Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy
Objectives To evaluate the diagnostic performance of the extraocular muscle volume index at the orbital apex (AMI) and the signal intensity ratio (SIR) of the optic nerve in dysthyroid optic neuropathy (DON). Methods Clinical data and magnetic resonance imaging were collected retrospectively from 63...
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| Veröffentlicht in: | European radiology 2023-12, Vol.33 (12), p.9203-9212 |
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| creator | Song, Cheng Luo, Yaosheng Huang, Weihong Duan, Yongbo Deng, Xuefeng Chen, Haixiong Yu, Genfeng Huang, Kai Xu, Sirong Lin, Xiaoxin Wang, Yi Shen, Jie |
| description | Objectives
To evaluate the diagnostic performance of the extraocular muscle volume index at the orbital apex (AMI) and the signal intensity ratio (SIR) of the optic nerve in dysthyroid optic neuropathy (DON).
Methods
Clinical data and magnetic resonance imaging were collected retrospectively from 63 Graves’ ophthalmopathy patients, including 24 patients with DON and 39 without DON. The volume of these structures was obtained by reconstructing their orbital fat and extraocular muscles. The SIR of the optic nerve and axial length of eyeball were also measured. The posterior 3/5 of the retrobulbar space volume was used as the orbital apex to compare parameters in patients with or without DON. Area under the receiver operating characteristic curve (AUC) analysis was used to select the morphological and inflammatory parameters with the highest diagnostic value. A logistic regression was performed to identify the risk factors of DON.
Results
One hundred twenty-six orbits (35 with DON and 91 without DON) were analyzed. Most of the parameters in DON patients were significantly higher than in non-DON patients. However, the SIR 3 mm behind the eyeball of the optic nerve and AMI had the highest diagnostic value in these parameters and are independent risk factors of DON by stepwise multivariate logistic regression analysis. Combining AMI and SIR had a higher diagnostic value than a single index.
Conclusions
Combining AMI with SIR 3 mm behind the eyeball’s orbital nerve can be a potential parameter for diagnosing DON.
Clinical relevance statement
The present study provided a quantitative index based on morphological and signal changes to assess the DON, allowing clinicians and radiologists to monitor DON patients timely.
Key Points
The extraocular muscle volume index at the orbital apex (AMI) has excellent diagnostic performance for dysthyroid optic neuropathy.
A signal intensity ratio (SIR) of 3 mm behind the eyeball has a higher AUC compared to other slices.
Combining AMI and SIR has a higher diagnostic value than a single index. |
| doi_str_mv | 10.1007/s00330-023-09848-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2833645802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2833645802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-64f679fabf542a534a60fff6291b052d2730fa97ec664ffe8f753dc75fafcaac3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS1ERcstL8ACWWLDJjCxnThmh6ryI1Vi066tiWP3ukriYDtw7yvw1BhSoGLBakYz35wZzSHkeQ2vawD5JgFwDhUwXoHqRFcdHpGzWnBW1dCJxw_yU_I0pTsAULWQT8gplwIaodQZ-X55yBGDWUeMdFqTGS39GsZ1stTPgz1QzDTvLQ2x9xlHikupffN5T8OSvaGzXaPPPr2lSE2Yej_bgS4YcbLZRupCpIPH2zkkn2hwdDimvD_G4IcHAmHBUjwnJw7HZJ_dxx25eX95ffGxuvr84dPFu6vKcNnkqhWulcph7xrBsOECW3DOtUzVPTRsYJKDQyWtaQvqbOdkwwcjG4fOIBq-I6823SWGL6tNWU8-GTuOONuwJs06zlvRdOWvO_LyH_QurHEu1xVKMam6jWIbZWJIKVqnl-gnjEddg_7plN6c0oXVv5zShzL04l567Sc7_Bn5bU0B-Aak0ppvbfy7-z-yPwDdGaKe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2892798802</pqid></control><display><type>article</type><title>Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy</title><source>SpringerLink Journals - AutoHoldings</source><creator>Song, Cheng ; Luo, Yaosheng ; Huang, Weihong ; Duan, Yongbo ; Deng, Xuefeng ; Chen, Haixiong ; Yu, Genfeng ; Huang, Kai ; Xu, Sirong ; Lin, Xiaoxin ; Wang, Yi ; Shen, Jie</creator><creatorcontrib>Song, Cheng ; Luo, Yaosheng ; Huang, Weihong ; Duan, Yongbo ; Deng, Xuefeng ; Chen, Haixiong ; Yu, Genfeng ; Huang, Kai ; Xu, Sirong ; Lin, Xiaoxin ; Wang, Yi ; Shen, Jie</creatorcontrib><description>Objectives
To evaluate the diagnostic performance of the extraocular muscle volume index at the orbital apex (AMI) and the signal intensity ratio (SIR) of the optic nerve in dysthyroid optic neuropathy (DON).
