Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models
The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the muco...
Gespeichert in:
| Veröffentlicht in: | Biomaterials 2004-07, Vol.25 (15), p.3041-3048 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3048 |
|---|---|
| container_issue | 15 |
| container_start_page | 3041 |
| container_title | Biomaterials |
| container_volume | 25 |
| creator | Adikwu, Michael U. Yoshikawa, Yukako Takada, Kanji |
| description | The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125.6 and 135.6
mg
h/ml at 200 and 400
mg/kg BW, respectively. For the mucoadhesive products using the same dose levels, the AUCs were modified to 102.4 and 150.2 in detarium gum and 59.9 and 80.4 in NaCMC. The results indicate that detarium gum is a good excipient for the formulation of metformin mucoadhesive delivery systems when compared with NaCMC. The gum also showed promising antidiabetic effect and should be cautiously used as it may lead to depressed blood-glucose levels beyond the desired levels. |
| doi_str_mv | 10.1016/j.biomaterials.2003.09.073 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_28286265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961203008111</els_id><sourcerecordid>28286265</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-402f095505bb51db7a23b863823ed890fe847083a74baf4437deb76d1615c5093</originalsourceid><addsrcrecordid>eNqNkU2O1DAQhSMEYpqBKyCLBbs0_okThx0afqWRYAFry7Er6mriONjOoGbFHbgRR-EkuNXNzw5Wlkvfe1V6r6oeMbpllLVP9tsBgzcZIpopbTmlYkv7Le3ErWrDVKdq2VN5u9pQ1vC6bxm_qO6ltKflTxt-t7pgTd92UnSb6vu7nYne2OAOs_Fof3z9tpwnH3GGjJYsMYw4QSJhJB7yGKLHmewOLga7m0JEB2SMwRND_GqDcTtIeFNmBVwnkzHMR6khS5gOyVhb_I-az5h3xMwZHZrh16YFYj6Q4p9yhCWHLyEHi3ONs1stOPKbjSYTHxxM6X51Zyw5wIPze1l9ePni_dXr-vrtqzdXz65r2wiV64bykfZSUjkMkrmhM1wMqhWKC3CqpyOopqNKmK4ZzNg0onMwdK1jLZNW0l5cVo9PvuXMTyukrD0mC9NkZghr0lxx1fJW_hNkneJS9LyAT0-gjSGlCKNeInoTD5pRfaxa7_XfVetj1Zr2ulRdxA_PW9bBg_sjPXdbgOcnoGQENwhRJ4swlxQxgs3aBfyfPT8Bhn7Jbg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17825392</pqid></control><display><type>article</type><title>Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Adikwu, Michael U. ; Yoshikawa, Yukako ; Takada, Kanji</creator><creatorcontrib>Adikwu, Michael U. ; Yoshikawa, Yukako ; Takada, Kanji</creatorcontrib><description>The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125.6 and 135.6
mg
h/ml at 200 and 400
mg/kg BW, respectively. For the mucoadhesive products using the same dose levels, the AUCs were modified to 102.4 and 150.2 in detarium gum and 59.9 and 80.4 in NaCMC. The results indicate that detarium gum is a good excipient for the formulation of metformin mucoadhesive delivery systems when compared with NaCMC. The gum also showed promising antidiabetic effect and should be cautiously used as it may lead to depressed blood-glucose levels beyond the desired levels.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2003.09.073</identifier><identifier>PMID: 14967537</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adhesiveness ; Animals ; Blood Glucose - analysis ; Chemistry, Pharmaceutical - methods ; Culture Techniques ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Drug Compounding - methods ; Drug Delivery Systems - methods ; Excipients - pharmacokinetics ; Excipients - pharmacology ; Galactose - administration & dosage ; Galactose - pharmacokinetics ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - blood ; Hypoglycemic Agents - pharmacokinetics ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - physiology ; Male ; Metformin - administration & dosage ; Metformin - blood ; Metformin - pharmacokinetics ; Metformin HCl ; Mucoadhesive formulation ; Pharmacodynamic–pharmacokinetic profile ; Plant Gums ; Polysaccharide ; Rats ; Rats, Wistar ; Streptozocin ; Tensile Strength - drug effects ; Tissue Adhesives - pharmacokinetics ; Tissue Adhesives - pharmacology ; Treatment Outcome</subject><ispartof>Biomaterials, 2004-07, Vol.25 (15), p.3041-3048</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-402f095505bb51db7a23b863823ed890fe847083a74baf4437deb76d1615c5093</citedby><cites>FETCH-LOGICAL-c438t-402f095505bb51db7a23b863823ed890fe847083a74baf4437deb76d1615c5093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2003.09.073$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14967537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adikwu, Michael U.</creatorcontrib><creatorcontrib>Yoshikawa, Yukako</creatorcontrib><creatorcontrib>Takada, Kanji</creatorcontrib><title>Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125.6 and 135.6
mg
h/ml at 200 and 400
mg/kg BW, respectively. For the mucoadhesive products using the same dose levels, the AUCs were modified to 102.4 and 150.2 in detarium gum and 59.9 and 80.4 in NaCMC. The results indicate that detarium gum is a good excipient for the formulation of metformin mucoadhesive delivery systems when compared with NaCMC. The gum also showed promising antidiabetic effect and should be cautiously used as it may lead to depressed blood-glucose levels beyond the desired levels.</description><subject>Adhesiveness</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Culture Techniques</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Drug Compounding - methods</subject><subject>Drug Delivery Systems - methods</subject><subject>Excipients - pharmacokinetics</subject><subject>Excipients - pharmacology</subject><subject>Galactose - administration & dosage</subject><subject>Galactose - pharmacokinetics</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - blood</subject><subject>Hypoglycemic Agents - pharmacokinetics</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - physiology</subject><subject>Male</subject><subject>Metformin - administration & dosage</subject><subject>Metformin - blood</subject><subject>Metformin - pharmacokinetics</subject><subject>Metformin HCl</subject><subject>Mucoadhesive formulation</subject><subject>Pharmacodynamic–pharmacokinetic profile</subject><subject>Plant Gums</subject><subject>Polysaccharide</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><subject>Tensile Strength - drug effects</subject><subject>Tissue Adhesives - pharmacokinetics</subject><subject>Tissue Adhesives - pharmacology</subject><subject>Treatment Outcome</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2O1DAQhSMEYpqBKyCLBbs0_okThx0afqWRYAFry7Er6mriONjOoGbFHbgRR-EkuNXNzw5Wlkvfe1V6r6oeMbpllLVP9tsBgzcZIpopbTmlYkv7Le3ErWrDVKdq2VN5u9pQ1vC6bxm_qO6ltKflTxt-t7pgTd92UnSb6vu7nYne2OAOs_Fof3z9tpwnH3GGjJYsMYw4QSJhJB7yGKLHmewOLga7m0JEB2SMwRND_GqDcTtIeFNmBVwnkzHMR6khS5gOyVhb_I-az5h3xMwZHZrh16YFYj6Q4p9yhCWHLyEHi3ONs1stOPKbjSYTHxxM6X51Zyw5wIPze1l9ePni_dXr-vrtqzdXz65r2wiV64bykfZSUjkMkrmhM1wMqhWKC3CqpyOopqNKmK4ZzNg0onMwdK1jLZNW0l5cVo9PvuXMTyukrD0mC9NkZghr0lxx1fJW_hNkneJS9LyAT0-gjSGlCKNeInoTD5pRfaxa7_XfVetj1Zr2ulRdxA_PW9bBg_sjPXdbgOcnoGQENwhRJ4swlxQxgs3aBfyfPT8Bhn7Jbg</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Adikwu, Michael U.</creator><creator>Yoshikawa, Yukako</creator><creator>Takada, Kanji</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>F28</scope></search><sort><creationdate>20040701</creationdate><title>Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models</title><author>Adikwu, Michael U. ; Yoshikawa, Yukako ; Takada, Kanji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-402f095505bb51db7a23b863823ed890fe847083a74baf4437deb76d1615c5093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adhesiveness</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Culture Techniques</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Drug