Neuroprotective effects of fermented tea in MPTP-induced Parkinson's disease mouse model via MAPK signaling-mediated regulation of inflammation and antioxidant activity

[Display omitted] •Semi-fermented tea exerts anti-inflammatory, anti-apoptotic, and anti-oxidant activity.•Semi-fermented tea showed the highest the level of theanine and GABA composition.•Semi-fermented tea alleviated MPTP-induced behavioral impairment and dopaminergic neuronal damage and reduced α...

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Veröffentlicht in:	Food research international 2023-02, Vol.164, p.112133-112133, Article 112133
Hauptverfasser:	Lee, Yu-Rim, Moon, Gyo-Ha, Shim, Doobo, Kim, Jong Cheol, Lee, Kwon-Jai, Chung, Kang-Hyun, An, Jeung Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - therapeutic use 2,2-diphenyl-1-picrylhydrazyl Animals Antioxidant activity Antioxidants - pharmacology Antioxidants - therapeutic use apoptosis ascorbic acid caspase-3 catechin fermentation food research glutathione transferase green tea inducible nitric oxide synthase inflammation Inflammation - drug therapy interleukin-6 Korean Peninsula Mice Mice, Inbred C57BL NADP (coenzyme) Neuroinflammation neurons Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use neurotoxicity Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson’s disease prostaglandin synthase Semi-fermented tea superoxide dismutase Tea theaflavins theanine therapeutics tumor necrosis factor-alpha γ-aminobutyric acid (GABA)
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