Methods
Clinical data and magnetic resonance imaging were collected retrospectively from 63 Graves’ ophthalmopathy patients, including 24 patients with DON and 39 without DON. The volume of these structures was obtained by reconstructing their orbital fat and extraocular muscles. The SIR of the optic nerve and axial length of eyeball were also measured. The posterior 3/5 of the retrobulbar space volume was used as the orbital apex to compare parameters in patients with or without DON. Area under the receiver operating characteristic curve (AUC) analysis was used to select the morphological and inflammatory parameters with the highest diagnostic value. A logistic regression was performed to identify the risk factors of DON.
Results
One hundred twenty-six orbits (35 with DON and 91 without DON) were analyzed. Most of the parameters in DON patients were significantly higher than in non-DON patients. However, the SIR 3 mm behind the eyeball of the optic nerve and AMI had the highest diagnostic value in these parameters and are independent risk factors of DON by stepwise multivariate logistic regression analysis. Combining AMI and SIR had a higher diagnostic value than a single index.
Conclusions
Combining AMI with SIR 3 mm behind the eyeball’s orbital nerve can be a potential parameter for diagnosing DON.
Clinical relevance statement
The present study provided a quantitative index based on morphological and signal changes to assess the DON, allowing clinicians and radiologists to monitor DON patients timely.
Key Points
The extraocular muscle volume index at the orbital apex (AMI) has excellent diagnostic performance for dysthyroid optic neuropathy.
A signal intensity ratio (SIR) of 3 mm behind the eyeball has a higher AUC compared to other slices.
Combining AMI and SIR has a higher diagnostic value than a single index.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-023-09848-x</identifier><identifier>PMID: 37405499</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apexes ; Diagnostic Radiology ; Diagnostic systems ; Eye ; Imaging ; Inflammation ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Morphology ; Muscles ; Nerves ; Neuritis ; Neuroradiology ; Oculomotor system ; Optic nerve ; Optic neuritis ; Optic neuropathy ; Parameters ; Performance evaluation ; Radiology ; Regression analysis ; Risk factors ; Ultrasound</subject><ispartof>European radiology, 2023-12, Vol.33 (12), p.9203-9212</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to European Society of Radiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-64f679fabf542a534a60fff6291b052d2730fa97ec664ffe8f753dc75fafcaac3</citedby><cites>FETCH-LOGICAL-c375t-64f679fabf542a534a60fff6291b052d2730fa97ec664ffe8f753dc75fafcaac3</cites><orcidid>0000-0001-6952-9541</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-023-09848-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-023-09848-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37405499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Cheng</creatorcontrib><creatorcontrib>Luo, Yaosheng</creatorcontrib><creatorcontrib>Huang, Weihong</creatorcontrib><creatorcontrib>Duan, Yongbo</creatorcontrib><creatorcontrib>Deng, Xuefeng</creatorcontrib><creatorcontrib>Chen, Haixiong</creatorcontrib><creatorcontrib>Yu, Genfeng</creatorcontrib><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Xu, Sirong</creatorcontrib><creatorcontrib>Lin, Xiaoxin</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><title>Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To evaluate the diagnostic performance of the extraocular muscle volume index at the orbital apex (AMI) and the signal intensity ratio (SIR) of the optic nerve in dysthyroid optic neuropathy (DON).
