Correlation between spherical equivalent and biometry parameters in adult Cynomolgus macaque
To characterize the distribution of refractive and ocular biometry parameters and analyze the effect factors of the refractive status in cynomolgus monkey colonies. A Population-based cross-sectional study was conducted in adult cynomolgus macaque colonies. Animals were anesthetized with Zoletil 50....
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| Veröffentlicht in: | Experimental eye research 2023-08, Vol.233, p.109545-109545, Article 109545 |
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| creator | Chen, Kezhe Wu, Jian Zhao, Feng Wong, Chiwai Liu, Wei Li, Zhidong Chen, Xiaohong Lin, Junxiong Huang, Haishun Zhang, Zhuoyu Zhuo, Xiaohua Xu, Liangzhi Yu, Xianghan Wu, Xiaorong Zhu, Yingting Wang, Ningli Zhuo, Yehong |
| description | To characterize the distribution of refractive and ocular biometry parameters and analyze the effect factors of the refractive status in cynomolgus monkey colonies.
A Population-based cross-sectional study was conducted in adult cynomolgus macaque colonies. Animals were anesthetized with Zoletil 50. Intraocular pressure was measured using the Icare tonometer. Cycloplegic refraction (three drops of 1% tropicamide) and corneal radius of curvature (CRC) were measured using an autorefractor. The spherical equivalent (SE) was calculated. Biometric measurements, including the anterior chamber depth (ACD), lens thickness (LT), and axial length (AL), were obtained by A-scan ultrasonography. The AL-to-CR ratio (AL/CRC) was calculated. Central corneal thickness (CCT) and choroidal thickness (ChT) were measured using the Heidelberg Spectralis HRA OCT. Multiple regression analysis was performed to explore the association between refraction and ocular biometry.
Among 263 cynomolgus monkeys (aged 5–26 years), which consisted of 520 eyes, 29.42% had hyperopia, 27.12% had emmetropia, 33.27% had mild-to-moderate myopia and 10.19% had high myopia. The mean SE was −1.27 ± 3.44 Diopters (D). The mean CRC, CCT, AL, and ChT was 5.70 ± 0.22 mm, 454.30 ± 32.40 μm, 18.76 ± 0.89 mm and 188.96 ± 38.19 μm, respectively. The LT was the thickest in the hyperopic eyes. CRC was the lowest, and CCT was the thickest in high myopic eyes. AL increased, while ChT decreased as SE decreased. For the SE variance, AL alone explained 40.5%; age, AL, and CRC together explained 57.5%.
The refractive characteristics and biometry parameters of cynomolgus monkeys are highly comparable to those of humans. AL, CRC, and ChT showed the similar variation tendency in cynomolguses when compared to humans. Cynomolgus monkeys with naturally-occurring refractive errors may be a good animal model for refractive studies.
•Refractive and biometry range for adult cynomolgus macaque raised in monkey house had been established. Cynomolgus monkeys without any ocular manipulation had high prevalence of myopia. The distribution and the variance tendency of refractive and biometry parameters were comparable to humans'. |
| doi_str_mv | 10.1016/j.exer.2023.109545 |
| format | Article |
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A Population-based cross-sectional study was conducted in adult cynomolgus macaque colonies. Animals were anesthetized with Zoletil 50. Intraocular pressure was measured using the Icare tonometer. Cycloplegic refraction (three drops of 1% tropicamide) and corneal radius of curvature (CRC) were measured using an autorefractor. The spherical equivalent (SE) was calculated. Biometric measurements, including the anterior chamber depth (ACD), lens thickness (LT), and axial length (AL), were obtained by A-scan ultrasonography. The AL-to-CR ratio (AL/CRC) was calculated. Central corneal thickness (CCT) and choroidal thickness (ChT) were measured using the Heidelberg Spectralis HRA OCT. Multiple regression analysis was performed to explore the association between refraction and ocular biometry.
