Oral and fecal polio vaccine excretion following bOPV vaccination among Israeli infants
Inactivated polio virus (IPV) vaccinations are a mainstay of immunization schedules in developed countries, while oral polio vaccine (OPV) is administered in developing countries and is the main vaccine in outbreaks. Due to circulating wild poliovirus (WPV1) detection in Israel (2013), oral bivalent...
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| Veröffentlicht in: | Vaccine 2023-06, Vol.41 (28), p.4144-4150 |
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| creator | Chorin, Odelia Markovich, Michal Perry Avramovich, Eva Rahmani, Sarit Sofer, Danit Weil, Merav Shohat, Tamy Chorin, Ehud Tasher, Diana Somekh, Eli |
| description | Inactivated polio virus (IPV) vaccinations are a mainstay of immunization schedules in developed countries, while oral polio vaccine (OPV) is administered in developing countries and is the main vaccine in outbreaks. Due to circulating wild poliovirus (WPV1) detection in Israel (2013), oral bivalent polio vaccination (bOPV) was administered to IPV primed children and incorporated into the vaccination regimen.
We aimed to determine the extent and timeframe of fecal and salivary polio vaccine virus (Sabin strains) shedding following bOPV vaccination among IPV primed children.
Fecal samples were collected from a convenience sample of infants and toddlers attending 11 Israeli daycare centers. Salivary samples were collected from infants and toddlers following bOPV vaccination.
398 fecal samples were collected from 251 children (ages: 6–32 months), 168 received bOPV vaccination 4–55 days prior to sample collection. Fecal excretion continued among 80 %, 50 %, and 20 %, 2, 3, and 7 weeks following vaccination. There were no significant differences in the rate and duration of positive samples among children immunized with 3 or 4 IPV doses. Boys were 2.3-fold more likely to excrete the virus (p = 0.006). Salivary shedding of Sabin strains occurred in 1/47 (2 %) and 1/49 (2 %) samples 4, and 6 days following vaccination respectively.
Fecal detection of Sabin strains among IPV-primed children continues for 7 weeks; additional doses of IPV do not augment intestinal immunity; limited salivary shedding occurs for up to a week. This data can enhance understanding of intestinal immunity achieved by different vaccination schedules and guide recommendations for contact precautions of children following bOPV vaccination. |
| doi_str_mv | 10.1016/j.vaccine.2023.05.036 |
| format | Article |
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We aimed to determine the extent and timeframe of fecal and salivary polio vaccine virus (Sabin strains) shedding following bOPV vaccination among IPV primed children.
Fecal samples were collected from a convenience sample of infants and toddlers attending 11 Israeli daycare centers. Salivary samples were collected from infants and toddlers following bOPV vaccination.
398 fecal samples were collected from 251 children (ages: 6–32 months), 168 received bOPV vaccination 4–55 days prior to sample collection. Fecal excretion continued among 80 %, 50 %, and 20 %, 2, 3, and 7 weeks following vaccination. There were no significant differences in the rate and duration of positive samples among children immunized with 3 or 4 IPV doses. Boys were 2.3-fold more likely to excrete the virus (p = 0.006). Salivary shedding of Sabin strains occurred in 1/47 (2 %) and 1/49 (2 %) samples 4, and 6 days following vaccination respectively.
