Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial

The omicron BA.1 bivalent booster is used globally. Previous open-label studies of the omicron BA.1 (Moderna mRNA-1273.214) booster showed superior neutralising antibody responses against omicron BA.1 and other variants compared with the original mRNA-1273 booster. We aimed to compare the safety and...

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Veröffentlicht in:	The Lancet infectious diseases 2023-09, Vol.23 (9), p.1007-1019
Hauptverfasser:	Lee, Ivan T, Cosgrove, Catherine A, Moore, Patrick, Bethune, Claire, Nally, Rhiannon, Bula, Marcin, Kalra, Philip A, Clark, Rebecca, Dargan, Paul I, Boffito, Marta, Sheridan, Ray, Moran, Ed, Darton, Thomas C, Burns, Fiona, Saralaya, Dinesh, Duncan, Christopher J A, Lillie, Patrick J, San Francisco Ramos, Alberto, Galiza, Eva P, Heath, Paul T, Girard, Bethany, Parker, Christy, Rust, Dondi, Mehta, Shraddha, de Windt, Elizabeth, Sutherland, Andrea, Tomassini, Joanne E, Dutko, Frank J, Chalkias, Spyros, Deng, Weiping, Chen, Xing, Feng, Jing, Tracy, LaRee, Zhou, Honghong, Miller, Jacqueline M, Das, Rituparna, Browne, Duncan, Chadwick, David, Cosgrove, Catherine A., Dargan, Paul I., Darton, Thomas C., Duncan, Christopher J.A., Emmett, Stevan, Galiza, Eva P., Galloway, James, Heath, Paul T., Jones, Lucy, Kalra, Philip A., Kaminski, Rachel, Lazarus, Rajeka, Lillie, Patrick J., Palfreeman, Adrian, Ramos, Alberto San Francisco, Rampling, Tommy, Sahdev, Anju, Soiza, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 Accountability Active control Antibodies Antibodies, Neutralizing Antibodies, Viral COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Humans Immune response Immunogenicity Immunogenicity, Vaccine Infectious diseases Injections mRNA Safety SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 United Kingdom Vaccine efficacy Vaccines
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