The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)

•Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The re...

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Veröffentlicht in:Oral oncology 2023-09, Vol.144, p.106483-106483, Article 106483
Hauptverfasser: Norouzi, Ali, Liaghat, Mahsa, Bakhtiyari, Maryam, Noorbakhsh Varnosfaderani, Seyed Mostafa, Zalpoor, Hamidreza, Nabi-Afjadi, Mohsen, Molania, Tahereh
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container_end_page 106483
container_issue
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container_title Oral oncology
container_volume 144
creator Norouzi, Ali
Liaghat, Mahsa
Bakhtiyari, Maryam
Noorbakhsh Varnosfaderani, Seyed Mostafa
Zalpoor, Hamidreza
Nabi-Afjadi, Mohsen
Molania, Tahereh
description •Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The review highlights potential cellular and molecular mechanisms through which SARS-CoV-2 may contribute to these problems in OSCC patients.•Pharmacological targeted therapies based on these mechanisms are suggested as potential treatment options. Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. However, in this study, we encourage more investigations in the future to uncover other cellular and molecular mechanisms of action of SARS-CoV-2 to develop beneficial therapeutic strategies for such patients.
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Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. 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subjects Cancer progression
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Chemo-resistance
COVID-19
Head and Neck Neoplasms
Humans
Mouth Neoplasms
Neoplasm Recurrence, Local - epidemiology
Oral cancer
OSCC
SARS-CoV-2
Squamous Cell Carcinoma of Head and Neck
Tumor recurrence
title The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)
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