Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease

Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there ar...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Drug development research 2023-09, Vol.84 (6), p.1096-1113
Hauptverfasser: Wang, Meiwei, Cao, Linghui
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1113
container_issue 6
container_start_page 1096
container_title Drug development research
container_volume 84
creator Wang, Meiwei
Cao, Linghui
description Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial-mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.
doi_str_mv 10.1002/ddr.22089
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2832577596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2863676132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c313t-17c21c2c55c49aa2d0040bdb88176163798469d1645133b9c209fec42163ff083</originalsourceid><addsrcrecordid>eNpdkEtLAzEQgIMotlYP_gEJeNHD1jx28zhK8QUFL3p1ySZZm7K7qUn20H9vaqsHYWBg5mMeHwCXGM0xQuTOmDAnBAl5BKYYSVEQIuUxmCLCSVFSiSfgLMY1QhiXQpyCCeVUMF6xKfh43prgu21UTWdhUsPghghVDrjxyQ7JqQ6mlQ1qY8fkNDRh_IStD7siXI29GmDrmuCji4WK0WunkjXQuGhVtOfgpFVdtBeHPAPvjw9vi-di-fr0srhfFppimgrMNcGa6KrSpVSKGIRK1JhGCMwZZpRLUTJpMCsrTGkjNUGytbokude2SNAZuNnP3QT_NdqY6t5FbbtODdaPsSaCkorzSrKMXv9D134MQ74uU4yyvJCSTN3uKZ1fi8G29Sa4XoVtjVG9k15n6fWP9MxeHSaOTW_NH_lrmX4D2EN79A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2863676132</pqid></control><display><type>article</type><title>Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease</title><source>Access via Wiley Online Library</source><creator>Wang, Meiwei ; Cao, Linghui</creator><creatorcontrib>Wang, Meiwei ; Cao, Linghui</creatorcontrib><description>Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial-mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.22089</identifier><identifier>PMID: 37386756</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Extracellular matrix ; Fibrosis ; Morbidity ; Natural products ; Oxidative stress ; Pathogenesis ; Regeneration (physiology) ; Tannins ; Tissue engineering</subject><ispartof>Drug development research, 2023-09, Vol.84 (6), p.1096-1113</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-17c21c2c55c49aa2d0040bdb88176163798469d1645133b9c209fec42163ff083</citedby><cites>FETCH-LOGICAL-c313t-17c21c2c55c49aa2d0040bdb88176163798469d1645133b9c209fec42163ff083</cites><orcidid>0000-0002-9203-2477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37386756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Meiwei</creatorcontrib><creatorcontrib>Cao, Linghui</creatorcontrib><title>Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease</title><title>Drug development research</title><addtitle>Drug Dev Res</addtitle><description>Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial-mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.</description><subject>Extracellular matrix</subject><subject>Fibrosis</subject><subject>Morbidity</subject><subject>Natural products</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Regeneration (physiology)</subject><subject>Tannins</subject><subject>Tissue engineering</subject><issn>0272-4391</issn><issn>1098-2299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLAzEQgIMotlYP_gEJeNHD1jx28zhK8QUFL3p1ySZZm7K7qUn20H9vaqsHYWBg5mMeHwCXGM0xQuTOmDAnBAl5BKYYSVEQIuUxmCLCSVFSiSfgLMY1QhiXQpyCCeVUMF6xKfh43prgu21UTWdhUsPghghVDrjxyQ7JqQ6mlQ1qY8fkNDRh_IStD7siXI29GmDrmuCji4WK0WunkjXQuGhVtOfgpFVdtBeHPAPvjw9vi-di-fr0srhfFppimgrMNcGa6KrSpVSKGIRK1JhGCMwZZpRLUTJpMCsrTGkjNUGytbokude2SNAZuNnP3QT_NdqY6t5FbbtODdaPsSaCkorzSrKMXv9D134MQ74uU4yyvJCSTN3uKZ1fi8G29Sa4XoVtjVG9k15n6fWP9MxeHSaOTW_NH_lrmX4D2EN79A</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Wang, Meiwei</creator><creator>Cao, Linghui</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9203-2477</orcidid></search><sort><creationdate>20230901</creationdate><title>Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease</title><author>Wang, Meiwei ; Cao, Linghui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-17c21c2c55c49aa2d0040bdb88176163798469d1645133b9c209fec42163ff083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Extracellular matrix</topic><topic>Fibrosis</topic><topic>Morbidity</topic><topic>Natural products</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Regeneration (physiology)</topic><topic>Tannins</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Meiwei</creatorcontrib><creatorcontrib>Cao, Linghui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Meiwei</au><au>Cao, Linghui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease</atitle><jtitle>Drug development research</jtitle><addtitle>Drug Dev Res</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>84</volume><issue>6</issue><spage>1096</spage><epage>1113</epage><pages>1096-1113</pages><issn>0272-4391</issn><eissn>1098-2299</eissn><abstract>Fibrosis is a pathological change with abnormal tissue regeneration due to a response to persistent injury, which is extensively related to organ damage and failure, leading to high morbidity and mortality worldwide. Although the pathogenesis of fibrosis has been comprehensively elucidated, there are few effective therapies for treating fibrotic diseases. Natural products are increasingly regarded as an effective strategy for fibrosis with numerous favorable functions. Hydrolysable tannins (HT) are a type of natural products that have the potential to treat the fibrotic disease. In this review, we describe some biological activities and the therapeutic prospects of HT in organ fibrosis. Furthermore, the underlying mechanisms of inhibition of HT on fibrotic organs in relation to inflammation, oxidative stress, epithelial-mesenchymal transition, fibroblast activation and proliferation, and extracellular matrix accumulation are discussed. Understanding the mechanism of HT against fibrotic diseases will provide a new strategy for the prevention and attenuation of fibrosis progression.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37386756</pmid><doi>10.1002/ddr.22089</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-9203-2477</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0272-4391
ispartof Drug development research, 2023-09, Vol.84 (6), p.1096-1113
issn 0272-4391
1098-2299
language eng
recordid cdi_proquest_miscellaneous_2832577596
source Access via Wiley Online Library
subjects Extracellular matrix
Fibrosis
Morbidity
Natural products
Oxidative stress
Pathogenesis
Regeneration (physiology)
Tannins
Tissue engineering
title Hydrolysable tannins as a potential therapeutic drug for the human fibrosis-associated disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T20%3A54%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hydrolysable%20tannins%20as%20a%20potential%20therapeutic%20drug%20for%20the%20human%20fibrosis-associated%20disease&rft.jtitle=Drug%20development%20research&rft.au=Wang,%20Meiwei&rft.date=2023-09-01&rft.volume=84&rft.issue=6&rft.spage=1096&rft.epage=1113&rft.pages=1096-1113&rft.issn=0272-4391&rft.eissn=1098-2299&rft_id=info:doi/10.1002/ddr.22089&rft_dat=%3Cproquest_cross%3E2863676132%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2863676132&rft_id=info:pmid/37386756&rfr_iscdi=true