SIRT1 in the BNST modulates chronic stress-induced anxiety of male mice via FKBP5 and corticotropin-releasing factor signaling

Although clinical reports have highlighted association of the deacetylase sirtuin 1 ( SIRT1 ) gene with anxiety, its exact role in the pathogenesis of anxiety disorders remains unclear. The present study was designed to explore whether and how SIRT1 in the mouse bed nucleus of the stria terminalis (...

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Veröffentlicht in:	Molecular psychiatry 2023-12, Vol.28 (12), p.5101-5117
Hauptverfasser:	Hu, Pu, Wang, Yu, Qi, Xiu-Hong, Shan, Qing-Hong, Huang, Zhao-Huan, Chen, Peng, Ma, Xiao, Yang, Yu-Peng, Swaab, Dick F., Samuels, Benjamin A., Zhang, Zhi, Zhou, Jiang-Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 14/19 38/35 38/77 42/44 42/89 45/15 45/90 631/378 64/110 692/699/476 82/51 82/58 9/74 Animal models Animals Anxiety Anxiety - metabolism Anxiety disorders Anxiety Disorders - metabolism Behavioral Sciences Biological Psychology Calcium imaging Corticotropin-releasing hormone Corticotropin-Releasing Hormone - metabolism Disease Models, Animal Down-regulation Gene silencing Glucocorticoid receptors Hyperactivity Male Mass spectroscopy Medicine Medicine & Public Health Mice Mice, Inbred C57BL Molecular modelling Neurons - metabolism Neurosciences Pharmacotherapy Psychiatry Receptors, Glucocorticoid - metabolism Septal Nuclei - metabolism Signal Transduction - physiology SIRT1 protein Sirtuin 1 - metabolism Stress Stress, Psychological - metabolism Stria terminalis Tacrolimus Binding Proteins - metabolism
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