Wfs1 loss-of-function disrupts the composition of mouse pancreatic endocrine cells from birth and impairs Glut2 localization to cytomembrane in pancreatic β cells

Wfs1 is an endoplasmic reticulum (ER) membrane located protein highly expressed in pancreatic β cells and brain. Wfs1 deficiency causes adult pancreatic β cells dysfunction following β cells apoptosis. Previous studies mainly focus on the Wfs1 function in adult mouse pancreatic β cells. However, whe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-05, Vol.658, p.80-87
Hauptverfasser:	Su, Qiang, Yuan, Fei, Li, Xiaobo, Wang, Xuan, Yang, Kaijiang, Shao, Li, Li, Weida
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals apoptosis brain early development endoplasmic reticulum Endoplasmic Reticulum - metabolism glucose Glut2 homeostasis Insulin Insulin - metabolism Insulin-Secreting Cells - metabolism loss-of-function mutation Mice Pancreatic β cells Wfs1 Wolfram Syndrome - metabolism
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