Effectiveness of the repurposed drug isotretinoin in an experimental murine model of Chagas disease

•Isotretinoin, drug used for severe acne, is trypanocidal in vitro at nanomolar concentrations.•Isotretinoin administration in the chronic phase of T. cruzi infected mice abolished parasitemia.•Isotretinoin improved myocardial compromise in mice. Benznidazole and nifurtimox are the drugs currently u...

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Veröffentlicht in:	Acta tropica 2023-06, Vol.242, p.106920-106920, Article 106920
Hauptverfasser:	Rial, Marcela S, Reigada, Chantal, Prado, Nilda, Bua, Jacqueline, Esteva, Mónica, Pereira, Claudio A, Fichera, Laura E
Format:	Artikel
Sprache:	eng
Schlagworte:	acne amino acids animal models Animals auxins benznidazole blood Chagas disease Chagas Disease - parasitology Disease Models, Animal Drug repurposing electrocardiography family heart rate Isotretinoin Isotretinoin - pharmacology Isotretinoin - therapeutic use mechanism of action Mice Mice, Inbred C57BL Murine model Nicaragua Nitroimidazoles - therapeutic use parasitemia patients Pharmaceutical Preparations polyamines Trypanocidal Agents - therapeutic use Trypanosoma cruzi
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