The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)
•Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The re...
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Veröffentlicht in: | Oral oncology 2023-09, Vol.144, p.106483-106483, Article 106483 |
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container_title | Oral oncology |
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creator | Norouzi, Ali Liaghat, Mahsa Bakhtiyari, Maryam Noorbakhsh Varnosfaderani, Seyed Mostafa Zalpoor, Hamidreza Nabi-Afjadi, Mohsen Molania, Tahereh |
description | •Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The review highlights potential cellular and molecular mechanisms through which SARS-CoV-2 may contribute to these problems in OSCC patients.•Pharmacological targeted therapies based on these mechanisms are suggested as potential treatment options.
Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. However, in this study, we encourage more investigations in the future to uncover other cellular and molecular mechanisms of action of SARS-CoV-2 to develop beneficial therapeutic strategies for such patients. |
doi_str_mv | 10.1016/j.oraloncology.2023.106483 |
format | Article |
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Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. However, in this study, we encourage more investigations in the future to uncover other cellular and molecular mechanisms of action of SARS-CoV-2 to develop beneficial therapeutic strategies for such patients.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2023.106483</identifier><identifier>PMID: 37421672</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cancer progression ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - metabolism ; Chemo-resistance ; COVID-19 ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms ; Neoplasm Recurrence, Local - epidemiology ; Oral cancer ; OSCC ; SARS-CoV-2 ; Squamous Cell Carcinoma of Head and Neck ; Tumor recurrence</subject><ispartof>Oral oncology, 2023-09, Vol.144, p.106483-106483, Article 106483</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-3876fa71d026597ff35ce397e48901077a923cde17ea5b187f91287648c2efcf3</citedby><cites>FETCH-LOGICAL-c432t-3876fa71d026597ff35ce397e48901077a923cde17ea5b187f91287648c2efcf3</cites><orcidid>0000-0002-8057-2804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.oraloncology.2023.106483$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37421672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norouzi, Ali</creatorcontrib><creatorcontrib>Liaghat, Mahsa</creatorcontrib><creatorcontrib>Bakhtiyari, Maryam</creatorcontrib><creatorcontrib>Noorbakhsh Varnosfaderani, Seyed Mostafa</creatorcontrib><creatorcontrib>Zalpoor, Hamidreza</creatorcontrib><creatorcontrib>Nabi-Afjadi, Mohsen</creatorcontrib><creatorcontrib>Molania, Tahereh</creatorcontrib><title>The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>•Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The review highlights potential cellular and molecular mechanisms through which SARS-CoV-2 may contribute to these problems in OSCC patients.•Pharmacological targeted therapies based on these mechanisms are suggested as potential treatment options.
Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. However, in this study, we encourage more investigations in the future to uncover other cellular and molecular mechanisms of action of SARS-CoV-2 to develop beneficial therapeutic strategies for such patients.</description><subject>Cancer progression</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Chemo-resistance</subject><subject>COVID-19</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Mouth Neoplasms</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Oral cancer</subject><subject>OSCC</subject><subject>SARS-CoV-2</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Tumor recurrence</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxTAQhYMovv-CBFcK9ppH2zTupD5BuAsf2xDTiebSNtekFQR_vClXxaWrJJNzZs58CB1SMqOElqeLmQ-69b3xrX_5mDHCePoo84qvoW1aCZmRQvL1dOdllVVcFFtoJ8YFIaSgBdlEW1zkjJaCbaPPh1fASz9APzjd4uBbwN7iev50e5FRiV2Pl8G_BIjR-f4Em1fofJaeLg66N3CCdd_gYex8wAHMGAKk6tRiyojj26g7P0ZsoG2x0cG43ncaH83v6_p4D21Y3UbY_z530ePV5UN9k93Nr2_r87vM5JwNGa9EabWgDWFlIYW1vDDApYC8koQSIbRk3DRABejiOQGwkrLkySvDwBrLd9HRqm9a5W2EOKjOxSmR7iGFU6ziBSulpDJJz1ZSE3yMAaxaBtfp8KEoURN9tVB_6auJvlrRT-aD7znjcwfNr_UHdxJcrASQtn13EFQ0bgLWuARvUI13_5nzBWtznOE</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Norouzi, Ali</creator><creator>Liaghat, Mahsa</creator><creator>Bakhtiyari, Maryam</creator><creator>Noorbakhsh