Overexpression of SMAD7 improves the function of EGFR‐targeted human CAR‐T cells against non‐small‐cell lung cancer

Background and Objective Recent advancements in immunotherapy led to the development of Chimeric antigen receptor (CAR) T‐cell therapy. CAR‐T cell therapy in non‐small cell lung cancer (NSCLC) is hindered by overexpression of transforming growth factor (TGFβ) in the cancer cells that have a negative...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Respirology (Carlton, Vic.) Vic.), 2023-09, Vol.28 (9), p.869-880
Hauptverfasser:	Li, Guoping, Liao, Guoliang, Xie, Jinbao, Liu, Bo, Li, Xu, Qiu, Minglian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies CAR‐T Cell proliferation Cell therapy chimeric antigen receptor T‐cell therapy Chimeric antigen receptors EGFR Epidermal growth factor receptors Growth factors Immunotherapy Inflammation Lung cancer Lung carcinoma Lymphocytes T Lysis mothers against decapentaplegic homologue 7 Non-small cell lung carcinoma non‐small‐cell lung cancer resistance Respiratory diseases Smad protein Smad7 protein Small cell lung carcinoma TGF Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!