Memory B cells
Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broa...
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| Veröffentlicht in: | Nature reviews. Immunology 2024-01, Vol.24 (1), p.5-17 |
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| container_title | Nature reviews. Immunology |
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| creator | Inoue, Takeshi Kurosaki, Tomohiro |
| description | Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broadly neutralizing antibodies that bind such variants are key for successful vaccine development. Here, we review the cellular and molecular mechanisms by which memory B cells are generated and how these processes shape the antibody diversity and breadth of memory B cells. Then, we discuss the mechanisms of memory B cell reactivation in the context of established immune memory; the contribution of antibody feedback to this process has now begun to be reappreciated.
Memory B cells are critical for protection against repeated infections, particularly with viral variants, and understanding their function and development is key for successful vaccine development. This Review discusses the cellular and molecular mechanisms of memory B cell generation and reactivation and how these processes shape antibody diversity and breadth. |
| doi_str_mv | 10.1038/s41577-023-00897-3 |
| format | Article |
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Memory B cells are critical for protection against repeated infections, particularly with viral variants, and understanding their function and development is key for successful vaccine development. 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Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Takeshi</au><au>Kurosaki, Tomohiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory B cells</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>5</spage><epage>17</epage><pages>5-17</pages><issn>1474-1733</issn><eissn>1474-1741</eissn><abstract>Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broadly neutralizing antibodies that bind such variants are key for successful vaccine development. 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Memory B cells are critical for protection against repeated infections, particularly with viral variants, and understanding their function and development is key for successful vaccine development. This Review discusses the cellular and molecular mechanisms of memory B cell generation and reactivation and how these processes shape antibody diversity and breadth.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37400644</pmid><doi>10.1038/s41577-023-00897-3</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6352-304X</orcidid><orcidid>https://orcid.org/0000-0002-9972-6105</orcidid></addata></record> |
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| subjects | 631/250/2152/2153/1571 631/250/590 Antibodies Biomedical and Life Sciences Biomedicine Immunological memory Immunology Lymphocytes B Memory cells Molecular modelling Review Article Vaccine development Vaccines |
| title | Memory B cells |
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