Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014
Objectives Oxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2023-06, Vol.27 (6), p.479-486 |
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| container_title | The Journal of nutrition, health & aging |
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| creator | Peng, M. Liu, Y. Jia, X. Wu, Y. Zou, X. Ke, M. Cai, K. Zhang, L. Lu, Dan Xu, Anding |
| description | Objectives
Oxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function of older adults in the U.S.
Design
A cross-sectional study.
Setting
National Health and Nutrition Examination Surveys database.
Participants
2712 older adults aged over 60 years.
Measurements
TAC was calculated from 8 antioxidative vitamins based on the reference values for vitamin C equivalent antioxidant capacity obtained from individuals’ 24 h dietary recall. Four memory-related assessments were employed [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)].
Results
Among the 2712 participants, the median age was 68 years, and 50.4% were women. Participants in the group with higher TAC levels had relatively higher IRT, AFT and DSST scores (P=0.025, P=0.008, P |
| doi_str_mv | 10.1007/s12603-023-1934-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2829705614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2829705614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-76a99ab6c870300c1a153e9744747728195211c96aa10ca58caa0672a78f7c2c3</originalsourceid><addsrcrecordid>eNp1kU1uFDEQRi0EIiFwADbIEhs2DS7b7bLZjYaEIEXJIpN1q-L2BEc97qHtjsiOO3BDToKHCSAhsSr_vPrK8mPsJYi3IAS-yyCNUI2QqgGndOMesUNAIxqN1j6ua4muQRR4wJ7lfCuEbp01T9mBQtWiUuqQ3X2IodB0z1djoYEvUonj19hTKnxJW_Kx3HNKPV-ONymWeBf4yZx8hRKPiV8MfZj4op-Hknf78jnwq8qFnl8WKiG_56t6dH66OD--5FIA_Pj2vRb9nD1Z05DDi4d6xK5OjlfL0-bs4uOn5eKs8Rra0qAh5-jaeItCCeGBoFXBodaoEaUF10oA7wwRCE-t9UTCoCS0a_TSqyP2Zp-7ncYvc8il28TswzBQCuOcO2mlQ9Ea0BV9_Q96O85Tqq_7RQEYa7FSsKf8NOY8hXW3neKmfmAHottJ6fZSuiql20npXO159ZA8X29C_6fjt4UKyD2Q61W6CdPf0f9P_QnRi5Rd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2829116887</pqid></control><display><type>article</type><title>Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Peng, M. ; Liu, Y. ; Jia, X. ; Wu, Y. ; Zou, X. ; Ke, M. ; Cai, K. ; Zhang, L. ; Lu, Dan ; Xu, Anding</creator><creatorcontrib>Peng, M. ; Liu, Y. ; Jia, X. ; Wu, Y. ; Zou, X. ; Ke, M. ; Cai, K. ; Zhang, L. ; Lu, Dan ; Xu, Anding</creatorcontrib><description>Objectives
Oxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function of older adults in the U.S.
Design
A cross-sectional study.
Setting
National Health and Nutrition Examination Surveys database.
Participants
2712 older adults aged over 60 years.
Measurements
TAC was calculated from 8 antioxidative vitamins based on the reference values for vitamin C equivalent antioxidant capacity obtained from individuals’ 24 h dietary recall. Four memory-related assessments were employed [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)].
Results
Among the 2712 participants, the median age was 68 years, and 50.4% were women. Participants in the group with higher TAC levels had relatively higher IRT, AFT and DSST scores (P=0.025, P=0.008, P<0.001, respectively). In adjusted weighted linear regression, log-transformed TAC was positively associated with AFT (β=1.10, 95%CI: 0.51, 1.70) and DSST (β=2.81, 95%CI: 1.16, 4.45). Compared with the first quartile, the participants in the second (Q2 vs. Q1, OR=0.66, 95%CI: 0.43,1.02) and fourth quartile (Q4 vs. Q1, OR=0.47, 95%CI:0.28, 0.78) of log-transformed TAC showed a decreased risk of impaired cognitive function (ICF) after adjusting for confounders. The dose-response analysis indicated a gradual descent in the risk of ICF as TAC increases. Diabetes mellitus (DM) mediated part of the effect of TAC on ICF. The relationship between TAC and ICF was more pronounced in subjects with DM (Q4 vs Q1, OR=0.36, 95%CI:0.17, 0.74).
