Animal models of kidney iron overload and ferroptosis: a review of the literature
In recent years, it has been identified that excess iron contributes to the development of various pathologies and their complications. Kidney diseases do not escape the toxic effects of iron, and ferroptosis is identified as a pathophysiological mechanism that could be a therapeutic target to avoid...
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| Veröffentlicht in: | Biometals 2023-12, Vol.36 (6), p.1173-1187 |
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| creator | Ríos-Silva, Mónica Cárdenas, Yolitzy Ortega-Macías, Alan Gabriel Trujillo, Xóchitl Murillo-Zamora, Efrén Mendoza-Cano, Oliver Bricio-Barrios, Jaime Alberto Ibarra, Isabel Huerta, Miguel |
| description | In recent years, it has been identified that excess iron contributes to the development of various pathologies and their complications. Kidney diseases do not escape the toxic effects of iron, and ferroptosis is identified as a pathophysiological mechanism that could be a therapeutic target to avoid damage or progression of kidney disease. Ferroptosis is cell death associated with iron-dependent oxidative stress. To study the effects of iron overload (IOL) in the kidney, numerous animal models have been developed. The methodological differences between these models should reflect the IOL-generating mechanisms associated with human IOL diseases. A careful choice of animal model should be considered for translational purposes. |
| doi_str_mv | 10.1007/s10534-023-00518-5 |
| format | Article |
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Kidney diseases do not escape the toxic effects of iron, and ferroptosis is identified as a pathophysiological mechanism that could be a therapeutic target to avoid damage or progression of kidney disease. Ferroptosis is cell death associated with iron-dependent oxidative stress. To study the effects of iron overload (IOL) in the kidney, numerous animal models have been developed. The methodological differences between these models should reflect the IOL-generating mechanisms associated with human IOL diseases. A careful choice of animal model should be considered for translational purposes.</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-023-00518-5</identifier><identifier>PMID: 37356039</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal models ; Animals ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Cancer ; Cell Biology ; Cell death ; Diet ; Ferroptosis ; Homeostasis ; Humans ; Iron ; Iron Overload ; Kidney ; Kidney diseases ; Kidneys ; Life Sciences ; Lipid peroxidation ; Literature reviews ; Medicine/Public Health ; Microbiology ; Models, Animal ; Overloading ; Oxidative stress ; Pathophysiology ; Pharmacology/Toxicology ; Plant Physiology ; Review ; Therapeutic targets</subject><ispartof>Biometals, 2023-12, Vol.36 (6), p.1173-1187</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. 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Kidney diseases do not escape the toxic effects of iron, and ferroptosis is identified as a pathophysiological mechanism that could be a therapeutic target to avoid damage or progression of kidney disease. Ferroptosis is cell death associated with iron-dependent oxidative stress. To study the effects of iron overload (IOL) in the kidney, numerous animal models have been developed. The methodological differences between these models should reflect the IOL-generating mechanisms associated with human IOL diseases. A careful choice of animal model should be considered for translational purposes.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Diet</subject><subject>Ferroptosis</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron Overload</subject><subject>Kidney</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Literature reviews</subject><subject>Medicine/Public Health</subject><subject>Microbiology</subject><subject>Models, Animal</subject><subject>Overloading</subject><subject>Oxidative stress</subject><subject>Pathophysiology</subject><subject>Pharmacology/Toxicology</subject><subject>Plant 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| source | MEDLINE; SpringerLink Journals |
| subjects | Animal models Animals Biochemistry Biomarkers Biomedical and Life Sciences Cancer Cell Biology Cell death Diet Ferroptosis Homeostasis Humans Iron Iron Overload Kidney Kidney diseases Kidneys Life Sciences Lipid peroxidation Literature reviews Medicine/Public Health Microbiology Models, Animal Overloading Oxidative stress Pathophysiology Pharmacology/Toxicology Plant Physiology Review Therapeutic targets |
| title | Animal models of kidney iron overload and ferroptosis: a review of the literature |
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