Synthesis, characterization, and anticancer potency of branched poly (p-hydroxy styrene) Schiff-bases
A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediami...
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| Veröffentlicht in: | Macromolecular bioscience 2023-11, Vol.23 (11), p.e2300090-e2300090 |
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| container_title | Macromolecular bioscience |
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| creator | Kenawy, El-Refaie El-Khalafy, Sahar H Abosharaf, Hamed A El-Nshar, Esraa M Ghazy, Ahmad R Azaam, Mohamed M |
| description | A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR and elemental analysis, all synthesized Schiff-bases were identified and characterized. Further, the antineoplastic potential of all Schiff bases was evaluated against different cancer cell lines. The results gained from this study indicated that the Schiff base polymers had cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency was dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer showed potent cytotoxicity and was able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulated VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. This article is protected by copyright. All rights reserved. |
| doi_str_mv | 10.1002/mabi.202300090 |
| format | Article |
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Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR and elemental analysis, all synthesized Schiff-bases were identified and characterized. Further, the antineoplastic potential of all Schiff bases was evaluated against different cancer cell lines. The results gained from this study indicated that the Schiff base polymers had cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency was dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer showed potent cytotoxicity and was able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulated VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. This article is protected by copyright. All rights reserved.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.202300090</identifier><identifier>PMID: 37376773</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Aldehydes ; Apoptosis ; Cancer ; Chemical analysis ; Cytotoxicity ; Imines ; NMR ; Nuclear magnetic resonance ; Phenylenediamine ; Polymers ; Reactive oxygen species ; Styrene ; Styrenes ; Tumor cell lines ; Vascular endothelial growth factor receptors</subject><ispartof>Macromolecular bioscience, 2023-11, Vol.23 (11), p.e2300090-e2300090</ispartof><rights>This article is protected by copyright. All rights reserved.</rights><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-c56deac5ec06912e14b468670a477f56f7fe16f5957036eb8c93fdec82c796ab3</citedby><cites>FETCH-LOGICAL-c323t-c56deac5ec06912e14b468670a477f56f7fe16f5957036eb8c93fdec82c796ab3</cites><orcidid>0000-0003-3850-4258</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37376773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenawy, El-Refaie</creatorcontrib><creatorcontrib>El-Khalafy, Sahar H</creatorcontrib><creatorcontrib>Abosharaf, Hamed A</creatorcontrib><creatorcontrib>El-Nshar, Esraa M</creatorcontrib><creatorcontrib>Ghazy, Ahmad R</creatorcontrib><creatorcontrib>Azaam, Mohamed M</creatorcontrib><title>Synthesis, characterization, and anticancer potency of branched poly (p-hydroxy styrene) Schiff-bases</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR and elemental analysis, all synthesized Schiff-bases were identified and characterized. Further, the antineoplastic potential of all Schiff bases was evaluated against different cancer cell lines. The results gained from this study indicated that the Schiff base polymers had cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency was dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer showed potent cytotoxicity and was able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulated VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. This article is protected by copyright. All rights reserved.</description><subject>Aldehydes</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Chemical analysis</subject><subject>Cytotoxicity</subject><subject>Imines</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phenylenediamine</subject><subject>Polymers</subject><subject>Reactive oxygen species</subject><subject>Styrene</subject><subject>Styrenes</subject><subject>Tumor cell lines</subject><subject>Vascular endothelial growth factor receptors</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkc1Lw0AQxRdRbK1ePUrASwVTZ7PZ3eQoxS8oeKiew2YzS1Ly5e4WjH-9Ka09eBhmePzmMcwj5JrCggJED43Kq0UEEQOAFE7IlAoqQk5TfnqcEzkhF85tAKhM0uicTJhkUkjJpgTXQ-tLdJW7D3SprNIebfWjfNW194Fqi7F8pVWr0QZ957HVQ9CZILejVGIxavUQzPuwHArbfQ-B84PFFu-CtS4rY8JcOXSX5Myo2uHVoc_I5_PTx_I1XL2_vC0fV6FmEfOh5qJApTlqECmNkMZ5LBIhQcVSGi6MNEiF4SmXwATmiU6ZKVAnkZapUDmbkfnet7fd1xadz5rKaaxr1WK3dVmUMBCSSohH9PYfuum2th2vG6lEUA4JyJFa7CltO-csmqy3VaPskFHIdgFkuwCyYwDjws3Bdps3WBzxv4-zX6szgZ8</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Kenawy, El-Refaie</creator><creator>El-Khalafy, Sahar H</creator><creator>Abosharaf, Hamed A</creator><creator>El-Nshar, Esraa M</creator><creator>Ghazy, Ahmad R</creator><creator>Azaam, Mohamed M</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3850-4258</orcidid></search><sort><creationdate>20231101</creationdate><title>Synthesis, characterization, and anticancer potency of branched poly (p-hydroxy styrene) Schiff-bases</title><author>Kenawy, El-Refaie ; El-Khalafy, Sahar H ; Abosharaf, Hamed A ; El-Nshar, Esraa M ; Ghazy, Ahmad R ; Azaam, Mohamed M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-c56deac5ec06912e14b468670a477f56f7fe16f5957036eb8c93fdec82c796ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aldehydes</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Chemical analysis</topic><topic>Cytotoxicity</topic><topic>Imines</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phenylenediamine</topic><topic>Polymers</topic><topic>Reactive oxygen species</topic><topic>Styrene</topic><topic>Styrenes</topic><topic>Tumor cell lines</topic><topic>Vascular endothelial growth factor receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenawy, El-Refaie</creatorcontrib><creatorcontrib>El-Khalafy, Sahar H</creatorcontrib><creatorcontrib>Abosharaf, Hamed A</creatorcontrib><creatorcontrib>El-Nshar, Esraa M</creatorcontrib><creatorcontrib>Ghazy, Ahmad R</creatorcontrib><creatorcontrib>Azaam, Mohamed M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenawy, El-Refaie</au><au>El-Khalafy, Sahar H</au><au>Abosharaf, Hamed A</au><au>El-Nshar, Esraa M</au><au>Ghazy, Ahmad R</au><au>Azaam, Mohamed M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization, and anticancer potency of branched poly (p-hydroxy styrene) Schiff-bases</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>23</volume><issue>11</issue><spage>e2300090</spage><epage>e2300090</epage><pages>e2300090-e2300090</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) were created. The branched polymer was first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR and elemental analysis, all synthesized Schiff-bases were identified and characterized. Further, the antineoplastic potential of all Schiff bases was evaluated against different cancer cell lines. The results gained from this study indicated that the Schiff base polymers had cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency was dose-concentration dependent. Importantly, the prepared S1 Schiff-base polymer showed potent cytotoxicity and was able to trigger the apoptosis and reactive oxygen species (ROS) in MCF-7 cells. Further, it downregulated VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines. This article is protected by copyright. All rights reserved.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37376773</pmid><doi>10.1002/mabi.202300090</doi><orcidid>https://orcid.org/0000-0003-3850-4258</orcidid></addata></record> |
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| ispartof | Macromolecular bioscience, 2023-11, Vol.23 (11), p.e2300090-e2300090 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Aldehydes Apoptosis Cancer Chemical analysis Cytotoxicity Imines NMR Nuclear magnetic resonance Phenylenediamine Polymers Reactive oxygen species Styrene Styrenes Tumor cell lines Vascular endothelial growth factor receptors |
| title | Synthesis, characterization, and anticancer potency of branched poly (p-hydroxy styrene) Schiff-bases |
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