Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary

Due to the strong tendency towards poorly soluble drugs in modern development pipelines, enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals and lipid-based formulations are frequently applied to solubilize or generate supersaturation in gastrointestinal fluids...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2023-09, Vol.188, p.106505-106505, Article 106505
Hauptverfasser:	Reppas, Christos, Kuentz, Martin, Bauer-Brandl, Annette, Carlert, Sara, Dallmann, André, Dietrich, Shirin, Dressman, Jennifer, Ejskjaer, Lotte, Frechen, Sebastian, Guidetti, Matteo, Holm, René, Holzem, Florentin Lukas, Karlsson, Εva, Kostewicz, Edmund, Panbachi, Shaida, Paulus, Felix, Senniksen, Malte Bøgh, Stillhart, Cordula, Turner, David B., Vertzoni, Maria, Vrenken, Paul, Zöller, Laurin, Griffin, Brendan T., O'Dwyer, Patrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous solid dispersions Co-crystals Computational Cyclodextrins Enabling formulations In silico In vitro Lipid-based formulations PBBM rDCS Salts
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