Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD

High‐fat‐induced endoplasmic reticulum (ER) stress has been the main reason for the occurrence and development of nonalcoholic fatty liver disease (NAFLD). Hydrogen sulfide (H2S) produces a marked effect on regulating lipid metabolism and antioxidation, whose effects on ER stress of NAFLD are still...

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Veröffentlicht in:	The FASEB journal 2023-08, Vol.37 (8), p.e23027-n/a
Hauptverfasser:	Cui, Xiaomeng, Yao, Menglin, Feng, Yanjing, Li, Chengjun, Li, Yarui, Guo, Dan, He, Shuixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat - adverse effects Endoplasmic Reticulum Stress GYY4137 hydrogen sulfide Hydrogen Sulfide - metabolism Lipid Metabolism Liver - metabolism Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - metabolism nonalcoholic fatty liver disease Proprotein Convertase 9 - metabolism SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism
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