Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin
Background The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues. Aims This study aim...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2024-01, Vol.23 (1), p.215-226 |
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| creator | Park, Hyun‐A Seo, Hoonhee Kim, Sukyung Haq, Asad Ul Bae, Sung Hae Lee, Hyun‐Ji Ju, Se Hee Tajdozian, Hanieh Rahim, Md Abdur Ghorbanian, Fatemeh Barman, Indrajeet Yoon, Youjin Jo, Sujin Lee, Youngkyoung Cho, Gyutae Jo, Hyein Kim, Mijung Lee, Saebim Song, Ho‐Yeon |
| description | Background
The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues.
Aims
This study aimed to evaluate the potential role of Pediococcus acidilactici PMC48 as a probiotic strain in medicines and cosmetics for skin treatment.
Materials and Methods
Meanwhile, our research team has reported that P. acidilactici PMC48 strain isolated from sesame leaf kimchi can directly decompose the already synthesized melanin. It can also inhibit melanin biosynthesis. In the present study, we investigated the skin‐whitening effect of this strain by arranging an 8‐week clinical trial with 22 participants. PMC48 was applied to each participant's artificially UV‐induced tanned skin in the clinical trial. Its whitening effect was investigated based on visual evaluation, skin brightness, and melanin index.
Results
PMC48 showed a significant effect on the artificially induced pigmented skin. The color intensity of the tanned skin was decreased by 47.647%, and skin brightness was increased by 8.098% after the treatment period. PMC48 also significantly decreased the melanin index by 11.818%, indicating its tyrosinase inhibition capacity. Also, PMC48 improved skin moisture content level by 20.943%. Additionally, 16S rRNA‐based amplicon sequencing analysis showed a distinct increase in Lactobacillaceae in the skin by up to 11.2% at the family level without affecting other skin microbiota. Furthermore, it showed no toxicity in in vitro or in vivo analyses.
Discussion
These results indicate that P. acidilactici PMC48 is a promising probiotic strain that can be used to develop medicines and cosmetic products to solve skin‐related problems.
Conclusions
These results demonstrate that P. acidilactici PMC48 can be a potential probiotic for the cosmetic industry against different skin disorders. |
| doi_str_mv | 10.1111/jocd.15891 |
| format | Article |
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The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues.
Aims
This study aimed to evaluate the potential role of Pediococcus acidilactici PMC48 as a probiotic strain in medicines and cosmetics for skin treatment.
Materials and Methods
Meanwhile, our research team has reported that P. acidilactici PMC48 strain isolated from sesame leaf kimchi can directly decompose the already synthesized melanin. It can also inhibit melanin biosynthesis. In the present study, we investigated the skin‐whitening effect of this strain by arranging an 8‐week clinical trial with 22 participants. PMC48 was applied to each participant's artificially UV‐induced tanned skin in the clinical trial. Its whitening effect was investigated based on visual evaluation, skin brightness, and melanin index.
Results
PMC48 showed a significant effect on the artificially induced pigmented skin. The color intensity of the tanned skin was decreased by 47.647%, and skin brightness was increased by 8.098% after the treatment period. PMC48 also significantly decreased the melanin index by 11.818%, indicating its tyrosinase inhibition capacity. Also, PMC48 improved skin moisture content level by 20.943%. Additionally, 16S rRNA‐based amplicon sequencing analysis showed a distinct increase in Lactobacillaceae in the skin by up to 11.2% at the family level without affecting other skin microbiota. Furthermore, it showed no toxicity in in vitro or in vivo analyses.
Discussion
These results indicate that P. acidilactici PMC48 is a promising probiotic strain that can be used to develop medicines and cosmetic products to solve skin‐related problems.