Methods
Clinical data and magnetic resonance imaging were collected retrospectively from 63 Graves’ ophthalmopathy patients, including 24 patients with DON and 39 without DON. The volume of these structures was obtained by reconstructing their orbital fat and extraocular muscles. The SIR of the optic nerve and axial length of eyeball were also measured. The posterior 3/5 of the retrobulbar space volume was used as the orbital apex to compare parameters in patients with or without DON. Area under the receiver operating characteristic curve (AUC) analysis was used to select the morphological and inflammatory parameters with the highest diagnostic value. A logistic regression was performed to identify the risk factors of DON.
Results
One hundred twenty-six orbits (35 with DON and 91 without DON) were analyzed. Most of the parameters in DON patients were significantly higher than in non-DON patients. However, the SIR 3 mm behind the eyeball of the optic nerve and AMI had the highest diagnostic value in these parameters and are independent risk factors of DON by stepwise multivariate logistic regression analysis. Combining AMI and SIR had a higher diagnostic value than a single index.
Conclusions
Combining AMI with SIR 3 mm behind the eyeball’s orbital nerve can be a potential parameter for diagnosing DON.
Clinical relevance statement
The present study provided a quantitative index based on morphological and signal changes to assess the DON, allowing clinicians and radiologists to monitor DON patients timely.
Key Points
The extraocular muscle volume index at the orbital apex (AMI) has excellent diagnostic performance for dysthyroid optic neuropathy.
A signal intensity ratio (SIR) of 3 mm behind the eyeball has a higher AUC compared to other slices.
Combining AMI and SIR has a higher diagnostic value than a single index.</description><subject>Apexes</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Eye</subject><subject>Imaging</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>Muscles</subject><subject>Nerves</subject><subject>Neuritis</subject><subject>Neuroradiology</subject><subject>Oculomotor system</subject><subject>Optic nerve</subject><subject>Optic neuritis</subject><subject>Optic neuropathy</subject><subject>Parameters</subject><subject>Performance evaluation</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Ultrasound</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1TAQhS1ERcstL8ACWWLDJjCxnThmh6ryI1Vi066tiWP3ukriYDtw7yvw1BhSoGLBakYz35wZzSHkeQ2vawD5JgFwDhUwXoHqRFcdHpGzWnBW1dCJxw_yU_I0pTsAULWQT8gplwIaodQZ-X55yBGDWUeMdFqTGS39GsZ1stTPgz1QzDTvLQ2x9xlHikupffN5T8OSvaGzXaPPPr2lSE2Yej_bgS4YcbLZRupCpIPH2zkkn2hwdDimvD_G4IcHAmHBUjwnJw7HZJ_dxx25eX95ffGxuvr84dPFu6vKcNnkqhWulcph7xrBsOECW3DOtUzVPTRsYJKDQyWtaQvqbOdkwwcjG4fOIBq-I6823SWGL6tNWU8-GTuOONuwJs06zlvRdOWvO_LyH_QurHEu1xVKMam6jWIbZWJIKVqnl-gnjEddg_7plN6c0oXVv5zShzL04l567Sc7_Bn5bU0B-Aak0ppvbfy7-z-yPwDdGaKe</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Song, Cheng</creator><creator>Luo, Yaosheng</creator><creator>Huang, Weihong</creator><creator>Duan, Yongbo</creator><creator>Deng, Xuefeng</creator><creator>Chen, Haixiong</creator><creator>Yu, Genfeng</creator><creator>Huang, Kai</creator><creator>Xu, Sirong</creator><creator>Lin, Xiaoxin</creator><creator>Wang, Yi</creator><creator>Shen, Jie</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6952-9541</orcidid></search><sort><creationdate>20231201</creationdate><title>Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy</title><author>Song, Cheng ; Luo, Yaosheng ; Huang, Weihong ; Duan, Yongbo ; Deng, Xuefeng ; Chen, Haixiong ; Yu, Genfeng ; Huang, Kai ; Xu, Sirong ; Lin, Xiaoxin ; Wang, Yi ; Shen, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-64f679fabf542a534a60fff6291b052d2730fa97ec664ffe8f753dc75fafcaac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apexes</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Eye</topic><topic>Imaging</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>Muscles</topic><topic>Nerves</topic><topic>Neuritis</topic><topic>Neuroradiology</topic><topic>Oculomotor