Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery

Tramadol is metabolized by CYP2D6 to an active metabolite, which in turn acts as an analgesic. This study aimed to investigate the impact of CYP2D6 genotype on the analgesic effect of tramadol in clinical practice. A retrospective cohort study was performed in patients treated with tramadol for post...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2023/07/01, Vol.46(7), pp.907-913
Hauptverfasser:	Kamiya, Takaki, Hira, Daiki, Nakajima, Ryo, Shinoda, Kazuha, Motomochi, Atsuko, Morikochi, Aya, Ikeda, Yoshito, Isono, Tetsuichiro, Akabane, Michiya, Ueshima, Satoshi, Kakumoto, Mikio, Imai, Shinji, Morita, Shin-ya, Terada, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Bone surgery Clinical medicine CYP2D6 CYP2D6 protein Cytochrome P450 Gene polymorphism Orthopedics Pain Patients pharmacodynamics Phenotypes polymorphism precision medicine Regression analysis Surgery Tramadol
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