Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan
Background This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence. Methods This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Ko...
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| Veröffentlicht in: | Annals of surgical oncology 2023-10, Vol.30 (11), p.6855-6864 |
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| container_title | Annals of surgical oncology |
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| creator | Chang, Chi-Son Lai, Yen-Ling Choi, Chel Hun Kim, Tae-Joong Lee, Jeong-Won Kim, Byoung-Gie Cheng, Wen-Fang Chen, Yu-Li Lee, Yoo-Young |
| description | Background
This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence.
Methods
This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Korea and Taiwan. Low-grade advanced-stage endometrial cancer (endometrioid grade 1 or 2) or endometrial cancer with aggressive histology (endometrioid grade 3 or non-endometrioid) at any stage was considered to have a high risk of recurrence. We conducted 1:1 propensity score matching between the MIS and open surgery groups to adjust for the baseline characteristics.
Results
Of the total of 582 patients, 284 patients were included in analysis after matching. Compared with open surgery, MIS did not show a difference in disease-free survival [hazard ratio (HR) 1.09; 95% confidence interval (CI) 0.67–1.77,
P
= 0.717] or overall survival (HR 0.67; 95% CI 0.36–1.24,
P
= 0.198). In the multivariate analysis, non-endometrioid histology, tumor size, tumor cytology, depth of invasion, and lymphovascular space invasion were risk factors for recurrence. There was no association between the surgical approach and either recurrence or mortality in the subgroup analysis according to stage and histology.
Conclusions
MIS did not compromise survival outcomes for patients with endometrial cancer with a high risk of recurrence when compared with open surgery. |
| doi_str_mv | 10.1245/s10434-023-13695-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2832579053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2865938709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-101a182f2de102134f656d4a15f175ad17f49fe14b0f7b8bdf75053b46b64af83</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiNERUvhBTigkbhwCfh_Em7VqtCKVkXd5Ww5ib3rktiL7bTNU_GKeLulSBw4zWjm930e-SuKNxh9wITxjxEjRlmJCC0xFQ0v758VR5jnERM1fp57JOqyIYIfFi9jvEEIVxTxF8UhrWgtKEZHxa-FH7cq2OgdeAOX1tlRDcMM5-5WRXurQbkerrbawXIKax1mMD5A2mhYBa3SqF3aCU9d70edglUDLJTrdIA7mzag4MyuN3Bt448ddq27KQSd95_gBL4Fn42jTTMsOx80XKrUbaxbwzJN_QzWwdc8Vg83rJS9U-5VcWDUEPXrx3pcfP98ulqclRdXX84XJxdlR4lIJUZY4ZoY0muMCKbMCC56pjA3uOKqx5VhjdGYtchUbd32puKI05aJVjBlanpcvN_7boP_OemY5Ghjp4dBOe2nKElNCa-arMnou3_QGz8Fl6_LlOANrSvUZIrsqS74GIM2chvyV4dZYiR3ccp9nDLHKR_ilPdZ9PbRempH3T9J_uSXAboHYl65HM_ft_9j-xu35Kxq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2865938709</pqid></control><display><type>article</type><title>Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan</title><source>SpringerLink Journals</source><creator>Chang, Chi-Son ; Lai, Yen-Ling ; Choi, Chel Hun ; Kim, Tae-Joong ; Lee, Jeong-Won ; Kim, Byoung-Gie ; Cheng, Wen-Fang ; Chen, Yu-Li ; Lee, Yoo-Young</creator><creatorcontrib>Chang, Chi-Son ; Lai, Yen-Ling ; Choi, Chel Hun ; Kim, Tae-Joong ; Lee, Jeong-Won ; Kim, Byoung-Gie ; Cheng, Wen-Fang ; Chen, Yu-Li ; Lee, Yoo-Young</creatorcontrib><description>Background
This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence.
Methods
This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Korea and Taiwan. Low-grade advanced-stage endometrial cancer (endometrioid grade 1 or 2) or endometrial cancer with aggressive histology (endometrioid grade 3 or non-endometrioid) at any stage was considered to have a high risk of recurrence. We conducted 1:1 propensity score matching between the MIS and open surgery groups to adjust for the baseline characteristics.
