Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients
OSA has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored. Are OSA and CPAP treatment associated independently with a poor prognosis for cutaneous melanoma? Four hundred for...
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| Veröffentlicht in: | Chest 2023-12, Vol.164 (6), p.1551-1559 |
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| creator | Gómez-Olivas, Jose Daniel Campos-Rodriguez, Francisco Nagore, Eduardo Martorell, Antonio García-Rio, Francisco Cubillos, Carolina Hernandez, Luis Bañuls, Jose Arias, Eva Ortiz, Pablo Cabriada, Valentin Gardeazabal, Juan Montserrat, Josep Maria Carrera, Cristina Masa, Juan Fernando Gomez de Terreros, Javier Abad, Jorge Boada, Adam Mediano, Olga Castillo-Garcia, Marta Chiner, Eusebi Landete, Pedro Mayos, Mercedes Fortuna, Ana Barbé, Ferrán Sanchez-de-la-Torre, Manuel Cano-Pumarega, Irene Perez-Gil, Amalia Gomez-Garcia, Teresa Cullen, Daniela Somoza, Maria Formigon, Manuel Aizpuru, Felipe Oscullo, Grace Garcia-Ortega, Alberto Almendros, Isaac Farré, Ramón Gozal, David Martinez-Garcia, Miguel Angel |
| description | OSA has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.
Are OSA and CPAP treatment associated independently with a poor prognosis for cutaneous melanoma?
Four hundred forty-three patients with a diagnosis of cutaneous melanoma (2012-2015) underwent a sleep study within 6 months of diagnosis. The main 5-year outcome of the study was a composite of melanoma recurrence, metastasis, or mortality. Patients were divided into four groups: baseline apnea-hypopnea index (AHI) of fewer than 10 events/h (no OSA; control group), OSA treated with CPAP and good adherence, untreated or poor CPAP adherence in moderate (AHI, 10-29 events/h), and severe OSA (AHI, ≥ 30 events/h). Survival analysis was used to determine the independent role of OSA and CPAP treatment on melanoma composite outcome.
Three hundred ninety-one patients (88.2%) were available for analysis at 5-year follow-up (mean age, 65.1 ± 15.2 years; 49% male; Breslow index, 1.7 ± 2.5 mm). One hundred thirty-nine patients had AHI of fewer than 10 events/h (control group); 78 patients with OSA were adherent to CPAP; and 124 and 50 patients had moderate and severe OSA, respectively, without CPAP treatment. Median follow-up was 60 months (interquartile range, 51-74 months). During follow-up, 32 relapses, 53 metastases, and 52 deaths occurred (116 patients showed at least one of the main composite outcomes). After adjusting for age, sex, sentinel lymph nodes affected at diagnosis, BMI, diabetes, nighttime with an oxygen saturation below 90%, Breslow index, Epworth sleepiness scale scores, and melanoma treatment, moderate (hazard ratio [HR], 2.45; 95% CI, 1.09-5.49) and severe OSA (HR, 2.96; 95% CI, 1.36-6.42) were associated with poorer prognosis of melanoma compared with the control group. However, good adherence to CPAP avoided this excess risk (HR, 1.66; 95% CI, 0.71-3.90).
Moderate to severe untreated OSA is an independent risk factor for poor prognosis of melanoma. Treatment with CPAP is associated with improved melanoma outcomes compared with untreated moderate to severe OSA. |
| doi_str_mv | 10.1016/j.chest.2023.06.012 |
| format | Article |
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Are OSA and CPAP treatment associated independently with a poor prognosis for cutaneous melanoma?
Four hundred forty-three patients with a diagnosis of cutaneous melanoma (2012-2015) underwent a sleep study within 6 months of diagnosis. The main 5-year outcome of the study was a composite of melanoma recurrence, metastasis, or mortality. Patients were divided into four groups: baseline apnea-hypopnea index (AHI) of fewer than 10 events/h (no OSA; control group), OSA treated with CPAP and good adherence, untreated or poor CPAP adherence in moderate (AHI, 10-29 events/h), and severe OSA (AHI, ≥ 30 events/h). Survival analysis was used to determine the independent role of OSA and CPAP treatment on melanoma composite outcome.