Conclusions
These results demonstrate that P. acidilactici PMC48 can be a potential probiotic for the cosmetic industry against different skin disorders.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.15891</identifier><identifier>PMID: 37381171</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Acids ; Clinical trials ; Cytotoxicity ; Dermatitis ; hyperpigmentation ; melanin ; microbiome ; Moisture content ; Oxidation ; Pediococcus acidilactici ; PMC48 ; Probiotics ; Skin ; Temperature</subject><ispartof>Journal of cosmetic dermatology, 2024-01, Vol.23 (1), p.215-226</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4471-74ee4c752125882fe53dd84fa2e69208aeb2ddd406615e81c8a1572495b4a6043</citedby><cites>FETCH-LOGICAL-c4471-74ee4c752125882fe53dd84fa2e69208aeb2ddd406615e81c8a1572495b4a6043</cites><orcidid>0000-0002-5932-6633 ; 0000-0001-5426-4050 ; 0000-0002-3602-7980 ; 0000-0002-9148-4535 ; 0000-0002-7299-1240 ; 0000-0003-4429-1383 ; 0000-0002-1260-7702 ; 0000-0002-7963-9776</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.15891$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.15891$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37381171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hyun‐A</creatorcontrib><creatorcontrib>Seo, Hoonhee</creatorcontrib><creatorcontrib>Kim, Sukyung</creatorcontrib><creatorcontrib>Haq, Asad Ul</creatorcontrib><creatorcontrib>Bae, Sung Hae</creatorcontrib><creatorcontrib>Lee, Hyun‐Ji</creatorcontrib><creatorcontrib>Ju, Se Hee</creatorcontrib><creatorcontrib>Tajdozian, Hanieh</creatorcontrib><creatorcontrib>Rahim, Md Abdur</creatorcontrib><creatorcontrib>Ghorbanian, Fatemeh</creatorcontrib><creatorcontrib>Barman, Indrajeet</creatorcontrib><creatorcontrib>Yoon, Youjin</creatorcontrib><creatorcontrib>Jo, Sujin</creatorcontrib><creatorcontrib>Lee, Youngkyoung</creatorcontrib><creatorcontrib>Cho, Gyutae</creatorcontrib><creatorcontrib>Jo, Hyein</creatorcontrib><creatorcontrib>Kim, Mijung</creatorcontrib><creatorcontrib>Lee, Saebim</creatorcontrib><creatorcontrib>Song, Ho‐Yeon</creatorcontrib><title>Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues.
Aims
This study aimed to evaluate the potential role of Pediococcus acidilactici PMC48 as a probiotic strain in medicines and cosmetics for skin treatment.
Materials and Methods
Meanwhile, our research team has reported that P. acidilactici PMC48 strain isolated from sesame leaf kimchi can directly decompose the already synthesized melanin. It can also inhibit melanin biosynthesis. In the present study, we investigated the skin‐whitening effect of this strain by arranging an 8‐week clinical trial with 22 participants. PMC48 was applied to each participant's artificially UV‐induced tanned skin in the clinical trial. Its whitening effect was investigated based on visual evaluation, skin brightness, and melanin index.
Results
PMC48 showed a significant effect on the artificially induced pigmented skin. The color intensity of the tanned skin was decreased by 47.647%, and skin brightness was increased by 8.098% after the treatment period. PMC48 also significantly decreased the melanin index by 11.818%, indicating its tyrosinase inhibition capacity. Also, PMC48 improved skin moisture content level by 20.943%. Additionally, 16S rRNA‐based amplicon sequencing analysis showed a distinct increase in Lactobacillaceae in the skin by up to 11.2% at the family level without affecting other skin microbiota. Furthermore, it showed no toxicity in in vitro or in vivo analyses.
Discussion
These results indicate that P. acidilactici PMC48 is a promising probiotic strain that can be used to develop medicines and cosmetic products to solve skin‐related problems.
