Dually fibronectin/CD44-mediated nanoparticles targeted disrupt the Golgi apparatus and inhibit the hedgehog signaling in activated hepatic stellate cells to alleviate liver fibrosis

Liver fibrosis is featured by activation of hepatic stellate cells (HSCs) and excessive accumulation of extracellular matrix (ECM). The Golgi apparatus in HSCs plays a vital role in synthesis and secretion of ECM proteins, while its targeted disruption in activated HSCs could be considered as a prom...

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Veröffentlicht in:	Biomaterials 2023-10, Vol.301, p.122232-122232, Article 122232
Hauptverfasser:	Li, Yanping, Zhang, Ting, Zhang, Jinhang, Liu, Qinhui, Jia, Qingyi, Chen, Wenfei, Tang, Qin, Xiong, Yimin, Xia, Yan, Xu, Ying, Mo, Li, Huang, Yuan, He, Jinhan
Format:	Artikel
Sprache:	eng
Schlagworte:	CD44 Fibronectin Golgi apparatus Hedgehog signaling pathway Hepatic stellate cells Liver fibrosis
Online-Zugang:	Volltext
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