Discovery of amphotericin B, an antifungal drug as tyrosinase inhibitor with potent anti-melanogenic activity

Tyrosinase, a rate-limiting enzyme for melanin production, has been the most efficient target for the development of depigmenting agents. Although hydroquinone, kojic acid, and arbutin are the most well-known tyrosinase inhibitors, their adverse effects are inevitable. In the present study, an in si...

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Veröffentlicht in:	International journal of biological macromolecules 2023-08, Vol.246, p.125587-125587, Article 125587
Hauptverfasser:	Mahalapbutr, Panupong, Sabuakham, Sahachai, Nasoontorn, Sutita, Rungrotmongkol, Thanyada, Silsirivanit, Atit, Suriya, Utid
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug repurposing MD simulation Melanogenesis
Online-Zugang:	Volltext
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