system</topic><topic>Optic nerve</topic><topic>Optic neuritis</topic><topic>Optic neuropathy</topic><topic>Parameters</topic><topic>Performance evaluation</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Cheng</creatorcontrib><creatorcontrib>Luo, Yaosheng</creatorcontrib><creatorcontrib>Huang, Weihong</creatorcontrib><creatorcontrib>Duan, Yongbo</creatorcontrib><creatorcontrib>Deng, Xuefeng</creatorcontrib><creatorcontrib>Chen, Haixiong</creatorcontrib><creatorcontrib>Yu, Genfeng</creatorcontrib><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Xu, Sirong</creatorcontrib><creatorcontrib>Lin, Xiaoxin</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni 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Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Cheng</au><au>Luo, Yaosheng</au><au>Huang, Weihong</au><au>Duan, Yongbo</au><au>Deng, Xuefeng</au><au>Chen, Haixiong</au><au>Yu, Genfeng</au><au>Huang, Kai</au><au>Xu, Sirong</au><au>Lin, Xiaoxin</au><au>Wang, Yi</au><au>Shen, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>33</volume><issue>12</issue><spage>9203</spage><epage>9212</epage><pages>9203-9212</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To evaluate the diagnostic performance of the extraocular muscle volume index at the orbital apex (AMI) and the signal intensity ratio (SIR) of the optic nerve in dysthyroid optic neuropathy (DON).
Methods
Clinical data and magnetic resonance imaging were collected retrospectively from 63 Graves’ ophthalmopathy patients, including 24 patients with DON and 39 without DON. The volume of these structures was obtained by reconstructing their orbital fat and extraocular muscles. The SIR of the optic nerve and axial length of eyeball were also measured. The posterior 3/5 of the retrobulbar space volume was used as the orbital apex to compare parameters in patients with or without DON. Area under the receiver operating characteristic curve (AUC) analysis was used to select the morphological and inflammatory parameters with the highest diagnostic value. A logistic regression was performed to identify the risk factors of DON.
Results
One hundred twenty-six orbits (35 with DON and 91 without DON) were analyzed. Most of the parameters in DON patients were significantly higher than in non-DON patients. However, the SIR 3 mm behind the eyeball of the optic nerve and AMI had the highest diagnostic value in these parameters and are independent risk factors of DON by stepwise multivariate logistic regression analysis. Combining AMI and SIR had a higher diagnostic value than a single index.
Conclusions
Combining AMI with SIR 3 mm behind the eyeball’s orbital nerve can be a potential parameter for diagnosing DON.
Clinical relevance statement
The present study provided a quantitative index based on morphological and signal changes to assess the DON, allowing clinicians and radiologists to monitor DON patients timely.
Key Points
The extraocular muscle volume index at the orbital apex (AMI) has excellent diagnostic performance for dysthyroid optic neuropathy.
A signal intensity ratio (SIR) of 3 mm behind the eyeball has a higher AUC compared to other slices.
Combining AMI and SIR has a higher diagnostic value than a single index.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37405499</pmid><doi>10.1007/s00330-023-09848-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6952-9541</orcidid></addata></record> |
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| subjects | Apexes Diagnostic Radiology Diagnostic systems Eye Imaging Inflammation Internal Medicine Interventional Radiology Magnetic Resonance Magnetic resonance imaging Medicine Medicine & Public Health Morphology Muscles Nerves Neuritis Neuroradiology Oculomotor system Optic nerve Optic neuritis Optic neuropathy Parameters Performance evaluation Radiology Regression analysis Risk factors Ultrasound |
| title | Extraocular muscle volume index at the orbital apex with optic neuritis: a combined parameter for diagnosis of dysthyroid optic neuropathy |
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