Fecal detection of Sabin strains among IPV-primed children continues for 7 weeks; additional doses of IPV do not augment intestinal immunity; limited salivary shedding occurs for up to a week. This data can enhance understanding of intestinal immunity achieved by different vaccination schedules and guide recommendations for contact precautions of children following bOPV vaccination.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2023.05.036</identifier><identifier>PMID: 37268556</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Bivalent oral polio vaccine (bOPV) ; Child, Preschool ; Children ; Children & youth ; Day care centers ; Daycare ; Developed countries ; Developing countries ; Enterovirus C ; Epidemics ; Excretion ; Families & family life ; Fecal shedding ; Feces ; Humans ; Immunity ; Immunization ; Immunization Schedule ; Infant ; Infants ; Intestine ; intestines ; Israel ; Laboratories ; LDCs ; Male ; Parents & parenting ; Polio outbreak ; Poliomyelitis ; Poliomyelitis - epidemiology ; Poliovirus ; Poliovirus Vaccine, Inactivated ; Poliovirus Vaccine, Oral ; Salivary excretion ; Schedules ; Shedding ; Strains (organisms) ; Surveillance ; Vaccination ; Vaccines ; Virology ; Viruses</subject><ispartof>Vaccine, 2023-06, Vol.41 (28), p.4144-4150</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Jun 23, 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-e691c76890d3e7ea3ebfb5f22bf0467094624ed56220db343cf0f546763a25a03</citedby><cites>FETCH-LOGICAL-c426t-e691c76890d3e7ea3ebfb5f22bf0467094624ed56220db343cf0f546763a25a03</cites><orcidid>0000-0001-8968-0732 ; 0000-0001-8791-1162 ; 0000-0003-1217-086X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X23005856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37268556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chorin, Odelia</creatorcontrib><creatorcontrib>Markovich, Michal Perry</creatorcontrib><creatorcontrib>Avramovich, Eva</creatorcontrib><creatorcontrib>Rahmani, Sarit</creatorcontrib><creatorcontrib>Sofer, Danit</creatorcontrib><creatorcontrib>Weil, Merav</creatorcontrib><creatorcontrib>Shohat, Tamy</creatorcontrib><creatorcontrib>Chorin, Ehud</creatorcontrib><creatorcontrib>Tasher, Diana</creatorcontrib><creatorcontrib>Somekh, Eli</creatorcontrib><title>Oral and fecal polio vaccine excretion following bOPV vaccination among Israeli infants</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Inactivated polio virus (IPV) vaccinations are a mainstay of immunization schedules in developed countries, while oral polio vaccine (OPV) is administered in developing countries and is the main vaccine in outbreaks. Due to circulating wild poliovirus (WPV1) detection in Israel (2013), oral bivalent polio vaccination (bOPV) was administered to IPV primed children and incorporated into the vaccination regimen.
We aimed to determine the extent and timeframe of fecal and salivary polio vaccine virus (Sabin strains) shedding following bOPV vaccination among IPV primed children.
Fecal samples were collected from a convenience sample of infants and toddlers attending 11 Israeli daycare centers. Salivary samples were collected from infants and toddlers following bOPV vaccination.
398 fecal samples were collected from 251 children (ages: 6–32 months), 168 received bOPV vaccination 4–55 days prior to sample collection. Fecal excretion continued among 80 %, 50 %, and 20 %, 2, 3, and 7 weeks following vaccination. There were no significant differences in the rate and duration of positive samples among children immunized with 3 or 4 IPV doses. Boys were 2.3-fold more likely to excrete the virus (p = 0.006). Salivary shedding of Sabin strains occurred in 1/47 (2 %) and 1/49 (2 %) samples 4, and 6 days following vaccination respectively.