Three hundred ninety-one patients (88.2%) were available for analysis at 5-year follow-up (mean age, 65.1 ± 15.2 years; 49% male; Breslow index, 1.7 ± 2.5 mm). One hundred thirty-nine patients had AHI of fewer than 10 events/h (control group); 78 patients with OSA were adherent to CPAP; and 124 and 50 patients had moderate and severe OSA, respectively, without CPAP treatment. Median follow-up was 60 months (interquartile range, 51-74 months). During follow-up, 32 relapses, 53 metastases, and 52 deaths occurred (116 patients showed at least one of the main composite outcomes). After adjusting for age, sex, sentinel lymph nodes affected at diagnosis, BMI, diabetes, nighttime with an oxygen saturation below 90%, Breslow index, Epworth sleepiness scale scores, and melanoma treatment, moderate (hazard ratio [HR], 2.45; 95% CI, 1.09-5.49) and severe OSA (HR, 2.96; 95% CI, 1.36-6.42) were associated with poorer prognosis of melanoma compared with the control group. However, good adherence to CPAP avoided this excess risk (HR, 1.66; 95% CI, 0.71-3.90).
Moderate to severe untreated OSA is an independent risk factor for poor prognosis of melanoma. Treatment with CPAP is associated with improved melanoma outcomes compared with untreated moderate to severe OSA.</description><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1016/j.chest.2023.06.012</identifier><identifier>PMID: 37348828</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Aged, 80 and over ; Continuous Positive Airway Pressure ; Female ; Humans ; Male ; Melanoma - complications ; Melanoma - therapy ; Middle Aged ; Neoplasm Recurrence, Local - epidemiology ; Prognosis ; Prospective Studies ; Skin Neoplasms - complications ; Sleep Apnea Syndromes - complications ; Sleep Apnea, Obstructive - complications</subject><ispartof>Chest, 2023-12, Vol.164 (6), p.1551-1559</ispartof><rights>Copyright © 2023 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37348828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez-Olivas, Jose Daniel</creatorcontrib><creatorcontrib>Campos-Rodriguez, Francisco</creatorcontrib><creatorcontrib>Nagore, Eduardo</creatorcontrib><creatorcontrib>Martorell, Antonio</creatorcontrib><creatorcontrib>García-Rio, Francisco</creatorcontrib><creatorcontrib>Cubillos, Carolina</creatorcontrib><creatorcontrib>Hernandez, Luis</creatorcontrib><creatorcontrib>Bañuls, Jose</creatorcontrib><creatorcontrib>Arias, Eva</creatorcontrib><creatorcontrib>Ortiz, Pablo</creatorcontrib><creatorcontrib>Cabriada, Valentin</creatorcontrib><creatorcontrib>Gardeazabal, Juan</creatorcontrib><creatorcontrib>Montserrat, Josep Maria</creatorcontrib><creatorcontrib>Carrera, Cristina</creatorcontrib><creatorcontrib>Masa, Juan Fernando</creatorcontrib><creatorcontrib>Gomez de Terreros, Javier</creatorcontrib><creatorcontrib>Abad, Jorge</creatorcontrib><creatorcontrib>Boada, Adam</creatorcontrib><creatorcontrib>Mediano, Olga</creatorcontrib><creatorcontrib>Castillo-Garcia, Marta</creatorcontrib><creatorcontrib>Chiner, Eusebi</creatorcontrib><creatorcontrib>Landete, Pedro</creatorcontrib><creatorcontrib>Mayos, Mercedes</creatorcontrib><creatorcontrib>Fortuna, Ana</creatorcontrib><creatorcontrib>Barbé, Ferrán</creatorcontrib><creatorcontrib>Sanchez-de-la-Torre, Manuel</creatorcontrib><creatorcontrib>Cano-Pumarega, Irene</creatorcontrib><creatorcontrib>Perez-Gil, Amalia</creatorcontrib><creatorcontrib>Gomez-Garcia, Teresa</creatorcontrib><creatorcontrib>Cullen, Daniela</creatorcontrib><creatorcontrib>Somoza, Maria</creatorcontrib><creatorcontrib>Formigon, Manuel</creatorcontrib><creatorcontrib>Aizpuru, Felipe</creatorcontrib><creatorcontrib>Oscullo, Grace</creatorcontrib><creatorcontrib>Garcia-Ortega, Alberto</creatorcontrib><creatorcontrib>Almendros, Isaac</creatorcontrib><creatorcontrib>Farré, Ramón</creatorcontrib><creatorcontrib>Gozal, David</creatorcontrib><creatorcontrib>Martinez-Garcia, Miguel Angel</creatorcontrib><title>Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients</title><title>Chest</title><addtitle>Chest</addtitle><description>OSA has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.