Among 263 cynomolgus monkeys (aged 5–26 years), which consisted of 520 eyes, 29.42% had hyperopia, 27.12% had emmetropia, 33.27% had mild-to-moderate myopia and 10.19% had high myopia. The mean SE was −1.27 ± 3.44 Diopters (D). The mean CRC, CCT, AL, and ChT was 5.70 ± 0.22 mm, 454.30 ± 32.40 μm, 18.76 ± 0.89 mm and 188.96 ± 38.19 μm, respectively. The LT was the thickest in the hyperopic eyes. CRC was the lowest, and CCT was the thickest in high myopic eyes. AL increased, while ChT decreased as SE decreased. For the SE variance, AL alone explained 40.5%; age, AL, and CRC together explained 57.5%.
The refractive characteristics and biometry parameters of cynomolgus monkeys are highly comparable to those of humans. AL, CRC, and ChT showed the similar variation tendency in cynomolguses when compared to humans. Cynomolgus monkeys with naturally-occurring refractive errors may be a good animal model for refractive studies.
•Refractive and biometry range for adult cynomolgus macaque raised in monkey house had been established. Cynomolgus monkeys without any ocular manipulation had high prevalence of myopia. The distribution and the variance tendency of refractive and biometry parameters were comparable to humans'.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1016/j.exer.2023.109545</identifier><identifier>PMID: 37406955</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cynomolgus macaque colony ; Myopia ; Naturally-occurred ametropia</subject><ispartof>Experimental eye research, 2023-08, Vol.233, p.109545-109545, Article 109545</ispartof><rights>2023</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-dc4744ab762edc93f7bfe86c32fd6f2214c8edf119e043f7d28c70c240c72ab13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exer.2023.109545$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37406955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Kezhe</creatorcontrib><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Zhao, Feng</creatorcontrib><creatorcontrib>Wong, Chiwai</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Li, Zhidong</creatorcontrib><creatorcontrib>Chen, Xiaohong</creatorcontrib><creatorcontrib>Lin, Junxiong</creatorcontrib><creatorcontrib>Huang, Haishun</creatorcontrib><creatorcontrib>Zhang, Zhuoyu</creatorcontrib><creatorcontrib>Zhuo, Xiaohua</creatorcontrib><creatorcontrib>Xu, Liangzhi</creatorcontrib><creatorcontrib>Yu, Xianghan</creatorcontrib><creatorcontrib>Wu, Xiaorong</creatorcontrib><creatorcontrib>Zhu, Yingting</creatorcontrib><creatorcontrib>Wang, Ningli</creatorcontrib><creatorcontrib>Zhuo, Yehong</creatorcontrib><title>Correlation between spherical equivalent and biometry parameters in adult Cynomolgus macaque</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>To characterize the distribution of refractive and ocular biometry parameters and analyze the effect factors of the refractive status in cynomolgus monkey colonies.
A Population-based cross-sectional study was conducted in adult cynomolgus macaque colonies. Animals were anesthetized with Zoletil 50. Intraocular pressure was measured using the Icare tonometer. Cycloplegic refraction (three drops of 1% tropicamide) and corneal radius of curvature (CRC) were measured using an autorefractor. The spherical equivalent (SE) was calculated. Biometric measurements, including the anterior chamber depth (ACD), lens thickness (LT), and axial length (AL), were obtained by A-scan ultrasonography. The AL-to-CR ratio (AL/CRC) was calculated. Central corneal thickness (CCT) and choroidal thickness (ChT) were measured using the Heidelberg Spectralis HRA OCT. Multiple regression analysis was performed to explore the association between refraction and ocular biometry.
