The expanded ISG12 family in zebrafish: ISG12.1 suppresses virus replication via targeting viral phosphoprotein

In mammals, interferon (IFN)-stimulated genes (ISGs) play important roles in restricting the replication of viruses. However, the functions of many ISGs have not been investigated in fish. In this study, eight isg12 homologs (termed isg12.1-8) were identified in zebrafish and all contain a typical I...

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Veröffentlicht in:	Developmental and comparative immunology 2023-05, Vol.142, p.104672-104672, Article 104672
Hauptverfasser:	Guo, Jiahong, Huang, Wenji, Zhao, Xin, Ji, Ning, Chen, Kangyong, Shi, Yanjie, Feng, Jianhua, Zou, Jun, Wang, Junya
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Animals Antiviral immunity autophagy Carp sprivivirus Danio rerio domain family Fish Diseases hydrophobicity Interferon interferons ISG12 kidneys Mammals Phosphoprotein phosphoproteins Phosphoproteins - genetics Rhabdoviridae Rhabdoviridae Infections spleen SVCV Virus Replication Zebrafish
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