Conclusion
Our findings support that higher dietary antioxidant potential was related to a decreased risk of cognitive dysfunction, particularly in the subjects with DM who may have oxidative injury. DM was one of the factors mediating the effect of TAC on ICF.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-023-1934-9</identifier><identifier>PMID: 37357333</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aging ; Animals ; Antioxidants ; Cognition - physiology ; Cognitive ability ; Cross-Sectional Studies ; Diet ; Female ; Geriatrics/Gerontology ; Male ; Medicine ; Medicine & Public Health ; Neurosciences ; Nutrition ; Nutrition Surveys ; Older people ; Original Research ; Oxidative stress ; Primary Care Medicine ; Quality of Life Research ; United States - epidemiology ; Vitamins</subject><ispartof>The Journal of nutrition, health & aging, 2023-06, Vol.27 (6), p.479-486</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-76a99ab6c870300c1a153e9744747728195211c96aa10ca58caa0672a78f7c2c3</citedby><cites>FETCH-LOGICAL-c415t-76a99ab6c870300c1a153e9744747728195211c96aa10ca58caa0672a78f7c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-023-1934-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-023-1934-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37357333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, M.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><creatorcontrib>Jia, X.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Zou, X.</creatorcontrib><creatorcontrib>Ke, M.</creatorcontrib><creatorcontrib>Cai, K.</creatorcontrib><creatorcontrib>Zhang, L.</creatorcontrib><creatorcontrib>Lu, Dan</creatorcontrib><creatorcontrib>Xu, Anding</creatorcontrib><title>Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
Oxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function of older adults in the U.S.
Design
A cross-sectional study.
Setting
National Health and Nutrition Examination Surveys database.
Participants
2712 older adults aged over 60 years.
Measurements
TAC was calculated from 8 antioxidative vitamins based on the reference values for vitamin C equivalent antioxidant capacity obtained from individuals’ 24 h dietary recall. Four memory-related assessments were employed [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)].
Results
Among the 2712 participants, the median age was 68 years, and 50.4% were women. Participants in the group with higher TAC levels had relatively higher IRT, AFT and DSST scores (P=0.025, P=0.008, P<0.001, respectively). In adjusted weighted linear regression, log-transformed TAC was positively associated with AFT (β=1.10, 95%CI: 0.51, 1.70) and DSST (β=2.81, 95%CI: 1.16, 4.45). Compared with the first quartile, the participants in the second (Q2 vs. Q1, OR=0.66, 95%CI: 0.43,1.02) and fourth quartile (Q4 vs. Q1, OR=0.47, 95%CI:0.28, 0.78) of log-transformed TAC showed a decreased risk of impaired cognitive function (ICF) after adjusting for confounders. The dose-response analysis indicated a gradual descent in the risk of ICF as TAC increases. Diabetes mellitus (DM) mediated part of the effect of TAC on ICF. The relationship between TAC and ICF was more pronounced in subjects with DM (Q4 vs Q1, OR=0.36, 95%CI:0.17, 0.74).
Conclusion
Our findings support that higher dietary antioxidant potential was related to a decreased risk of cognitive dysfunction, particularly in the subjects with DM who may have oxidative injury. DM was one of the factors mediating the effect of TAC on ICF.</description><subject>Aging</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Older people</subject><subject>Original Research</subject><subject>Oxidative stress</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>United States - epidemiology</subject><subject>Vitamins</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1uFDEQRi0EIiFwADbIEhs2DS7b7bLZjYaEIEXJIpN1q-L2BEc97qHtjsiOO3BDToKHCSAhsSr_vPrK8mPsJYi3IAS-yyCNUI2QqgGndOMesUNAIxqN1j6ua4muQRR4wJ7lfCuEbp01T9mBQtWiUuqQ3X2IodB0z1djoYEvUonj19hTKnxJW_Kx3HNKPV-ONymWeBf4yZx8hRKPiV8MfZj4op-Hknf78jnwq8qFnl8WKiG_56t6dH66OD--5FIA_Pj2vRb9nD1Z05DDi4d6xK5OjlfL0-bs4uOn5eKs8Rra0qAh5-jaeItCCeGBoFXBodaoEaUF10oA7wwRCE-t9UTCoCS0a_TSqyP2Zp-7ncYvc8il28TswzBQCuOcO2mlQ9Ea0BV9_Q96O85Tqq_7RQEYa7FSsKf8NOY8hXW3neKmfmAHottJ6fZSuiql20npXO159ZA8X29C_6fjt4UKyD2Q61W6CdPf0f9P_QnRi5Rd</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Peng, M.