Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study
Objective Our goal was to determine the efficacy of the American Society for Parenteral and Enteral Nutrition's recommended carnitine dosage of 5 mg/kg/day in maintaining normal serum free carnitine and total acylcarnitine levels in preterm neonates receiving parenteral nutrition (PN). Study De...
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| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 2023-08, Vol.47 (6), p.746-753 |
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| container_title | JPEN. Journal of parenteral and enteral nutrition |
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| creator | Sasenick, Jonathan Miller, Malki Rastogi, Deepa Morrissey, Mark Rastogi, Shantanu |
| description | Objective
Our goal was to determine the efficacy of the American Society for Parenteral and Enteral Nutrition's recommended carnitine dosage of 5 mg/kg/day in maintaining normal serum free carnitine and total acylcarnitine levels in preterm neonates receiving parenteral nutrition (PN).
Study Design
A retrospective cohort study was conducted on neonates born |
| doi_str_mv | 10.1002/jpen.2535 |
| format | Article |
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Our goal was to determine the efficacy of the American Society for Parenteral and Enteral Nutrition's recommended carnitine dosage of 5 mg/kg/day in maintaining normal serum free carnitine and total acylcarnitine levels in preterm neonates receiving parenteral nutrition (PN).
Study Design
A retrospective cohort study was conducted on neonates born <30 weeks gestation and weighing <1250 g, comparing those who received carnitine supplementation to those without supplementation. Free carnitine and total acylcarnitine data were collected from routine newborn screens in the first days of life and on full enetral feeds. Univariate analysis was performed, and those factors that were significantly different between the two groups were adjusted for using mixed effects analysis.
Results
There were 108 supplemented and 45 unsupplemented neonates in the study. At baseline, free carnitine (19.8 ± 3.3 vs 18.9 ± 3.7 µmol/L, P = 0.53) and total acylcarnitine (26.6 ± 5.1 vs 22.5 ± 7.1 µmol/L, P = 0.11) were similar between the two groups. At full enteral feeds, compared with unsupplemented group, supplemented infants had significantly higher free carnitine (27.1 ± 16.4 vs 17.1 ± 8.5 µmol/L, P < 0.001) and total acylcarnitine (30.3 ± 11.5 vs 20.2 ± 10.1 µmol/L, P < 0.001). None of the supplemented neonates developed biochemical carnitine deficiency as compared with 18% in the unsupplemented group (P < 0.001). No difference was observed in time to reach full lipid provision, and there were no differences in the change in the triglyceride levels from baseline to the time on full PN lipid provision (P = 0.39).
Conclusion
Preterm neonates routinely supplemented with parenteral carnitine at 5 mg/kg/day demonstrated higher free carnitine and total acylcarnitine levels at full feeds, with none developing biochemical carnitine deficiency.</description><identifier>ISSN: 0148-6071</identifier><identifier>EISSN: 1941-2444</identifier><identifier>DOI: 10.1002/jpen.2535</identifier><identifier>PMID: 37345267</identifier><language>eng</language><publisher>United States</publisher><subject>Amino Acids ; Carnitine ; Dietary Supplements ; free carnitine ; Humans ; Infant ; Infant, Newborn ; Lipids ; preterm ; Retrospective Studies ; total acylcarnitine ; triglyceride</subject><ispartof>JPEN. Journal of parenteral and enteral nutrition, 2023-08, Vol.47 (6), p.746-753</ispartof><rights>2023 American Society for Parenteral and Enteral Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3605-a0c1074e4763591ad655a7df1c75afd29542b5ae071bebcfeb4ecf4b6782ec9c3</citedby><cites>FETCH-LOGICAL-c3605-a0c1074e4763591ad655a7df1c75afd29542b5ae071bebcfeb4ecf4b6782ec9c3</cites><orcidid>0000-0002-5631-7547</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjpen.2535$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjpen.2535$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37345267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasenick, Jonathan</creatorcontrib><creatorcontrib>Miller, Malki</creatorcontrib><creatorcontrib>Rastogi, Deepa</creatorcontrib><creatorcontrib>Morrissey, Mark</creatorcontrib><creatorcontrib>Rastogi, Shantanu</creatorcontrib><title>Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study</title><title>JPEN. Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>Objective
Our goal was to determine the efficacy of the American Society for Parenteral and Enteral Nutrition's recommended carnitine dosage of 5 mg/kg/day in maintaining normal serum free carnitine and total acylcarnitine levels in preterm neonates receiving parenteral nutrition (PN).
Study Design
A retrospective cohort study was conducted on neonates born <30 weeks gestation and weighing <1250 g, comparing those who received carnitine supplementation to those without supplementation. Free carnitine and total acylcarnitine data were collected from routine newborn screens in the first days of life and on full enetral feeds. Univariate analysis was performed, and those factors that were significantly different between the two groups were adjusted for using mixed effects analysis.
Results
There were 108 supplemented and 45 unsupplemented neonates in the study. At baseline, free carnitine (19.8 ± 3.3 vs 18.9 ± 3.7 µmol/L, P = 0.53) and total acylcarnitine (26.6 ± 5.1 vs 22.5 ± 7.1 µmol/L, P = 0.11) were similar between the two groups. At full enteral feeds, compared with unsupplemented group, supplemented infants had significantly higher free carnitine (27.1 ± 16.4 vs 17.1 ± 8.5 µmol/L, P < 0.001) and total acylcarnitine (30.3 ± 11.5 vs 20.2 ± 10.1 µmol/L, P < 0.001). None of the supplemented neonates developed biochemical carnitine deficiency as compared with 18% in the unsupplemented group (P < 0.001). No difference was observed in time to reach full lipid provision, and there were no differences in the change in the triglyceride levels from baseline to the time on full PN lipid provision (P = 0.39).