Among 263 cynomolgus monkeys (aged 5–26 years), which consisted of 520 eyes, 29.42% had hyperopia, 27.12% had emmetropia, 33.27% had mild-to-moderate myopia and 10.19% had high myopia. The mean SE was −1.27 ± 3.44 Diopters (D). The mean CRC, CCT, AL, and ChT was 5.70 ± 0.22 mm, 454.30 ± 32.40 μm, 18.76 ± 0.89 mm and 188.96 ± 38.19 μm, respectively. The LT was the thickest in the hyperopic eyes. CRC was the lowest, and CCT was the thickest in high myopic eyes. AL increased, while ChT decreased as SE decreased. For the SE variance, AL alone explained 40.5%; age, AL, and CRC together explained 57.5%.
The refractive characteristics and biometry parameters of cynomolgus monkeys are highly comparable to those of humans. AL, CRC, and ChT showed the similar variation tendency in cynomolguses when compared to humans. Cynomolgus monkeys with naturally-occurring refractive errors may be a good animal model for refractive studies.
•Refractive and biometry range for adult cynomolgus macaque raised in monkey house had been established. Cynomolgus monkeys without any ocular manipulation had high prevalence of myopia. The distribution and the variance tendency of refractive and biometry parameters were comparable to humans'.</description><subject>Cynomolgus macaque colony</subject><subject>Myopia</subject><subject>Naturally-occurred ametropia</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwAyyQl2xS_MpLYoMqXlIlNrBDshx7Aq6SOLWTQv8eVy0sWc1ofO8dz0HokpI5JTS7Wc3hG_ycEcbjoExFeoSmsckSQkh-jKaEUJGIgqcTdBbCKk65yMUpmvBckKxM0yl6XzjvoVGDdR2uYPgC6HDoP8FbrRoM69FuVAPdgFVncGVdC4Pf4l55FTvwAdsOKzM2A15sO9e65mMMuFVarUc4Rye1agJcHOoMvT3cvy6ekuXL4_PibplontIhMTr-SqgqzxgYXfI6r2ooMs1ZbbKaMSp0AaamtAQi4qthhc6JZoLonKmK8hm63uf23sW1YZCtDRqaRnXgxiBZwXlZFpngUcr2Uu1dCB5q2XvbKr-VlMgdVbmSO6pyR1XuqUbT1SF_rFowf5ZfjFFwuxdAvHJjoz1oC50GYz3oQRpn_8v_AfLsiqo</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Chen, Kezhe</creator><creator>Wu, Jian</creator><creator>Zhao, Feng</creator><creator>Wong, Chiwai</creator><creator>Liu, Wei</creator><creator>Li, Zhidong</creator><creator>Chen, Xiaohong</creator><creator>Lin, Junxiong</creator><creator>Huang, Haishun</creator><creator>Zhang, Zhuoyu</creator><creator>Zhuo, Xiaohua</creator><creator>Xu, Liangzhi</creator><creator>Yu, Xianghan</creator><creator>Wu, Xiaorong</creator><creator>Zhu, Yingting</creator><creator>Wang, Ningli</creator><creator>Zhuo, Yehong</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202308</creationdate><title>Correlation between spherical equivalent and biometry parameters in adult Cynomolgus macaque</title><author>Chen, Kezhe ; Wu, Jian ; Zhao, Feng ; Wong, Chiwai ; Liu, Wei ; Li, Zhidong ; Chen, Xiaohong ; Lin, Junxiong ; Huang, Haishun ; Zhang, Zhuoyu ; Zhuo, Xiaohua ; Xu, Liangzhi ; Yu, Xianghan ; Wu, Xiaorong ; Zhu, Yingting ; Wang, Ningli ; Zhuo, Yehong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-dc4744ab762edc93f7bfe86c32fd6f2214c8edf119e043f7d28c70c240c72ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cynomolgus macaque colony</topic><topic>Myopia</topic><topic>Naturally-occurred