Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC), which accounts for 90% of esophageal carcinomas, seriously endangers human health. Worse still, the 5-year overall survival of ESCC is approximately 20%. Elucidation of the potential mechanism and exploration of promising drugs for ESCC are urgently needed....
Gespeichert in:
| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2023-07, Vol.40 (8), p.221-221, Article 221 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 221 |
|---|---|
| container_issue | 8 |
| container_start_page | 221 |
| container_title | Medical oncology (Northwood, London, England) |
| container_volume | 40 |
| creator | Xu, Wei Chen, Yang Zhang, Zhi Jiang, Yuequan Wang, Zhiqiang |
| description | Esophageal squamous cell carcinoma (ESCC), which accounts for 90% of esophageal carcinomas, seriously endangers human health. Worse still, the 5-year overall survival of ESCC is approximately 20%. Elucidation of the potential mechanism and exploration of promising drugs for ESCC are urgently needed. In this study, a high level of exosomal PIK3CB protein was found in the plasma of ESCC patients, which might indicate a poor prognosis. Moreover, a significant Pearson’s correlation was observed at the protein level between exosomal PIK3CB and exosomal PD-L1. Further study revealed that cancer cell-intrinsic and exosome-derived PIK3CB promoted the transcriptional activity of the PD-L1 promoter in ESCC cells. Moreover, treatment with exosomes with lower levels of exosomal PIK3CB decreased the protein level of the mesenchymal marker β-catenin while increasing that of the epithelial marker claudin-1, indicating the potential regulation of epithelial-mesenchymal transition. Consequently, the migratory ability and cancer stemness of ESCC cells and the growth of tumors formed by ESCC cells were decreased with the downregulation of exosomal PIK3CB. Therefore, exosomal PIK3CB plays an oncogenic role by promoting PD-L1 expression and malignant transformation in ESCC. This study may provide new insight into the inherent biological aggressiveness and the poor response to currently available therapies of ESCC. Exosomal PIK3CB may be a promising target for the diagnosis and therapy of ESCC in the future. |
| doi_str_mv | 10.1007/s12032-023-02093-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2833023876</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2833023876</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-7ef7eaa848659b2677113443169ad846bf3d863c603d69d1bf33c8af8dae50ca3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhi1UxPcf6KGy1EsvAduTOM6x3fIlVoJDkbhZs4mzDUrsxZNI8O_xdvmoOHCw7NE8887rGca-SnEshShPSCoBKhMK0hEVZGaL7cmiqDIJ8u7Lf-9dtk90L4SShap22C6Ueaoo9B7rTx8DhQF7fnN5BbNffBXDEEZH_OZ3NpfcPa6iI-qC5-gbnsBu6dGPfIzoqQ1xwHGd7Dx3FFZ_cemSFj1MOISJeO36ntcY686nJodsu8We3NHLfcBuz07_zC6y-fX55eznPKuhLMasdG3pEE1udFEtlC5LKSHPQeoKG5PrRQuN0VBrAY2uGpliqA22pkFXiBrhgP3Y6KbPPEyORjt0tLaC3iVXVhmANDVT6oR-_4Dehyn65G5NqUpIXYhEqQ1Vx0AUXWtXsRswPlkp7HoXdrMLm1Ttv11Yk4q-vUhPi8E1byWvw08AbABKKb908b33J7LPYBaUew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2832901650</pqid></control><display><type>article</type><title>Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Xu, Wei ; Chen, Yang ; Zhang, Zhi ; Jiang, Yuequan ; Wang, Zhiqiang</creator><creatorcontrib>Xu, Wei ; Chen, Yang ; Zhang, Zhi ; Jiang, Yuequan ; Wang, Zhiqiang</creatorcontrib><description>Esophageal squamous cell carcinoma (ESCC), which accounts for 90% of esophageal carcinomas, seriously endangers human health. Worse still, the 5-year overall survival of ESCC is approximately 20%. Elucidation of the potential mechanism and exploration of promising drugs for ESCC are urgently needed. In this study, a high level of exosomal PIK3CB protein was found in the plasma of ESCC patients, which might indicate a poor prognosis. Moreover, a significant Pearson’s correlation was observed at the protein level between exosomal PIK3CB and exosomal PD-L1. Further study revealed that cancer cell-intrinsic and exosome-derived PIK3CB promoted the transcriptional activity of the PD-L1 promoter in ESCC cells. Moreover, treatment with exosomes with lower levels of exosomal PIK3CB decreased the protein level of the mesenchymal marker β-catenin while increasing that of the epithelial marker claudin-1, indicating the potential regulation of epithelial-mesenchymal transition. Consequently, the migratory ability and cancer stemness of ESCC cells and the growth of tumors formed by ESCC cells were decreased with the downregulation of exosomal PIK3CB. Therefore, exosomal PIK3CB plays an oncogenic role by promoting PD-L1 expression and malignant transformation in ESCC. This study may provide new insight into the inherent biological aggressiveness and the poor response to currently available therapies of ESCC. Exosomal PIK3CB may be a promising target for the diagnosis and therapy of ESCC in the future.