Melanoma cells with acquired resistance to vemurafenib have decreased autophagic flux and display enhanced ability to transfer resistance

Over the last years, the incidence of melanoma, the deadliest form of skin cancer, has risen significantly. Nearly half of the melanoma patients exhibit the BRAFV600E mutation. Although the use of BRAF and MEK inhibitors (BRAFi and MEKi) showed an impressive success rate in melanoma patients, durabi...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2023-10, Vol.1869 (7), p.166801-166801, Article 166801
Hauptverfasser:	Pérez, Celia N., Falcón, Cristian R., Mons, Johinna Delgado, Orlandi, Federico Cuello, Sangiacomo, Mercedes, Fernandez-Muñoz, Juan M., Guerrero, Martín, Benito, Paula G., Colombo, María I., Zoppino, Felipe C.M.., Alvarez, Sergio E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy BRAFV600E mutation Melanoma Resistance transfer Vemurafenib
Online-Zugang:	Volltext
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