Conclusions
These results demonstrate that P. acidilactici PMC48 can be a potential probiotic for the cosmetic industry against different skin disorders.</description><subject>Acids</subject><subject>Clinical trials</subject><subject>Cytotoxicity</subject><subject>Dermatitis</subject><subject>hyperpigmentation</subject><subject>melanin</subject><subject>microbiome</subject><subject>Moisture content</subject><subject>Oxidation</subject><subject>Pediococcus acidilactici</subject><subject>PMC48</subject><subject>Probiotics</subject><subject>Skin</subject><subject>Temperature</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kD1PwzAQQC0EoqWw8ANQJBaE1OLzR-KMKHwUBIIBZsu1L-CSxiVOhPrvCRQ6MHDL3fD0dHqEHAKdQD9n82DdBKTKYYsMQWR8zCCV25ub0wHZi3FOKWQ5yF0y4BlXABkMybSofO2tqRIsS7RtEsrkEZ0PNljbxcRY73xlbOutTx7vC6GSUCevqyU2S_-ywLpFl8Q3X--TndJUEQ9-9og8X10-FdPx3cP1TXF-N7ZCZDDOBKKwmWTApFKsRMmdU6I0DNOcUWVwxpxzgqYpSFRglQGZMZHLmTApFXxETtbeZRPeO4ytXvhosapMjaGLmikOLO-H9ujxH3Qeuqbuv9Oc5jQFLnp6RE7XlG1CjA2Wetn4hWlWGqj-6qu_-urvvj189KPsZgt0G_Q3aA_AGvjwFa7-Uenbh-JiLf0EcUiC2w</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Park, Hyun‐A</creator><creator>Seo, Hoonhee</creator><creator>Kim, Sukyung</creator><creator>Haq, Asad Ul</creator><creator>Bae, Sung Hae</creator><creator>Lee, Hyun‐Ji</creator><creator>Ju, Se Hee</creator><creator>Tajdozian, Hanieh</creator><creator>Rahim, Md Abdur</creator><creator>Ghorbanian, Fatemeh</creator><creator>Barman, Indrajeet</creator><creator>Yoon, Youjin</creator><creator>Jo, Sujin</creator><creator>Lee, Youngkyoung</creator><creator>Cho, Gyutae</creator><creator>Jo, Hyein</creator><creator>Kim, Mijung</creator><creator>Lee, Saebim</creator><creator>Song, Ho‐Yeon</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5932-6633</orcidid><orcidid>https://orcid.org/0000-0001-5426-4050</orcidid><orcidid>https://orcid.org/0000-0002-3602-7980</orcidid><orcidid>https://orcid.org/0000-0002-9148-4535</orcidid><orcidid>https://orcid.org/0000-0002-7299-1240</orcidid><orcidid>https://orcid.org/0000-0003-4429-1383</orcidid><orcidid>https://orcid.org/0000-0002-1260-7702</orcidid><orcidid>https://orcid.org/0000-0002-7963-9776</orcidid></search><sort><creationdate>202401</creationdate><title>Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin</title><author>Park, Hyun‐A ; Seo, Hoonhee ; Kim, Sukyung ; Haq, Asad Ul ; Bae, Sung Hae ; Lee, Hyun‐Ji ; Ju, Se Hee ; Tajdozian, Hanieh ; Rahim, Md Abdur ; Ghorbanian, Fatemeh ; Barman, Indrajeet ; Yoon, Youjin ; Jo, Sujin ; Lee, Youngkyoung ; Cho, Gyutae ; Jo, Hyein ; Kim, Mijung ; Lee, Saebim ; Song, Ho‐Yeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4471-74ee4c752125882fe53dd84fa2e69208aeb2ddd406615e81c8a1572495b4a6043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>Clinical trials</topic><topic>Cytotoxicity</topic><topic>Dermatitis</topic><topic>hyperpigmentation</topic><topic>melanin</topic><topic>microbiome</topic><topic>Moisture content</topic><topic>Oxidation</topic><topic>Pediococcus acidilactici</topic><topic>PMC48</topic><topic>Probiotics</topic><topic>Skin</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hyun‐A</creatorcontrib><creatorcontrib>Seo, Hoonhee</creatorcontrib><creatorcontrib>Kim, Sukyung</creatorcontrib><creatorcontrib>Haq, Asad Ul</creatorcontrib><creatorcontrib>Bae, Sung Hae</creatorcontrib><creatorcontrib>Lee, Hyun‐Ji</creatorcontrib><creatorcontrib>Ju, Se Hee</creatorcontrib><creatorcontrib>Tajdozian, Hanieh</creatorcontrib><creatorcontrib>Rahim, Md Abdur</creatorcontrib><creatorcontrib>Ghorbanian, Fatemeh</creatorcontrib><creatorcontrib>Barman, Indrajeet</creatorcontrib><creatorcontrib>Yoon, Youjin</creatorcontrib><creatorcontrib>Jo, Sujin</creatorcontrib><creatorcontrib>Lee, Youngkyoung</creatorcontrib><creatorcontrib>Cho, Gyutae</creatorcontrib><creatorcontrib>Jo, Hyein</creatorcontrib><creatorcontrib>Kim, Mijung</creatorcontrib><creatorcontrib>Lee, Saebim</creatorcontrib><creatorcontrib>Song, Ho‐Yeon</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hyun‐A</au><au>Seo, Hoonhee</au><au>Kim, Sukyung</au><au>Haq, Asad