Are OSA and CPAP treatment associated independently with a poor prognosis for cutaneous melanoma?
Four hundred forty-three patients with a diagnosis of cutaneous melanoma (2012-2015) underwent a sleep study within 6 months of diagnosis. The main 5-year outcome of the study was a composite of melanoma recurrence, metastasis, or mortality. Patients were divided into four groups: baseline apnea-hypopnea index (AHI) of fewer than 10 events/h (no OSA; control group), OSA treated with CPAP and good adherence, untreated or poor CPAP adherence in moderate (AHI, 10-29 events/h), and severe OSA (AHI, ≥ 30 events/h). Survival analysis was used to determine the independent role of OSA and CPAP treatment on melanoma composite outcome.
Three hundred ninety-one patients (88.2%) were available for analysis at 5-year follow-up (mean age, 65.1 ± 15.2 years; 49% male; Breslow index, 1.7 ± 2.5 mm). One hundred thirty-nine patients had AHI of fewer than 10 events/h (control group); 78 patients with OSA were adherent to CPAP; and 124 and 50 patients had moderate and severe OSA, respectively, without CPAP treatment. Median follow-up was 60 months (interquartile range, 51-74 months). During follow-up, 32 relapses, 53 metastases, and 52 deaths occurred (116 patients showed at least one of the main composite outcomes). After adjusting for age, sex, sentinel lymph nodes affected at diagnosis, BMI, diabetes, nighttime with an oxygen saturation below 90%, Breslow index, Epworth sleepiness scale scores, and melanoma treatment, moderate (hazard ratio [HR], 2.45; 95% CI, 1.09-5.49) and severe OSA (HR, 2.96; 95% CI, 1.36-6.42) were associated with poorer prognosis of melanoma compared with the control group. However, good adherence to CPAP avoided this excess risk (HR, 1.66; 95% CI, 0.71-3.90).
