Diagnostic and Treatment Practices for Helicobacter Pylori Infection in an Academic Pediatric Hospital

In 2016, ESPGHAN/NASPGHAN issued revised guidelines for the management of Helicobacter pylori (H. pylori) infection in children and adolescents. Recommendations include performing antibiotic susceptibility testing to tailor therapy. The aim of our study was to evaluate the H. pylori treatment landsc...

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Veröffentlicht in:	Rhode Island medical journal (2013) 2023-07, Vol.106 (6), p.35-39
Hauptverfasser:	Riaz, Muhammad Safwan, Moss, Steven F, Shapiro, Jason M, Cerezo, Carolina, Herzlinger, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Amoxicillin - adverse effects Amoxicillin - therapeutic use Anti-Bacterial Agents - therapeutic use Child Clarithromycin - adverse effects Clarithromycin - therapeutic use Drug Therapy, Combination Helicobacter Infections - diagnosis Helicobacter Infections - drug therapy Helicobacter Infections - etiology Helicobacter pylori Hospitals, Pediatric Humans Metronidazole - therapeutic use Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - therapeutic use Retrospective Studies Treatment Outcome
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creator	Riaz, Muhammad Safwan Moss, Steven F Shapiro, Jason M Cerezo, Carolina Herzlinger, Michael
description	In 2016, ESPGHAN/NASPGHAN issued revised guidelines for the management of Helicobacter pylori (H. pylori) infection in children and adolescents. Recommendations include performing antibiotic susceptibility testing to tailor therapy. The aim of our study was to evaluate the H. pylori treatment landscape in pediatric patients at our institution. We performed a retrospective study of patients diagnosed with H. pylori infection at a single academic children's hospital from 2015 to 2021. The frequency of each treatment regimen and their respective eradication rates were calculated. We compared trends in antibiotic prescriptions and eradication rates before and after 2016. One hundred and ninety-six patients were included. Triple therapy with amoxicillin, clarithromycin, and a proton pump inhibiter (PPI) was the most often prescribed regimen (46.5%), followed by amoxicillin, metronidazole, and PPI (33%). Eradication rates were 70% for amoxicillin, clarithromycin, and PPI and 64% for amoxicillin, metronidazole, and PPI. Our results show eradication rates for both regimens were comparable but suboptimal, highlighting the need to incorporate resistance testing into broader practice.
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source	Freely Accessible Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Adolescent Amoxicillin - adverse effects Amoxicillin - therapeutic use Anti-Bacterial Agents - therapeutic use Child Clarithromycin - adverse effects Clarithromycin - therapeutic use Drug Therapy, Combination Helicobacter Infections - diagnosis Helicobacter Infections - drug therapy Helicobacter Infections - etiology Helicobacter pylori Hospitals, Pediatric Humans Metronidazole - therapeutic use Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - therapeutic use Retrospective Studies Treatment Outcome
title	Diagnostic and Treatment Practices for Helicobacter Pylori Infection in an Academic Pediatric Hospital
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