Results
Of the total of 582 patients, 284 patients were included in analysis after matching. Compared with open surgery, MIS did not show a difference in disease-free survival [hazard ratio (HR) 1.09; 95% confidence interval (CI) 0.67–1.77,
P
= 0.717] or overall survival (HR 0.67; 95% CI 0.36–1.24,
P
= 0.198). In the multivariate analysis, non-endometrioid histology, tumor size, tumor cytology, depth of invasion, and lymphovascular space invasion were risk factors for recurrence. There was no association between the surgical approach and either recurrence or mortality in the subgroup analysis according to stage and histology.
Conclusions
MIS did not compromise survival outcomes for patients with endometrial cancer with a high risk of recurrence when compared with open surgery.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-023-13695-x</identifier><identifier>PMID: 37386310</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cancer ; Cytology ; Endometrial cancer ; Endometrium ; Gynecologic Oncology ; Histology ; Medicine ; Medicine & Public Health ; Minimally invasive surgery ; Multivariate analysis ; Oncology ; Patients ; Risk factors ; Surgery ; Surgical Oncology ; Survival ; Tumors</subject><ispartof>Annals of surgical oncology, 2023-10, Vol.30 (11), p.6855-6864</ispartof><rights>Society of Surgical Oncology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Society of Surgical Oncology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-101a182f2de102134f656d4a15f175ad17f49fe14b0f7b8bdf75053b46b64af83</cites><orcidid>0000-0001-5902-9877 ; 0000-0002-9742-4752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-023-13695-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-023-13695-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37386310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Chi-Son</creatorcontrib><creatorcontrib>Lai, Yen-Ling</creatorcontrib><creatorcontrib>Choi, Chel Hun</creatorcontrib><creatorcontrib>Kim, Tae-Joong</creatorcontrib><creatorcontrib>Lee, Jeong-Won</creatorcontrib><creatorcontrib>Kim, Byoung-Gie</creatorcontrib><creatorcontrib>Cheng, Wen-Fang</creatorcontrib><creatorcontrib>Chen, Yu-Li</creatorcontrib><creatorcontrib>Lee, Yoo-Young</creatorcontrib><title>Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence.
Methods
This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Korea and Taiwan. Low-grade advanced-stage endometrial cancer (endometrioid grade 1 or 2) or endometrial cancer with aggressive histology (endometrioid grade 3 or non-endometrioid) at any stage was considered to have a high risk of recurrence. We conducted 1:1 propensity score matching between the MIS and open surgery groups to adjust for the baseline characteristics.
Results
Of the total of 582 patients, 284 patients were included in analysis after matching. Compared with open surgery, MIS did not show a difference in disease-free survival [hazard ratio (HR) 1.09; 95% confidence interval (CI) 0.67–1.77,
P
= 0.717] or overall survival (HR 0.67; 95% CI 0.36–1.24,
P
= 0.198). In the multivariate analysis, non-endometrioid histology, tumor size, tumor cytology, depth of invasion, and lymphovascular space invasion were risk factors for recurrence. There was no association between the surgical approach and either recurrence or mortality in the subgroup analysis according to stage and histology.
Conclusions
MIS did not compromise survival outcomes for patients with endometrial cancer with a high risk of recurrence when compared with open surgery.</description><subject>Cancer</subject><subject>Cytology</subject><subject>Endometrial cancer</subject><subject>Endometrium</subject><subject>Gynecologic Oncology</subject><subject>Histology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally invasive surgery</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Tumors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc9u1DAQxiNERUvhBTigkbhwCfh_Em7VqtCKVkXd5Ww5ib3rktiL7bTNU_GKeLulSBw4zWjm930e-SuKNxh9wITxjxEjRlmJCC0xFQ0v758VR5jnERM1fp57JOqyIYIfFi9jvEEIVxTxF8UhrWgtKEZHxa-FH7cq2OgdeAOX1tlRDcMM5-5WRXurQbkerrbawXIKax1mMD5A2mhYBa3SqF3aCU9d70edglUDLJTrdIA7mzag4MyuN3Bt448ddq27KQSd95_gBL4Fn42jTTMsOx80XKrUbaxbwzJN_QzWwdc8Vg83rJS9U-5VcWDUEPXrx3pcfP98ulqclRdXX84XJxdlR4lIJUZY4ZoY0muMCKbMCC56pjA3uOKqx5VhjdGYtchUbd32puKI05aJVjBlanpcvN_7boP_OemY5Ghjp4dBOe2nKElNCa-arMnou3_QGz8Fl6_LlOANrSvUZIrsqS74GIM2chvyV4dZYiR3ccp9nDLHKR_ilPdZ9PbRempH3T9J_uSXAboHYl65HM_ft_9j-xu35Kxq</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Chang, Chi-Son</creator><creator>Lai, Yen-Ling</creator><creator>Choi, Chel