Moderate to severe untreated OSA is an independent risk factor for poor prognosis of melanoma. Treatment with CPAP is associated with improved melanoma outcomes compared with untreated moderate to severe OSA.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Continuous Positive Airway Pressure</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma - complications</subject><subject>Melanoma - therapy</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Skin Neoplasms - complications</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Apnea, Obstructive - complications</subject><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN1Kw0AQRhdBbK0-gSB76U3i7k6abLwLxT-oGGzFy7DJTtqUJBuzG6Hv4EObYvVq4JtzhuEj5IoznzMe3u78YovW-YIJ8FnoMy5OyJTHwD2YBzAh59buGGOcx-EZmUAEgZRCTsn3m6mRmpKuasSOJl2LiqpW06VpN94a-4Yu0iSl6x6Va7B1tGqp2yJNe7Npja3sQU6Vq8adpR-V29IXrFVrGnVHkwNmOyxc9YX0ZahdVYwc9nTlBr0_qEEA__oFOS1VbfHyOGfk_eF-vXjylq-Pz4tk6XWCc-cFqojmWueRgAJhjiIvCgkqjJgGlkutIw0hlFKEoQgRpOR5KaMxQR5I0AJm5Ob3btebz2HsLWsqW2A9vo1msJmQIg5ELAFG9PqIDnmDOuv6qlH9PvtrEH4AiJhyUw</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Gómez-Olivas, Jose Daniel</creator><creator>Campos-Rodriguez, Francisco</creator><creator>Nagore, Eduardo</creator><creator>Martorell, Antonio</creator><creator>García-Rio, Francisco</creator><creator>Cubillos, Carolina</creator><creator>Hernandez, Luis</creator><creator>Bañuls, Jose</creator><creator>Arias, Eva</creator><creator>Ortiz, Pablo</creator><creator>Cabriada, Valentin</creator><creator>Gardeazabal, Juan</creator><creator>Montserrat, Josep Maria</creator><creator>Carrera, Cristina</creator><creator>Masa, Juan Fernando</creator><creator>Gomez de Terreros, Javier</creator><creator>Abad, Jorge</creator><creator>Boada, Adam</creator><creator>Mediano, Olga</creator><creator>Castillo-Garcia, Marta</creator><creator>Chiner, Eusebi</creator><creator>Landete, Pedro</creator><creator>Mayos, Mercedes</creator><creator>Fortuna, Ana</creator><creator>Barbé, Ferrán</creator><creator>Sanchez-de-la-Torre, Manuel</creator><creator>Cano-Pumarega, Irene</creator><creator>Perez-Gil, Amalia</creator><creator>Gomez-Garcia, Teresa</creator><creator>Cullen, Daniela</creator><creator>Somoza, Maria</creator><creator>Formigon, Manuel</creator><creator>Aizpuru, Felipe</creator><creator>Oscullo, Grace</creator><creator>Garcia-Ortega, Alberto</creator><creator>Almendros, Isaac</creator><creator>Farré, Ramón</creator><creator>Gozal, David</creator><creator>Martinez-Garcia, Miguel Angel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202312</creationdate><title>Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients</title><author>Gómez-Olivas, Jose Daniel ; Campos-Rodriguez, Francisco ; Nagore, Eduardo ; Martorell, Antonio ; García-Rio, Francisco ; Cubillos, Carolina ; Hernandez, Luis ; Bañuls, Jose ; Arias, Eva ; Ortiz, Pablo ; Cabriada, Valentin ; Gardeazabal, Juan ; Montserrat, Josep Maria ; Carrera, Cristina ; Masa, Juan Fernando ; Gomez de Terreros, Javier ; Abad, Jorge ; Boada, Adam ; Mediano, Olga ; Castillo-Garcia, Marta ; Chiner, Eusebi ; Landete, Pedro ; Mayos, Mercedes ; Fortuna, Ana ; Barbé, Ferrán ; Sanchez-de-la-Torre, Manuel ; Cano-Pumarega, Irene ; Perez-Gil, Amalia ; Gomez-Garcia, Teresa ; Cullen, Daniela ; Somoza, Maria ; Formigon, Manuel ; Aizpuru, Felipe ; Oscullo, Grace ; Garcia-Ortega, Alberto ; Almendros, Isaac ; Farré, Ramón ; Gozal, David ; Martinez-Garcia, Miguel Angel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-4ac75ddb723ce35e2bcc83a670d30b8dd7d363f826626e3881bf8763fe1483d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Continuous Positive Airway Pressure</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma - complications</topic><topic>Melanoma - therapy</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Skin Neoplasms - complications</topic><topic>Sleep Apnea Syndromes - complications</topic><topic>Sleep Apnea, Obstructive - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez-Olivas, Jose Daniel</creatorcontrib><creatorcontrib>Campos-Rodriguez, Francisco</creatorcontrib><creatorcontrib>Nagore, Eduardo</creatorcontrib><creatorcontrib>Martorell, Antonio</creatorcontrib><creatorcontrib>García-Rio, Francisco</creatorcontrib><creatorcontrib>Cubillos, Carolina</creatorcontrib><creatorcontrib>Hernandez, Luis</creatorcontrib><creatorcontrib>Bañuls, Jose</creatorcontrib><creatorcontrib>Arias, Eva</creatorcontrib><creatorcontrib>Ortiz, Pablo</creatorcontrib><creatorcontrib>Cabriada, Valentin</creatorcontrib><creatorcontrib>Gardeazabal, Juan</creatorcontrib><creatorcontrib>Montserrat, Josep Maria</creatorcontrib><creatorcontrib>Carrera, Cristina</creatorcontrib><creatorcontrib>Masa, Juan Fernando</creatorcontrib><creatorcontrib>Gomez de Terreros, Javier</creatorcontrib><creatorcontrib>Abad, Jorge</creatorcontrib><creatorcontrib>Boada, Adam</creatorcontrib><creatorcontrib>Mediano, Olga</creatorcontrib><creatorcontrib>Castillo-Garcia, Marta</creatorcontrib><creatorcontrib>Chiner, Eusebi</creatorcontrib><creatorcontrib>Landete, Pedro</creatorcontrib><creatorcontrib>Mayos, Mercedes</creatorcontrib><creatorcontrib>Fortuna, Ana</creatorcontrib><creatorcontrib>Barbé, Ferrán</creatorcontrib><creatorcontrib>Sanchez-de-la-Torre, Manuel</creatorcontrib><creatorcontrib>Cano-Pumarega, Irene</creatorcontrib><creatorcontrib>Perez-Gil, Amalia</creatorcontrib><creatorcontrib>Gomez-Garcia, Teresa</creatorcontrib><creatorcontrib>Cullen, Daniela</creatorcontrib><creatorcontrib>Somoza, Maria</creatorcontrib><creatorcontrib>Formigon, Manuel</creatorcontrib><creatorcontrib>Aizpuru, Felipe</creatorcontrib><creatorcontrib>Oscullo, Grace</creatorcontrib><creatorcontrib>Garcia-Ortega, Alberto</creatorcontrib><creatorcontrib>Almendros, Isaac</creatorcontrib><creatorcontrib>Farré, Ramón</creatorcontrib><creatorcontrib>Gozal, David</creatorcontrib><creatorcontrib>Martinez-Garcia, Miguel Angel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez-Olivas, Jose Daniel</au><au>Campos-Rodriguez, Francisco</au><au>Nagore, Eduardo</au><au>Martorell, Antonio</au><au>García-Rio, Francisco</au><au>Cubillos, Carolina</au><au>Hernandez, Luis</au><au>Bañuls, Jose</au><au>Arias, Eva</au><au>Ortiz, Pablo</au><au>Cabriada, Valentin</au><au>Gardeazabal, Juan</au><au>Montserrat, Josep Maria</au><au>Carrera, Cristina</au><au>Masa, Juan Fernando</au><au>Gomez de Terreros, Javier</au><au>Abad, Jorge</au><au>Boada, Adam</au><au>Mediano, Olga</au><au>Castillo-Garcia, Marta</au><au>Chiner, Eusebi</au><au>Landete, Pedro</au><au>Mayos, Mercedes</au><au>Fortuna, Ana</au><au>Barbé, Ferrán</au><au>Sanchez-de-la-Torre, Manuel</au><au>Cano-Pumarega, Irene</au><au>Perez-Gil, Amalia</au><au>Gomez-Garcia, Teresa</au><au>Cullen, Daniela</au><au>Somoza, Maria</au><au>Formigon, Manuel</au><au>Aizpuru, Felipe</au><au>Oscullo, Grace</au><au>Garcia-Ortega, Alberto</au><au>Almendros, Isaac</au><au>Farré, Ramón</au><au>Gozal, David</au><au>Martinez-Garcia, Miguel Angel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2023-12</date><risdate>2023</risdate><volume>164</volume><issue>6</issue><spage>1551</spage><epage>1559</epage><pages>1551-1559</pages><eissn>1931-3543</eissn><abstract>OSA has been associated with increased incidence and aggressiveness of melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of melanoma remains unexplored.