Varnosfaderani, Seyed Mostafa</creator><creator>Zalpoor, Hamidreza</creator><creator>Nabi-Afjadi, Mohsen</creator><creator>Molania, Tahereh</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8057-2804</orcidid></search><sort><creationdate>202309</creationdate><title>The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)</title><author>Norouzi, Ali ; Liaghat, Mahsa ; Bakhtiyari, Maryam ; Noorbakhsh Varnosfaderani, Seyed Mostafa ; Zalpoor, Hamidreza ; Nabi-Afjadi, Mohsen ; Molania, Tahereh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-3876fa71d026597ff35ce397e48901077a923cde17ea5b187f91287648c2efcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer progression</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Chemo-resistance</topic><topic>COVID-19</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Mouth Neoplasms</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Oral cancer</topic><topic>OSCC</topic><topic>SARS-CoV-2</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Tumor recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norouzi, Ali</creatorcontrib><creatorcontrib>Liaghat, Mahsa</creatorcontrib><creatorcontrib>Bakhtiyari, Maryam</creatorcontrib><creatorcontrib>Noorbakhsh Varnosfaderani, Seyed Mostafa</creatorcontrib><creatorcontrib>Zalpoor, Hamidreza</creatorcontrib><creatorcontrib>Nabi-Afjadi, Mohsen</creatorcontrib><creatorcontrib>Molania, Tahereh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norouzi, Ali</au><au>Liaghat, Mahsa</au><au>Bakhtiyari, Maryam</au><au>Noorbakhsh Varnosfaderani, Seyed Mostafa</au><au>Zalpoor, Hamidreza</au><au>Nabi-Afjadi, Mohsen</au><au>Molania, Tahereh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2023-09</date><risdate>2023</risdate><volume>144</volume><spage>106483</spage><epage>106483</epage><pages>106483-106483</pages><artnum>106483</artnum><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>•Cancer patients, including those with oral squamous cell carcinoma (OSCC), are at a higher risk of severe COVID-19 and cancer progression.•Therapeutic approaches are needed to reduce the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19.•The review highlights potential cellular and molecular mechanisms through which SARS-CoV-2 may contribute to these problems in OSCC patients.•Pharmacological targeted therapies based on these mechanisms are suggested as potential treatment options.
Numerous studies have revealed that cancer patients are more likely to develop severe Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer progression and treatment failure. Among these patients who may be particularly vulnerable to severe COVID-19 and COVID-19-associated cancer progression are those with oral squamous cell carcinoma (OSCC). In this regard, therapeutic approaches must be developed to lower the risk of cancer development, chemo-resistance, tumor recurrence, and death in OSCC patients with COVID-19. It may be helpful to comprehend the cellular and molecular mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to these problems. In this line, in this review, we described the potential cellular and molecular mechanisms that SARS-CoV-2 can exert its role and based on them pharmacological targeted therapies were suggested. However, in this study, we encourage more investigations in the future to uncover other cellular and molecular mechanisms of action of SARS-CoV-2 to develop beneficial therapeutic strategies for such patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37421672</pmid><doi>10.1016/j.oraloncology.2023.106483</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8057-2804</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cancer progression Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Chemo-resistance COVID-19 Head and Neck Neoplasms Humans Mouth Neoplasms Neoplasm Recurrence, Local - epidemiology Oral cancer OSCC SARS-CoV-2 Squamous Cell Carcinoma of Head and Neck Tumor recurrence |
title | The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC) |
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