Cinnamomum verum extract inhibits NOX2/ROS and PKCδ/JNK/AP-1/NF-κB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes

Cinnamomum verum J. Presl (Cinnamon) is widely used in the food and pharmaceutical industries. C. verum exhibits various biological activities. However, it is unclear whether C. verum can inhibit NOX, a major source of ROS generation, and exert anti-inflammatory and antioxidant effects in PMA-stimul...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2023-04, Vol.112, p.154685-154685, Article 154685
Hauptverfasser:	Kim, Na-Yeon, Kim, Seonhwa, Park, Hyo-Min, Lim, Chae-Min, Kim, Jinju, Park, Jae-Young, Jeon, Kyeong-Bae, Poudel, Amrit, Lee, Hee Pom, Oh, Sei-Ryang, Ahn, Jongmin, Yoon, Do-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammation Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antioxidant antioxidants Antioxidants - pharmacology cinnamic acid Cinnamic acid, Coumarin Cinnamomum verum Cinnamomum zeylanicum Cinnamon coumarin fluorescent antibody technique immunoblotting inflammation interleukin-8 Lipopolysaccharides - pharmacology Monocytes NF-kappa B - metabolism oxidative stress phosphorylation plasma membrane Reactive Oxygen Species - metabolism Signal Transduction Transcription Factor AP-1 - metabolism
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