Are OSA and CPAP treatment associated independently with a poor prognosis for cutaneous melanoma?
Four hundred forty-three patients with a diagnosis of cutaneous melanoma (2012-2015) underwent a sleep study within 6 months of diagnosis. The main 5-year outcome of the study was a composite of melanoma recurrence, metastasis, or mortality. Patients were divided into four groups: baseline apnea-hypopnea index (AHI) of fewer than 10 events/h (no OSA; control group), OSA treated with CPAP and good adherence, untreated or poor CPAP adherence in moderate (AHI, 10-29 events/h), and severe OSA (AHI, ≥ 30 events/h). Survival analysis was used to determine the independent role of OSA and CPAP treatment on melanoma composite outcome.
Three hundred ninety-one patients (88.2%) were available for analysis at 5-year follow-up (mean age, 65.1 ± 15.2 years; 49% male; Breslow index, 1.7 ± 2.5 mm). One hundred thirty-nine patients had AHI of fewer than 10 events/h (control group); 78 patients with OSA were adherent to CPAP; and 124 and 50 patients had moderate and severe OSA, respectively, without CPAP treatment. Median follow-up was 60 months (interquartile range, 51-74 months). During follow-up, 32 relapses, 53 metastases, and 52 deaths occurred (116 patients showed at least one of the main composite outcomes). After adjusting for age, sex, sentinel lymph nodes affected at diagnosis, BMI, diabetes, nighttime with an oxygen saturation below 90%, Breslow index, Epworth sleepiness scale scores, and melanoma treatment, moderate (hazard ratio [HR], 2.45; 95% CI, 1.09-5.49) and severe OSA (HR, 2.96; 95% CI, 1.36-6.42) were associated with poorer prognosis of melanoma compared with the control group. However, good adherence to CPAP avoided this excess risk (HR, 1.66; 95% CI, 0.71-3.90).
Moderate to severe untreated OSA is an independent risk factor for poor prognosis of melanoma. Treatment with CPAP is associated with improved melanoma outcomes compared with untreated moderate to severe OSA.</abstract><cop>United States</cop><pmid>37348828</pmid><doi>10.1016/j.chest.2023.06.012</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1931-3543 |
| ispartof | Chest, 2023-12, Vol.164 (6), p.1551-1559 |
| issn | 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2829429833 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Continuous Positive Airway Pressure Female Humans Male Melanoma - complications Melanoma - therapy Middle Aged Neoplasm Recurrence, Local - epidemiology Prognosis Prospective Studies Skin Neoplasms - complications Sleep Apnea Syndromes - complications Sleep Apnea, Obstructive - complications |
| title | Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T22%3A44%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Sleep%20Apnea%20and%20Long-Term%20CPAP%20Treatment%20in%20the%20Prognosis%20of%20Patients%20With%20Melanoma:%20A%20Prospective%20Multicenter%20Study%20of%20443%20Patients&rft.jtitle=Chest&rft.au=G%C3%B3mez-Olivas,%20Jose%20Daniel&rft.date=2023-12&rft.volume=164&rft.issue=6&rft.spage=1551&rft.epage=1559&rft.pages=1551-1559&rft.eissn=1931-3543&rft_id=info:doi/10.1016/j.chest.2023.06.012&rft_dat=%3Cproquest_pubme%3E2829429833%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2829429833&rft_id=info:pmid/37348828&rfr_iscdi=true |