLE has added arachidonic acid (AA) and docosahexaenoic acid (DHA). The aim of this study, in neonatal piglets, was to compare serum and tissue fatty acid composition when the emulsions were given at unrestricted doses.
We compared SLE (n = 15) and MLE (n = 15) at doses of 10-15 g/kg/day in parenteral nutrition (PN). On day 14 we collected serum and tissues. Using gas-liquid chromatography, percentage fatty acids were measured in serum, brain, and liver phospholipid. Comparisons were made to reference values from litter-matched controls (n = 8).
Comparing median values, linoleic acid (LA) was lower for MLE vs SLE in serum (-27%), liver (-45%), and brain (-33%) (P < 0.001). AA was lower for MLE in serum (-25%), liver (-40%), and brain (-10%). DHA was higher for MLE in serum (+50%), liver (+200%), and brain (+10%). AA levels were lower for MLE vs control piglets in serum (-81%), liver (-63%), and brain (-9%). DHA levels were higher in serum (+41%), liver (+38%), and brain (+19%).
This study in piglets has shown that, at unrestricted doses, MLE treatment is associated with low serum and tissue AA compared with SLE and healthy litter-matched controls. Although not yet proven, low tissue AA levels may have functional consequences, and these data support current practice avoiding MLE dose restriction.</abstract><cop>United States</cop><pmid>37416983</pmid><doi>10.1002/jpen.2547</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7206-735X</orcidid><orcidid>https://orcid.org/0000-0001-8700-0035</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Arachidonic Acid Child Docosahexaenoic Acids Fat Emulsions, Intravenous - chemistry Fatty Acids Fatty Acids, Essential Fish Oils - chemistry Humans Parenteral Nutrition - methods Phospholipids Soybean Oil Swine |
| title | In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled |
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