The Impact of Nanomaterial Morphology on modulation of Carbohydrate Protein interactions
Carbohydrate-protein interactions (CPIs) play a crucial role in the regulation of various physiological and pathological processes within living systems. However, these interactions are typically weak, prompting the development of multivalent probes, including nanoparticles and polymer scaffolds, to...
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| Veröffentlicht in: | ChemMedChem 2023-09, Vol.18 (18), p.e202300262-e202300262 |
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| creator | Bhoge, Preeti Ravindra Chandra, Ankita Kikkeri, Raghavendra V |
| description | Carbohydrate-protein interactions (CPIs) play a crucial role in the regulation of various physiological and pathological processes within living systems. However, these interactions are typically weak, prompting the development of multivalent probes, including nanoparticles and polymer scaffolds, to enhance the avidity of CPIs. Additionally, the morphologies of glyco-nanostructures can significantly impact protein binding, bacterial adhesion, cellular internalization, and immune responses. In this review, we have examined the advancements in glyconanostructures of different shapes that modulate CPIs. We specifically emphasize glyco-nanostructures constructed from small-molecule amphiphilic carbohydrates, block copolymers, metal-based nanoparticles, and carbon-based materials, highlighting their potential applications in glycobiology. |
| doi_str_mv | 10.1002/cmdc.202300262 |
| format | Article |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Avidity Block copolymers Carbohydrates Immune response Internalization Morphology Nanomaterials Nanoparticles Nanostructure Polymers Protein interaction Proteins |
| title | The Impact of Nanomaterial Morphology on modulation of Carbohydrate Protein interactions |
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