Quantitative evaluation of retinal and choroidal vascularity in systemic lupus erythematosus by SS-OCT/OCTA
Purpose To evaluate changes in retinal and choroidal vascularity using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE). Methods In this prospective, cross-sectional study, 48 SLE patients and 4...
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| creator | Guo, Tingting Jin, Yihua Zhou, Min Lei, Boya Huang, Linlin Chen, Sheng Xue, Kang |
| description | Purpose
To evaluate changes in retinal and choroidal vascularity using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE).
Methods
In this prospective, cross-sectional study, 48 SLE patients and 40 healthy control (group HC) participants were included. The SLE patients were divided into two subgroups: patients with SLE with no ocular disease (group I) and patients with SLE with signs of retinopathy (group II). The superficial vessel density (SVD), deep vessel density (DVD), peripapillary retinal vessel densities (pRVD), choroidal thickness (ChT), and choroidal vascularity including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were measured using SS-OCT/OCTA. Physical and ophthalmic examinations as well as the assessments of immunological markers were performed. The results of SS-OCT/OCTA were compared between group I, group II, and group HC, while the correlations among the parameters were analyzed.
Results
The SVD, DVD, and pRVD were found to be significantly lower in SLE patients than group HC, especially in SLE patients with signs of retinopathy. ChT were found to be significantly higher in group II. CVI was positively correlated with SVD and DVD in the fovea, as well as the foveal and parafoveal thickness. A significant decrease in SVD and DVD in the fovea among subjects positive for anti-dsDNA antibodies was noted.
Conclusions
The application of OCTA in the evaluation of microvasculature may be useful in subclinical changes. Retinal microvascular density decreased in patients with SLE with greater severity of SLE. Disturbed retinal circulation was related to SLE disease activity, disease duration, CVI, and being positive for anti-dsDNA antibodies. The study results also suggest that SLE with signs of retinopathy may affect the choroid with increases in LA, SA, TCA, and ChT. |
| doi_str_mv | 10.1007/s00417-023-06155-5 |
| format | Article |
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To evaluate changes in retinal and choroidal vascularity using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE).
Methods
In this prospective, cross-sectional study, 48 SLE patients and 40 healthy control (group HC) participants were included. The SLE patients were divided into two subgroups: patients with SLE with no ocular disease (group I) and patients with SLE with signs of retinopathy (group II). The superficial vessel density (SVD), deep vessel density (DVD), peripapillary retinal vessel densities (pRVD), choroidal thickness (ChT), and choroidal vascularity including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were measured using SS-OCT/OCTA. Physical and ophthalmic examinations as well as the assessments of immunological markers were performed. The results of SS-OCT/OCTA were compared between group I, group II, and group HC, while the correlations among the parameters were analyzed.
Results
The SVD, DVD, and pRVD were found to be significantly lower in SLE patients than group HC, especially in SLE patients with signs of retinopathy. ChT were found to be significantly higher in group II. CVI was positively correlated with SVD and DVD in the fovea, as well as the foveal and parafoveal thickness. A significant decrease in SVD and DVD in the fovea among subjects positive for anti-dsDNA antibodies was noted.
Conclusions
The application of OCTA in the evaluation of microvasculature may be useful in subclinical changes. Retinal microvascular density decreased in patients with SLE with greater severity of SLE. Disturbed retinal circulation was related to SLE disease activity, disease duration, CVI, and being positive for anti-dsDNA antibodies. The study results also suggest that SLE with signs of retinopathy may affect the choroid with increases in LA, SA, TCA, and ChT.</description><identifier>ISSN: 0721-832X</identifier><identifier>ISSN: 1435-702X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-023-06155-5</identifier><identifier>PMID: 37367994</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiography ; Anti-DNA antibodies ; Blood vessels ; Choroid - blood supply ; Cross-Sectional Studies ; Eye diseases ; Fluorescein Angiography - methods ; Humans ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - diagnosis ; Medicine ; Medicine & Public Health ; Microvasculature ; Ophthalmology ; Prospective Studies ; Retina ; Retinal Diseases ; Retinal Disorders ; Retinal Vessels ; Retinopathy ; Systemic lupus erythematosus ; Tomography ; Tomography, Optical Coherence - methods</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2023-12, Vol.261 (12), p.3385-3393</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4da84208ba2621d93ca239ed762960f80bb33097731463ad34c3c9f4d7ac21843</citedby><cites>FETCH-LOGICAL-c375t-4da84208ba2621d93ca239ed762960f80bb33097731463ad34c3c9f4d7ac21843</cites><orcidid>0000-0003-4621-0217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-023-06155-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-023-06155-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37367994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Tingting</creatorcontrib><creatorcontrib>Jin, Yihua</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Lei, Boya</creatorcontrib><creatorcontrib>Huang, Linlin</creatorcontrib><creatorcontrib>Chen, Sheng</creatorcontrib><creatorcontrib>Xue, Kang</creatorcontrib><title>Quantitative evaluation of retinal and choroidal vascularity in systemic lupus erythematosus by SS-OCT/OCTA</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To evaluate changes in retinal and choroidal vascularity using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE).
Methods
In this prospective, cross-sectional study, 48 SLE patients and 40 healthy control (group HC) participants were included. The SLE patients were divided into two subgroups: patients with SLE with no ocular disease (group I) and patients with SLE with signs of retinopathy (group II). The superficial vessel density (SVD), deep vessel density (DVD), peripapillary retinal vessel densities (pRVD), choroidal thickness (ChT), and choroidal vascularity including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were measured using SS-OCT/OCTA. Physical and ophthalmic examinations as well as the assessments of immunological markers were performed. The results of SS-OCT/OCTA were compared between group I, group II, and group HC, while the correlations among the parameters were analyzed.