</creator><creator>Liu, Y.</creator><creator>Jia, X.</creator><creator>Wu, Y.</creator><creator>Zou, X.</creator><creator>Ke, M.</creator><creator>Cai, K.</creator><creator>Zhang, L.</creator><creator>Lu, Dan</creator><creator>Xu, Anding</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230601</creationdate><title>Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014</title><author>Peng, M. ; Liu, Y. ; Jia, X. ; Wu, Y. ; Zou, X. ; Ke, M. ; Cai, K. ; Zhang, L. ; Lu, Dan ; Xu, Anding</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-76a99ab6c870300c1a153e9744747728195211c96aa10ca58caa0672a78f7c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Nutrition Surveys</topic><topic>Older people</topic><topic>Original Research</topic><topic>Oxidative stress</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>United States - epidemiology</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, M.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><creatorcontrib>Jia, X.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Zou, X.</creatorcontrib><creatorcontrib>Ke, M.</creatorcontrib><creatorcontrib>Cai, K.</creatorcontrib><creatorcontrib>Zhang, L.</creatorcontrib><creatorcontrib>Lu, Dan</creatorcontrib><creatorcontrib>Xu, Anding</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, M.</au><au>Liu, Y.</au><au>Jia, X.</au><au>Wu, Y.</au><au>Zou, X.</au><au>Ke, M.</au><au>Cai, K.</au><au>Zhang, L.</au><au>Lu, Dan</au><au>Xu, Anding</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>27</volume><issue>6</issue><spage>479</spage><epage>486</epage><pages>479-486</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
Oxidative stress level takes part in the development of cognitive decline. However, the association between total antioxidant capacity (TAC) from diet and cognitive function is controversial. The aim of this study was to investigate the relationship between TAC and the cognitive function of older adults in the U.S.
Design
A cross-sectional study.
Setting
National Health and Nutrition Examination Surveys database.
Participants
2712 older adults aged over 60 years.
Measurements
TAC was calculated from 8 antioxidative vitamins based on the reference values for vitamin C equivalent antioxidant capacity obtained from individuals’ 24 h dietary recall. Four memory-related assessments were employed [Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST)].
Results
Among the 2712 participants, the median age was 68 years, and 50.4% were women. Participants in the group with higher TAC levels had relatively higher IRT, AFT and DSST scores (P=0.025, P=0.008, P<0.001, respectively). In adjusted weighted linear regression, log-transformed TAC was positively associated with AFT (β=1.10, 95%CI: 0.51, 1.70) and DSST (β=2.81, 95%CI: 1.16, 4.45). Compared with the first quartile, the participants in the second (Q2 vs. Q1, OR=0.66, 95%CI: 0.43,1.02) and fourth quartile (Q4 vs. Q1, OR=0.47, 95%CI:0.28, 0.78) of log-transformed TAC showed a decreased risk of impaired cognitive function (ICF) after adjusting for confounders. The dose-response analysis indicated a gradual descent in the risk of ICF as TAC increases. Diabetes mellitus (DM) mediated part of the effect of TAC on ICF. The relationship between TAC and ICF was more pronounced in subjects with DM (Q4 vs Q1, OR=0.36, 95%CI:0.17, 0.74).
Conclusion
Our findings support that higher dietary antioxidant potential was related to a decreased risk of cognitive dysfunction, particularly in the subjects with DM who may have oxidative injury. DM was one of the factors mediating the effect of TAC on ICF.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>37357333</pmid><doi>10.1007/s12603-023-1934-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, health & aging, 2023-06, Vol.27 (6), p.479-486 |
| issn | 1279-7707 1760-4788 |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Aging Animals Antioxidants Cognition - physiology Cognitive ability Cross-Sectional Studies Diet Female Geriatrics/Gerontology Male Medicine Medicine & Public Health Neurosciences Nutrition Nutrition Surveys Older people Original Research Oxidative stress Primary Care Medicine Quality of Life Research United States - epidemiology Vitamins |
| title | Dietary Total Antioxidant Capacity and Cognitive Function in Older Adults in the United States: The NHANES 2011–2014 |
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