Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry

N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory synaptic transmission, are widely distributed throughout the central nervous system, and regulate synaptic plasticity. NMDA receptor modulators have long been considered as potential treatments for psychiatric disorders inc...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2024-01, Vol.49 (1), p.51-66
Hauptverfasser:	Hanson, Jesse E, Yuan, Hongjie, Perszyk, Riley E, Banke, Tue G, Xing, Hao, Tsai, Ming-Chi, Menniti, Frank S, Traynelis, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Alzheimer's disease Brain - metabolism Central Nervous System Glutamic acid receptors Glutamic acid receptors (ionotropic) Humans Mental disorders N-Methyl-D-aspartic acid receptors Neurodegenerative diseases Neurodevelopmental disorders Neuromodulation Psychiatry Receptor mechanisms Receptors, N-Methyl-D-Aspartate - metabolism Rett syndrome Schizophrenia Synaptic plasticity Synaptic transmission Therapeutic targets
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