Conclusion
Preterm neonates routinely supplemented with parenteral carnitine at 5 mg/kg/day demonstrated higher free carnitine and total acylcarnitine levels at full feeds, with none developing biochemical carnitine deficiency.</description><subject>Amino Acids</subject><subject>Carnitine</subject><subject>Dietary Supplements</subject><subject>free carnitine</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lipids</subject><subject>preterm</subject><subject>Retrospective Studies</subject><subject>total acylcarnitine</subject><subject>triglyceride</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOxSAQhonR6PGy8AUMS11UgULpcWdOvMaoC103lE4jpoUKVHPewweWc1FXriaZ-fJlZn6EDik5pYSws7cB7CkTudhAEzrlNGOc8000IZSXWUEk3UG7IbwRQvKCkG20k8ucC1bICfqaKW9NNBZwGIehgx5sVNE4i43VHlSAgAP4scfaWZ2GfjkN2LW49QBY_wqUbXB0UXVY6Xn31zcWDx4i-B5bcFZFCOf4AqeWd2EAHc1H0rhX5yMOcWzm-2irVV2Ag3XdQy9Xl8-zm-z-8fp2dnGf6XSHyBTRlEgOXBa5mFLVFEIo2bRUS6Hahk0FZ7VQkB5QQ61bqDnolteFLBnoqc730PHKO3j3PkKIVW-Chq5Tac8xVKxkpZQ5IWVCT1aoTjsHD201eNMrP68oqRYhVIsQqkUIiT1aa8e6h-aX_Pl6As5WwKfpYP6_qbp7unxYKr8B8o-WvQ</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Sasenick, Jonathan</creator><creator>Miller, Malki</creator><creator>Rastogi, Deepa</creator><creator>Morrissey, Mark</creator><creator>Rastogi, Shantanu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5631-7547</orcidid></search><sort><creationdate>202308</creationdate><title>Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study</title><author>Sasenick, Jonathan ; Miller, Malki ; Rastogi, Deepa ; Morrissey, Mark ; Rastogi, Shantanu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3605-a0c1074e4763591ad655a7df1c75afd29542b5ae071bebcfeb4ecf4b6782ec9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino Acids</topic><topic>Carnitine</topic><topic>Dietary Supplements</topic><topic>free carnitine</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lipids</topic><topic>preterm</topic><topic>Retrospective Studies</topic><topic>total acylcarnitine</topic><topic>triglyceride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasenick, Jonathan</creatorcontrib><creatorcontrib>Miller, Malki</creatorcontrib><creatorcontrib>Rastogi, Deepa</creatorcontrib><creatorcontrib>Morrissey, Mark</creatorcontrib><creatorcontrib>Rastogi, Shantanu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasenick, Jonathan</au><au>Miller, Malki</au><au>Rastogi, Deepa</au><au>Morrissey, Mark</au><au>Rastogi, Shantanu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>2023-08</date><risdate>2023</risdate><volume>47</volume><issue>6</issue><spage>746</spage><epage>753</epage><pages>746-753</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><abstract>Objective
Our goal was to determine the efficacy of the American Society for Parenteral and Enteral Nutrition's recommended carnitine dosage of 5 mg/kg/day in maintaining normal serum free carnitine and total acylcarnitine levels in preterm neonates receiving parenteral nutrition (PN).
Study Design
A retrospective cohort study was conducted on neonates born <30 weeks gestation and weighing <1250 g, comparing those who received carnitine supplementation to those without supplementation. Free carnitine and total acylcarnitine data were collected from routine newborn screens in the first days of life and on full enetral feeds. Univariate analysis was performed, and those factors that were significantly different between the two groups were adjusted for using mixed effects analysis.
Results
There were 108 supplemented and 45 unsupplemented neonates in the study. At baseline, free carnitine (19.8 ± 3.3 vs 18.9 ± 3.7 µmol/L, P = 0.53) and total acylcarnitine (26.6 ± 5.1 vs 22.5 ± 7.1 µmol/L, P = 0.11) were similar between the two groups. At full enteral feeds, compared with unsupplemented group, supplemented infants had significantly higher free carnitine (27.1 ± 16.4 vs 17.1 ± 8.5 µmol/L, P < 0.001) and total acylcarnitine (30.3 ± 11.5 vs 20.2 ± 10.1 µmol/L, P < 0.001). None of the supplemented neonates developed biochemical carnitine deficiency as compared with 18% in the unsupplemented group (P < 0.001). No difference was observed in time to reach full lipid provision, and there were no differences in the change in the triglyceride levels from baseline to the time on full PN lipid provision (P = 0.39).
Conclusion
Preterm neonates routinely supplemented with parenteral carnitine at 5 mg/kg/day demonstrated higher free carnitine and total acylcarnitine levels at full feeds, with none developing biochemical carnitine deficiency.</abstract><cop>United States</cop><pmid>37345267</pmid><doi>10.1002/jpen.2535</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5631-7547</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acids Carnitine Dietary Supplements free carnitine Humans Infant Infant, Newborn Lipids preterm Retrospective Studies total acylcarnitine triglyceride |
| title | Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: A retrospective cohort study |
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