SARS-CoV-2 main protease mutation analysis via a kinematic method

The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. COVID-19 continues to cause millions of deaths globally in part due to immune-evading mutations. SARS-CoV-2 main protease (Mpro) is an important enzyme for viral replication and poten...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2023-11, Vol.91 (11), p.1496-1509
Hauptverfasser:	Chen, Xiyu, Leyendecker, Sigrid, van den Bedem, Henry
Format:	Artikel
Sprache:	eng
Schlagworte:	Coronaviruses COVID-19 Dynamic structural analysis Flexibility Kinematics Ligands Macromolecules Mutation Pandemics Protease Protein structure Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Viral diseases Viruses
Online-Zugang:	Volltext
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