Compounding - methods</topic><topic>Drug Delivery Systems - methods</topic><topic>Excipients - pharmacokinetics</topic><topic>Excipients - pharmacology</topic><topic>Galactose - administration & dosage</topic><topic>Galactose - pharmacokinetics</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - blood</topic><topic>Hypoglycemic Agents - pharmacokinetics</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - physiology</topic><topic>Male</topic><topic>Metformin - administration & dosage</topic><topic>Metformin - blood</topic><topic>Metformin - pharmacokinetics</topic><topic>Metformin HCl</topic><topic>Mucoadhesive formulation</topic><topic>Pharmacodynamic–pharmacokinetic profile</topic><topic>Plant Gums</topic><topic>Polysaccharide</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><topic>Tensile Strength - drug effects</topic><topic>Tissue Adhesives - pharmacokinetics</topic><topic>Tissue Adhesives - pharmacology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adikwu, Michael U.</creatorcontrib><creatorcontrib>Yoshikawa, Yukako</creatorcontrib><creatorcontrib>Takada, Kanji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adikwu, Michael U.</au><au>Yoshikawa, Yukako</au><au>Takada, Kanji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>25</volume><issue>15</issue><spage>3041</spage><epage>3048</epage><pages>3041-3048</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125.6 and 135.6
mg
h/ml at 200 and 400
mg/kg BW, respectively. For the mucoadhesive products using the same dose levels, the AUCs were modified to 102.4 and 150.2 in detarium gum and 59.9 and 80.4 in NaCMC. The results indicate that detarium gum is a good excipient for the formulation of metformin mucoadhesive delivery systems when compared with NaCMC. The gum also showed promising antidiabetic effect and should be cautiously used as it may lead to depressed blood-glucose levels beyond the desired levels.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>14967537</pmid><doi>10.1016/j.biomaterials.2003.09.073</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2004-07, Vol.25 (15), p.3041-3048 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_28286265 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adhesiveness Animals Blood Glucose - analysis Chemistry, Pharmaceutical - methods Culture Techniques Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Drug Compounding - methods Drug Delivery Systems - methods Excipients - pharmacokinetics Excipients - pharmacology Galactose - administration & dosage Galactose - pharmacokinetics Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Intestinal Mucosa - drug effects Intestinal Mucosa - physiology Male Metformin - administration & dosage Metformin - blood Metformin - pharmacokinetics Metformin HCl Mucoadhesive formulation Pharmacodynamic–pharmacokinetic profile Plant Gums Polysaccharide Rats Rats, Wistar Streptozocin Tensile Strength - drug effects Tissue Adhesives - pharmacokinetics Tissue Adhesives - pharmacology Treatment Outcome |
| title | Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A50%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacodynamic%E2%80%93pharmacokinetic%20profiles%20of%20metformin%20hydrochloride%20from%20a%20mucoadhesive%20formulation%20of%20a%20polysaccharide%20with%20antidiabetic%20property%20in%20streptozotocin-induced%20diabetic%20rat%20models&rft.jtitle=Biomaterials&rft.au=Adikwu,%20Michael%20U.&rft.date=2004-07-01&rft.volume=25&rft.issue=15&rft.spage=3041&rft.epage=3048&rft.pages=3041-3048&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/j.biomaterials.2003.09.073&rft_dat=%3Cproquest_cross%3E28286265%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17825392&rft_id=info:pmid/14967537&rft_els_id=S0142961203008111&rfr_iscdi=true |