Antineoplastic activity of plant-derived compounds mediated through inhibition of histone deacetylase: a review

In the combat of treating cancer recent therapeutic approaches are focused towards enzymatic targets as they occupy a pivotal participation in the cascade of oncogenesis and malignancy. There are several enzymes that modulate the epigenetic pathways and chromatin structure related to cancer mutation...

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Veröffentlicht in:	Amino acids 2023-12, Vol.55 (12), p.1803-1817
Hauptverfasser:	Rajaselvi, N. Divya, Jida, M. D., Ajeeshkumar, K. K., Nair, Suresh N., John, Preethy, Aziz, Zarina, Nisha, A. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Analytical Chemistry Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Bioactive compounds Biochemical Engineering Biochemistry Biocompatibility Biological activity Biomedical and Life Sciences Cancer Cell cycle Chromatin Cyclin-dependent kinase inhibitor p21 Cytotoxicity Enzymes Epigenetics Euchromatin Flavonoids Gene expression Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Histone Deacetylases - therapeutic use Histones Histones - metabolism Inhibitors Life Sciences Malignancy Neoplasms - drug therapy Neoplasms - genetics Neurobiology Phosphorylation Phytochemicals Plants Polyphenols Proteomics Review Article SUMO protein Transcription factors Tumor cell lines Tumorigenesis
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