Results
The SVD, DVD, and pRVD were found to be significantly lower in SLE patients than group HC, especially in SLE patients with signs of retinopathy. ChT were found to be significantly higher in group II. CVI was positively correlated with SVD and DVD in the fovea, as well as the foveal and parafoveal thickness. A significant decrease in SVD and DVD in the fovea among subjects positive for anti-dsDNA antibodies was noted.
Conclusions
The application of OCTA in the evaluation of microvasculature may be useful in subclinical changes. Retinal microvascular density decreased in patients with SLE with greater severity of SLE. Disturbed retinal circulation was related to SLE disease activity, disease duration, CVI, and being positive for anti-dsDNA antibodies. The study results also suggest that SLE with signs of retinopathy may affect the choroid with increases in LA, SA, TCA, and ChT.</description><subject>Angiography</subject><subject>Anti-DNA antibodies</subject><subject>Blood vessels</subject><subject>Choroid - blood supply</subject><subject>Cross-Sectional Studies</subject><subject>Eye diseases</subject><subject>Fluorescein Angiography - methods</subject><subject>Humans</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Retina</subject><subject>Retinal Diseases</subject><subject>Retinal Disorders</subject><subject>Retinal Vessels</subject><subject>Retinopathy</subject><subject>Systemic lupus erythematosus</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><issn>0721-832X</issn><issn>1435-702X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rHSEUhqU0NLdJ_0AXReimGxv16DizDJf0AwIhJIHsxHGcxnRmvPXjwvz7mt60hS66EH3xOe_hnBeht4x-ZJSqs0SpYIpQDoQ2TEoiX6ANEyCJovz-JdpQxRlpgd8fo9cpPdLKg2Sv0DEoaFTXiQ36fl3Mkn022e8ddnszlfoMCw4jji77xUzYLAO2DyEGP1S1N8mWyUSfV-wXnNaU3ewtnsquJOzimh_cbHJIVfUrvrkhV9vbs3rOT9HRaKbk3jzfJ-ju08Xt9gu5vPr8dXt-SSwomYkYTCs4bXvDG86GDqzh0LlBNbxr6NjSvgegnVLARANmAGHBdqMYlLGctQJO0IeD7y6GH8WlrGefrJsms7hQkuYtUM5ZI1VF3_-DPoYS69BPVMfbujLJK8UPlI0hpehGvYt-NnHVjOqnKPQhCl2j0L-i0LIWvXu2Lv3shj8lv3dfATgAqX4t31z82_s_tj8BKa-T3A</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Guo, Tingting</creator><creator>Jin, Yihua</creator><creator>Zhou, Min</creator><creator>Lei, Boya</creator><creator>Huang, Linlin</creator><creator>Chen, Sheng</creator><creator>Xue, Kang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4621-0217</orcidid></search><sort><creationdate>20231201</creationdate><title>Quantitative evaluation of retinal and choroidal vascularity in systemic lupus erythematosus by SS-OCT/OCTA</title><author>Guo, Tingting ; 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To evaluate changes in retinal and choroidal vascularity using swept-source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) in patients with systemic lupus erythematosus (SLE).
Methods
In this prospective, cross-sectional study, 48 SLE patients and 40 healthy control (group HC) participants were included. The SLE patients were divided into two subgroups: patients with SLE with no ocular disease (group I) and patients with SLE with signs of retinopathy (group II). The superficial vessel density (SVD), deep vessel density (DVD), peripapillary retinal vessel densities (pRVD), choroidal thickness (ChT), and choroidal vascularity including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were measured using SS-OCT/OCTA. Physical and ophthalmic examinations as well as the assessments of immunological markers were performed. The results of SS-OCT/OCTA were compared between group I, group II, and group HC, while the correlations among the parameters were analyzed.
Results
The SVD, DVD, and pRVD were found to be significantly lower in SLE patients than group HC, especially in SLE patients with signs of retinopathy. ChT were found to be significantly higher in group II. CVI was positively correlated with SVD and DVD in the fovea, as well as the foveal and parafoveal thickness. A significant decrease in SVD and DVD in the fovea among subjects positive for anti-dsDNA antibodies was noted.
Conclusions
The application of OCTA in the evaluation of microvasculature may be useful in subclinical changes. Retinal microvascular density decreased in patients with SLE with greater severity of SLE. Disturbed retinal circulation was related to SLE disease activity, disease duration, CVI, and being positive for anti-dsDNA antibodies. The study results also suggest that SLE with signs of retinopathy may affect the choroid with increases in LA, SA, TCA, and ChT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37367994</pmid><doi>10.1007/s00417-023-06155-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4621-0217</orcidid></addata></record> |
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| subjects | Angiography Anti-DNA antibodies Blood vessels Choroid - blood supply Cross-Sectional Studies Eye diseases Fluorescein Angiography - methods Humans Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - diagnosis Medicine Medicine & Public Health Microvasculature Ophthalmology Prospective Studies Retina Retinal Diseases Retinal Disorders Retinal Vessels Retinopathy Systemic lupus erythematosus Tomography Tomography, Optical Coherence - methods |
| title | Quantitative evaluation of retinal and choroidal vascularity in systemic lupus erythematosus by SS-OCT/OCTA |
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