Fecal detection of Sabin strains among IPV-primed children continues for 7 weeks; additional doses of IPV do not augment intestinal immunity; limited salivary shedding occurs for up to a week. This data can enhance understanding of intestinal immunity achieved by different vaccination schedules and guide recommendations for contact precautions of children following bOPV vaccination.</description><subject>Bivalent oral polio vaccine (bOPV)</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Day care centers</subject><subject>Daycare</subject><subject>Developed countries</subject><subject>Developing countries</subject><subject>Enterovirus C</subject><subject>Epidemics</subject><subject>Excretion</subject><subject>Families & family life</subject><subject>Fecal shedding</subject><subject>Feces</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Infant</subject><subject>Infants</subject><subject>Intestine</subject><subject>intestines</subject><subject>Israel</subject><subject>Laboratories</subject><subject>LDCs</subject><subject>Male</subject><subject>Parents & parenting</subject><subject>Polio outbreak</subject><subject>Poliomyelitis</subject><subject>Poliomyelitis - epidemiology</subject><subject>Poliovirus</subject><subject>Poliovirus Vaccine, Inactivated</subject><subject>Poliovirus Vaccine, Oral</subject><subject>Salivary excretion</subject><subject>Schedules</subject><subject>Shedding</subject><subject>Strains (organisms)</subject><subject>Surveillance</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Virology</subject><subject>Viruses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhq0K1C6Fn1AUiQuXhPFnklOFKj4qVVoOtHCzHGeMvMraWztb4N_jZVMOXOA0o5ln3tHMS8gFhYYCVW82zYOx1gdsGDDegGyAqxOyol3LayZp94SsgClRCwpfz8iznDcAIDntT8kZb5nqpFQr8mWdzFSZMFYObcl2cfKxWqQr_GETzj6GysVpit99-FYN6093C2B-t8w2lvJ1TgYnX_ngTJjzc_LUmSnjiyWek9v37z5ffaxv1h-ur97e1FYwNdeoempb1fUwcmzRcBzcIB1jgwOhWuiFYgJHqRiDceCCWwdOlo7ihkkD_Jy8PuruUrzfY5711meL02QCxn3WrOOCiZaC-A-UMd72nPcFffUXuon7FMohB6oFCj2XhZJHyqaYc0Knd8lvTfqpKeiDSXqjl0_qg0kapC4mlbmXi_p-2OL4Z-rRlQJcHgEsn3vwmHS2HoPF0Se0sx6j_8eKX-Gno_I</recordid><startdate>20230623</startdate><enddate>20230623</enddate><creator>Chorin, Odelia</creator><creator>Markovich, Michal Perry</creator><creator>Avramovich, Eva</creator><creator>Rahmani, Sarit</creator><creator>Sofer, Danit</creator><creator>Weil, Merav</creator><creator>Shohat, Tamy</creator><creator>Chorin, Ehud</creator><creator>Tasher, Diana</creator><creator>Somekh, Eli</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-8968-0732</orcidid><orcidid>https://orcid.org/0000-0001-8791-1162</orcidid><orcidid>https://orcid.org/0000-0003-1217-086X</orcidid></search><sort><creationdate>20230623</creationdate><title>Oral and fecal polio vaccine excretion following bOPV vaccination among Israeli infants</title><author>Chorin, Odelia ; Markovich, Michal Perry ; Avramovich, Eva ; Rahmani, Sarit ; Sofer, Danit ; Weil, Merav ; Shohat, Tamy ; Chorin, Ehud ; Tasher, Diana ; Somekh, Eli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-e691c76890d3e7ea3ebfb5f22bf0467094624ed56220db343cf0f546763a25a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bivalent oral polio vaccine (bOPV)</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Day care centers</topic><topic>Daycare</topic><topic>Developed countries</topic><topic>Developing countries</topic><topic>Enterovirus C</topic><topic>Epidemics</topic><topic>Excretion</topic><topic>Families & family life</topic><topic>Fecal shedding</topic><topic>Feces</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Infant</topic><topic>Infants</topic><topic>Intestine</topic><topic>intestines</topic><topic>Israel</topic><topic>Laboratories</topic><topic>LDCs</topic><topic>Male</topic><topic>Parents & parenting</topic><topic>Polio outbreak</topic><topic>Poliomyelitis</topic><topic>Poliomyelitis - epidemiology</topic><topic>Poliovirus</topic><topic>Poliovirus Vaccine, Inactivated</topic><topic>Poliovirus Vaccine, Oral</topic><topic>Salivary excretion</topic><topic>Schedules</topic><topic>Shedding</topic><topic>Strains (organisms)</topic><topic>Surveillance</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chorin, Odelia</creatorcontrib><creatorcontrib>Markovich, Michal Perry</creatorcontrib><creatorcontrib>Avramovich, Eva</creatorcontrib><creatorcontrib>Rahmani, Sarit</creatorcontrib><creatorcontrib>Sofer, Danit</creatorcontrib><creatorcontrib>Weil, Merav</creatorcontrib><creatorcontrib>Shohat, Tamy</creatorcontrib><creatorcontrib>Chorin, Ehud</creatorcontrib><creatorcontrib>Tasher, Diana</creatorcontrib><creatorcontrib>Somekh, Eli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chorin, Odelia</au><au>Markovich, Michal Perry</au><au>Avramovich, Eva</au><au>Rahmani, Sarit</au><au>Sofer, Danit</au><au>Weil, Merav</au><au>Shohat, Tamy</au><au>Chorin, Ehud</au><au>Tasher, Diana</au><au>Somekh, Eli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral and fecal polio vaccine excretion following bOPV vaccination among Israeli infants</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2023-06-23</date><risdate>2023</risdate><volume>41</volume><issue>28</issue><spage>4144</spage><epage>4150</epage><pages>4144-4150</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Inactivated polio virus (IPV) vaccinations are a mainstay of immunization schedules in developed countries, while oral polio vaccine (OPV) is administered in developing countries and is the main vaccine in outbreaks. Due to circulating wild poliovirus (WPV1) detection in Israel (2013), oral bivalent polio vaccination (bOPV) was administered to IPV primed children and incorporated into the vaccination regimen.
We aimed to determine the extent and timeframe of fecal and salivary polio vaccine virus (Sabin strains) shedding following bOPV vaccination among IPV primed children.
Fecal samples were collected from a convenience sample of infants and toddlers attending 11 Israeli daycare centers. Salivary samples were collected from infants and toddlers following bOPV vaccination.
398 fecal samples were collected from 251 children (ages: 6–32 months), 168 received bOPV vaccination 4–55 days prior to sample collection. Fecal excretion continued among 80 %, 50 %, and 20 %, 2, 3, and 7 weeks following vaccination. There were no significant differences in the rate and duration of positive samples among children immunized with 3 or 4 IPV doses. Boys were 2.3-fold more likely to excrete the virus (p = 0.006). Salivary shedding of Sabin strains occurred in 1/47 (2 %) and 1/49 (2 %) samples 4, and 6 days following vaccination respectively.
Fecal detection of Sabin strains among IPV-primed children continues for 7 weeks; additional doses of IPV do not augment intestinal immunity; limited salivary shedding occurs for up to a week. This data can enhance understanding of intestinal immunity achieved by different vaccination schedules and guide recommendations for contact precautions of children following bOPV vaccination.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>37268556</pmid><doi>10.1016/j.vaccine.2023.05.036</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8968-0732</orcidid><orcidid>https://orcid.org/0000-0001-8791-1162</orcidid><orcidid>https://orcid.org/0000-0003-1217-086X</orcidid></addata></record> |
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| ispartof | Vaccine, 2023-06, Vol.41 (28), p.4144-4150 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bivalent oral polio vaccine (bOPV) Child, Preschool Children Children & youth Day care centers Daycare Developed countries Developing countries Enterovirus C Epidemics Excretion Families & family life Fecal shedding Feces Humans Immunity Immunization Immunization Schedule Infant Infants Intestine intestines Israel Laboratories LDCs Male Parents & parenting Polio outbreak Poliomyelitis Poliomyelitis - epidemiology Poliovirus Poliovirus Vaccine, Inactivated Poliovirus Vaccine, Oral Salivary excretion Schedules Shedding Strains (organisms) Surveillance Vaccination Vaccines Virology Viruses |
| title | Oral and fecal polio vaccine excretion following bOPV vaccination among Israeli infants |
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