Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models

Systemic lupus erythematosus (SLE) is a highly female-biased systemic autoimmune disease, but the molecular basis for this female bias remains incompletely elucidated. B and T lymphocytes from patients with SLE and female-biased mouse models of SLE exhibit features of epigenetic dysregulation on the...

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Veröffentlicht in:	Journal of autoimmunity 2023-09, Vol.139, p.103084, Article 103084
Hauptverfasser:	Jiwrajka, Nikhil, Toothacre, Natalie E., Beethem, Zachary T., Sting, Sarah, Forsyth, Katherine S., Dubin, Aimee H., Driscoll, Amanda, Stohl, William, Anguera, Montserrat C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity - genetics B cells B-Lymphocytes - immunology Disease Models, Animal Female Female-biased lupus-like disease Gene Dosage Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lymphocyte Activation Male Mice Mice, Inbred C57BL MRL/lpr mice NZM2328 mice Protein Binding RNA, Long Noncoding - metabolism Sex Factors T cells T-Lymphocytes - immunology X Chromosome Inactivation Xist RNA
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