In-cell depolymerization of polysaccharide antigens. Exploring the processing pathways of glycans and why some glycoconjugate vaccines are less effective than expected: A review

Microbial polysaccharides are depolymerized within antigen-presenting cells by reactive nitrogen and reactive oxygen species with no obvious structure alterations. The exact chemical mechanisms of the in-cell processes vary with the structural features of the complex polymers. Free amine-containing...

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