Hun</creator><creator>Kim, Tae-Joong</creator><creator>Lee, Jeong-Won</creator><creator>Kim, Byoung-Gie</creator><creator>Cheng, Wen-Fang</creator><creator>Chen, Yu-Li</creator><creator>Lee, Yoo-Young</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5902-9877</orcidid><orcidid>https://orcid.org/0000-0002-9742-4752</orcidid></search><sort><creationdate>20231001</creationdate><title>Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan</title><author>Chang, Chi-Son ; Lai, Yen-Ling ; Choi, Chel Hun ; Kim, Tae-Joong ; Lee, Jeong-Won ; Kim, Byoung-Gie ; Cheng, Wen-Fang ; Chen, Yu-Li ; Lee, Yoo-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-101a182f2de102134f656d4a15f175ad17f49fe14b0f7b8bdf75053b46b64af83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>Cytology</topic><topic>Endometrial cancer</topic><topic>Endometrium</topic><topic>Gynecologic Oncology</topic><topic>Histology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally invasive surgery</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Chi-Son</creatorcontrib><creatorcontrib>Lai, Yen-Ling</creatorcontrib><creatorcontrib>Choi, Chel Hun</creatorcontrib><creatorcontrib>Kim, Tae-Joong</creatorcontrib><creatorcontrib>Lee, Jeong-Won</creatorcontrib><creatorcontrib>Kim, Byoung-Gie</creatorcontrib><creatorcontrib>Cheng, Wen-Fang</creatorcontrib><creatorcontrib>Chen, Yu-Li</creatorcontrib><creatorcontrib>Lee, Yoo-Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Chi-Son</au><au>Lai, Yen-Ling</au><au>Choi, Chel Hun</au><au>Kim, Tae-Joong</au><au>Lee, Jeong-Won</au><au>Kim, Byoung-Gie</au><au>Cheng, Wen-Fang</au><au>Chen, Yu-Li</au><au>Lee, Yoo-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>30</volume><issue>11</issue><spage>6855</spage><epage>6864</epage><pages>6855-6864</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence.
Methods
This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Korea and Taiwan. Low-grade advanced-stage endometrial cancer (endometrioid grade 1 or 2) or endometrial cancer with aggressive histology (endometrioid grade 3 or non-endometrioid) at any stage was considered to have a high risk of recurrence. We conducted 1:1 propensity score matching between the MIS and open surgery groups to adjust for the baseline characteristics.
Results
Of the total of 582 patients, 284 patients were included in analysis after matching. Compared with open surgery, MIS did not show a difference in disease-free survival [hazard ratio (HR) 1.09; 95% confidence interval (CI) 0.67–1.77,
P
= 0.717] or overall survival (HR 0.67; 95% CI 0.36–1.24,
P
= 0.198). In the multivariate analysis, non-endometrioid histology, tumor size, tumor cytology, depth of invasion, and lymphovascular space invasion were risk factors for recurrence. There was no association between the surgical approach and either recurrence or mortality in the subgroup analysis according to stage and histology.
Conclusions
MIS did not compromise survival outcomes for patients with endometrial cancer with a high risk of recurrence when compared with open surgery.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37386310</pmid><doi>10.1245/s10434-023-13695-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5902-9877</orcidid><orcidid>https://orcid.org/0000-0002-9742-4752</orcidid></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2023-10, Vol.30 (11), p.6855-6864 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2832579053 |
| source | SpringerLink Journals |
| subjects | Cancer Cytology Endometrial cancer Endometrium Gynecologic Oncology Histology Medicine Medicine & Public Health Minimally invasive surgery Multivariate analysis Oncology Patients Risk factors Surgery Surgical Oncology Survival Tumors |
| title | Comparison of Minimally Invasive and Open Surgery for the Treatment of Endometrial Cancer with a High Risk of Recurrence: A Propensity Score Matching Study in Korea and Taiwan |
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