ametropia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Kezhe</creatorcontrib><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Zhao, Feng</creatorcontrib><creatorcontrib>Wong, Chiwai</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Li, Zhidong</creatorcontrib><creatorcontrib>Chen, Xiaohong</creatorcontrib><creatorcontrib>Lin, Junxiong</creatorcontrib><creatorcontrib>Huang, Haishun</creatorcontrib><creatorcontrib>Zhang, Zhuoyu</creatorcontrib><creatorcontrib>Zhuo, Xiaohua</creatorcontrib><creatorcontrib>Xu, Liangzhi</creatorcontrib><creatorcontrib>Yu, Xianghan</creatorcontrib><creatorcontrib>Wu, Xiaorong</creatorcontrib><creatorcontrib>Zhu, Yingting</creatorcontrib><creatorcontrib>Wang, Ningli</creatorcontrib><creatorcontrib>Zhuo, Yehong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Kezhe</au><au>Wu, Jian</au><au>Zhao, Feng</au><au>Wong, Chiwai</au><au>Liu, Wei</au><au>Li, Zhidong</au><au>Chen, Xiaohong</au><au>Lin, Junxiong</au><au>Huang, Haishun</au><au>Zhang, Zhuoyu</au><au>Zhuo, Xiaohua</au><au>Xu, Liangzhi</au><au>Yu, Xianghan</au><au>Wu, Xiaorong</au><au>Zhu, Yingting</au><au>Wang, Ningli</au><au>Zhuo, Yehong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between spherical equivalent and biometry parameters in adult Cynomolgus macaque</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>2023-08</date><risdate>2023</risdate><volume>233</volume><spage>109545</spage><epage>109545</epage><pages>109545-109545</pages><artnum>109545</artnum><issn>0014-4835</issn><eissn>1096-0007</eissn><abstract>To characterize the distribution of refractive and ocular biometry parameters and analyze the effect factors of the refractive status in cynomolgus monkey colonies.
A Population-based cross-sectional study was conducted in adult cynomolgus macaque colonies. Animals were anesthetized with Zoletil 50. Intraocular pressure was measured using the Icare tonometer. Cycloplegic refraction (three drops of 1% tropicamide) and corneal radius of curvature (CRC) were measured using an autorefractor. The spherical equivalent (SE) was calculated. Biometric measurements, including the anterior chamber depth (ACD), lens thickness (LT), and axial length (AL), were obtained by A-scan ultrasonography. The AL-to-CR ratio (AL/CRC) was calculated. Central corneal thickness (CCT) and choroidal thickness (ChT) were measured using the Heidelberg Spectralis HRA OCT. Multiple regression analysis was performed to explore the association between refraction and ocular biometry.
Among 263 cynomolgus monkeys (aged 5–26 years), which consisted of 520 eyes, 29.42% had hyperopia, 27.12% had emmetropia, 33.27% had mild-to-moderate myopia and 10.19% had high myopia. The mean SE was −1.27 ± 3.44 Diopters (D). The mean CRC, CCT, AL, and ChT was 5.70 ± 0.22 mm, 454.30 ± 32.40 μm, 18.76 ± 0.89 mm and 188.96 ± 38.19 μm, respectively. The LT was the thickest in the hyperopic eyes. CRC was the lowest, and CCT was the thickest in high myopic eyes. AL increased, while ChT decreased as SE decreased. For the SE variance, AL alone explained 40.5%; age, AL, and CRC together explained 57.5%.
The refractive characteristics and biometry parameters of cynomolgus monkeys are highly comparable to those of humans. AL, CRC, and ChT showed the similar variation tendency in cynomolguses when compared to humans. Cynomolgus monkeys with naturally-occurring refractive errors may be a good animal model for refractive studies.
•Refractive and biometry range for adult cynomolgus macaque raised in monkey house had been established. Cynomolgus monkeys without any ocular manipulation had high prevalence of myopia. The distribution and the variance tendency of refractive and biometry parameters were comparable to humans'.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37406955</pmid><doi>10.1016/j.exer.2023.109545</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cynomolgus macaque colony Myopia Naturally-occurred ametropia |
| title | Correlation between spherical equivalent and biometry parameters in adult Cynomolgus macaque |
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