</description><identifier>ISSN: 1559-131X</identifier><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-023-02093-8</identifier><identifier>PMID: 37402056</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>B7-H1 Antigen - genetics ; B7-H1 Antigen - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Cell Proliferation ; Class I Phosphatidylinositol 3-Kinases - genetics ; Class I Phosphatidylinositol 3-Kinases - metabolism ; Esophageal cancer ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma - genetics ; Esophageal Squamous Cell Carcinoma - pathology ; Gene Expression Regulation, Neoplastic ; Hematology ; Humans ; Internal Medicine ; Medical prognosis ; Medicine ; Medicine & Public Health ; Oncology ; Original Paper ; Pathology ; Prognosis ; Proteins ; Squamous cell carcinoma</subject><ispartof>Medical oncology (Northwood, London, England), 2023-07, Vol.40 (8), p.221-221, Article 221</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-7ef7eaa848659b2677113443169ad846bf3d863c603d69d1bf33c8af8dae50ca3</citedby><cites>FETCH-LOGICAL-c375t-7ef7eaa848659b2677113443169ad846bf3d863c603d69d1bf33c8af8dae50ca3</cites><orcidid>0009-0001-2243-3654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-023-02093-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-023-02093-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37402056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Chen, Yang</creatorcontrib><creatorcontrib>Zhang, Zhi</creatorcontrib><creatorcontrib>Jiang, Yuequan</creatorcontrib><creatorcontrib>Wang, Zhiqiang</creatorcontrib><title>Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Esophageal squamous cell carcinoma (ESCC), which accounts for 90% of esophageal carcinomas, seriously endangers human health. Worse still, the 5-year overall survival of ESCC is approximately 20%. Elucidation of the potential mechanism and exploration of promising drugs for ESCC are urgently needed. In this study, a high level of exosomal PIK3CB protein was found in the plasma of ESCC patients, which might indicate a poor prognosis. Moreover, a significant Pearson’s correlation was observed at the protein level between exosomal PIK3CB and exosomal PD-L1. Further study revealed that cancer cell-intrinsic and exosome-derived PIK3CB promoted the transcriptional activity of the PD-L1 promoter in ESCC cells. Moreover, treatment with exosomes with lower levels of exosomal PIK3CB decreased the protein level of the mesenchymal marker β-catenin while increasing that of the epithelial marker claudin-1, indicating the potential regulation of epithelial-mesenchymal transition. Consequently, the migratory ability and cancer stemness of ESCC cells and the growth of tumors formed by ESCC cells were decreased with the downregulation of exosomal PIK3CB. Therefore, exosomal PIK3CB plays an oncogenic role by promoting PD-L1 expression and malignant transformation in ESCC. This study may provide new insight into the inherent biological aggressiveness and the poor response to currently available therapies of ESCC. Exosomal PIK3CB may be a promising target for the diagnosis and therapy of ESCC in the future.</description><subject>B7-H1 Antigen - genetics</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Class I Phosphatidylinositol 3-Kinases - genetics</subject><subject>Class I Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma - genetics</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Squamous cell carcinoma</subject><issn>1559-131X</issn><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1P3DAQhi1UxPcf6KGy1EsvAduTOM6x3fIlVoJDkbhZs4mzDUrsxZNI8O_xdvmoOHCw7NE8887rGca-SnEshShPSCoBKhMK0hEVZGaL7cmiqDIJ8u7Lf-9dtk90L4SShap22C6Ueaoo9B7rTx8DhQF7fnN5BbNffBXDEEZH_OZ3NpfcPa6iI-qC5-gbnsBu6dGPfIzoqQ1xwHGd7Dx3FFZ_cemSFj1MOISJeO36ntcY686nJodsu8We3NHLfcBuz07_zC6y-fX55eznPKuhLMasdG3pEE1udFEtlC5LKSHPQeoKG5PrRQuN0VBrAY2uGpliqA22pkFXiBrhgP3Y6KbPPEyORjt0tLaC3iVXVhmANDVT6oR-_4Dehyn65G5NqUpIXYhEqQ1Vx0AUXWtXsRswPlkp7HoXdrMLm1Ttv11Yk4q-vUhPi8E1byWvw08AbABKKb908b33J7LPYBaUew</recordid><startdate>20230704</startdate><enddate>20230704</enddate><creator>Xu, Wei</creator><creator>Chen, Yang</creator><creator>Zhang, Zhi</creator><creator>Jiang, Yuequan</creator><creator>Wang, Zhiqiang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0001-2243-3654</orcidid></search><sort><creationdate>20230704</creationdate><title>Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma</title><author>Xu, Wei ; Chen, Yang ; Zhang, Zhi ; Jiang, Yuequan ; Wang, Zhiqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7ef7eaa848659b2677113443169ad846bf3d863c603d69d1bf33c8af8dae50ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>B7-H1 Antigen - genetics</topic><topic>B7-H1 Antigen - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Class I Phosphatidylinositol 3-Kinases - genetics</topic><topic>Class I Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma - genetics</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Chen, Yang</creatorcontrib><creatorcontrib>Zhang, Zhi</creatorcontrib><creatorcontrib>Jiang, Yuequan</creatorcontrib><creatorcontrib>Wang, Zhiqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Wei</au><au>Chen, Yang</au><au>Zhang, Zhi</au><au>Jiang, Yuequan</au><au>Wang, Zhiqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2023-07-04</date><risdate>2023</risdate><volume>40</volume><issue>8</issue><spage>221</spage><epage>221</epage><pages>221-221</pages><artnum>221</artnum><issn>1559-131X</issn><issn>1357-0560</issn><eissn>1559-131X</eissn><abstract>Esophageal squamous cell carcinoma (ESCC), which accounts for 90% of esophageal carcinomas, seriously endangers human health. Worse still, the 5-year overall survival of ESCC is approximately 20%. Elucidation of the potential mechanism and exploration of promising drugs for ESCC are urgently needed. In this study, a high level of exosomal PIK3CB protein was found in the plasma of ESCC patients, which might indicate a poor prognosis. Moreover, a significant Pearson’s correlation was observed at the protein level between exosomal PIK3CB and exosomal PD-L1. Further study revealed that cancer cell-intrinsic and exosome-derived PIK3CB promoted the transcriptional activity of the PD-L1 promoter in ESCC cells. Moreover, treatment with exosomes with lower levels of exosomal PIK3CB decreased the protein level of the mesenchymal marker β-catenin while increasing that of the epithelial marker claudin-1, indicating the potential regulation of epithelial-mesenchymal transition. Consequently, the migratory ability and cancer stemness of ESCC cells and the growth of tumors formed by ESCC cells were decreased with the downregulation of exosomal PIK3CB. Therefore, exosomal PIK3CB plays an oncogenic role by promoting PD-L1 expression and malignant transformation in ESCC. This study may provide new insight into the inherent biological aggressiveness and the poor response to currently available therapies of ESCC. Exosomal PIK3CB may be a promising target for the diagnosis and therapy of ESCC in the future.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37402056</pmid><doi>10.1007/s12032-023-02093-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0009-0001-2243-3654</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1559-131X |
| ispartof | Medical oncology (Northwood, London, England), 2023-07, Vol.40 (8), p.221-221, Article 221 |
| issn | 1559-131X 1357-0560 1559-131X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2833023876 |
| source | MEDLINE; SpringerLink Journals |
| subjects | B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Proliferation Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Esophageal cancer Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - pathology Gene Expression Regulation, Neoplastic Hematology Humans Internal Medicine Medical prognosis Medicine Medicine & Public Health Oncology Original Paper Pathology Prognosis Proteins Squamous cell carcinoma |
| title | Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T07%3A59%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exosomal%20PIK3CB%20promotes%20PD-L1%20expression%20and%20malignant%20transformation%20in%20esophageal%20squamous%20cell%20carcinoma&rft.jtitle=Medical%20oncology%20(Northwood,%20London,%20England)&rft.au=Xu,%20Wei&rft.date=2023-07-04&rft.volume=40&rft.issue=8&rft.spage=221&rft.epage=221&rft.pages=221-221&rft.artnum=221&rft.issn=1559-131X&rft.eissn=1559-131X&rft_id=info:doi/10.1007/s12032-023-02093-8&rft_dat=%3Cproquest_cross%3E2833023876%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2832901650&rft_id=info:pmid/37402056&rfr_iscdi=true |