Ul</au><au>Bae, Sung Hae</au><au>Lee, Hyun‐Ji</au><au>Ju, Se Hee</au><au>Tajdozian, Hanieh</au><au>Rahim, Md Abdur</au><au>Ghorbanian, Fatemeh</au><au>Barman, Indrajeet</au><au>Yoon, Youjin</au><au>Jo, Sujin</au><au>Lee, Youngkyoung</au><au>Cho, Gyutae</au><au>Jo, Hyein</au><au>Kim, Mijung</au><au>Lee, Saebim</au><au>Song, Ho‐Yeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2024-01</date><risdate>2024</risdate><volume>23</volume><issue>1</issue><spage>215</spage><epage>226</epage><pages>215-226</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
The excessive production and accumulation of melanin in the epidermal skin layer can result in skin hyperpigmentation and darkening. Current technologies for regulating melanin are based on inhibiting melanin biosynthesis. They have low effectiveness and safety issues.
Aims
This study aimed to evaluate the potential role of Pediococcus acidilactici PMC48 as a probiotic strain in medicines and cosmetics for skin treatment.
Materials and Methods
Meanwhile, our research team has reported that P. acidilactici PMC48 strain isolated from sesame leaf kimchi can directly decompose the already synthesized melanin. It can also inhibit melanin biosynthesis. In the present study, we investigated the skin‐whitening effect of this strain by arranging an 8‐week clinical trial with 22 participants. PMC48 was applied to each participant's artificially UV‐induced tanned skin in the clinical trial. Its whitening effect was investigated based on visual evaluation, skin brightness, and melanin index.
Results
PMC48 showed a significant effect on the artificially induced pigmented skin. The color intensity of the tanned skin was decreased by 47.647%, and skin brightness was increased by 8.098% after the treatment period. PMC48 also significantly decreased the melanin index by 11.818%, indicating its tyrosinase inhibition capacity. Also, PMC48 improved skin moisture content level by 20.943%. Additionally, 16S rRNA‐based amplicon sequencing analysis showed a distinct increase in Lactobacillaceae in the skin by up to 11.2% at the family level without affecting other skin microbiota. Furthermore, it showed no toxicity in in vitro or in vivo analyses.
Discussion
These results indicate that P. acidilactici PMC48 is a promising probiotic strain that can be used to develop medicines and cosmetic products to solve skin‐related problems.
Conclusions
These results demonstrate that P. acidilactici PMC48 can be a potential probiotic for the cosmetic industry against different skin disorders.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>37381171</pmid><doi>10.1111/jocd.15891</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-5932-6633</orcidid><orcidid>https://orcid.org/0000-0001-5426-4050</orcidid><orcidid>https://orcid.org/0000-0002-3602-7980</orcidid><orcidid>https://orcid.org/0000-0002-9148-4535</orcidid><orcidid>https://orcid.org/0000-0002-7299-1240</orcidid><orcidid>https://orcid.org/0000-0003-4429-1383</orcidid><orcidid>https://orcid.org/0000-0002-1260-7702</orcidid><orcidid>https://orcid.org/0000-0002-7963-9776</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cosmetic dermatology, 2024-01, Vol.23 (1), p.215-226 |
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| language | eng |
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| source | Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete |
| subjects | Acids Clinical trials Cytotoxicity Dermatitis hyperpigmentation melanin microbiome Moisture content Oxidation Pediococcus acidilactici PMC48 Probiotics Skin Temperature |
| title | Clinical effect of Pediococcus acidilactici PMC48 on hyperpigmented skin |
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