Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc

Intracellular Delivery of an Antibody-Like Molecule Capable of Inhibiting c-Myc

A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize in...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2023-04, Vol.509 (1), p.70-72
Hauptverfasser: Lupanova, T. N., Ulasov, A. V., Khramtsov, Y. V., Rozenkranz, A. A., Georgiev, G. P., Sobolev, A. S.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
c-Myc protein
Life Sciences
Molecular Biology
Myc protein
Nanobodies
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Beschreibung
Zusammenfassung:A modular nanotransporter (MNT) carrying the sequence of an antibody-like molecule, anti-c-Myc nanobody, was synthesized and characterized. It was demonstrated that the created MNT is able to interact with the target protein, c-Myc oncogene, with a dissociation constant of 46 ± 14 nM, internalize into target cells, change Myc-dependent expression, and exert an antiproliferative effect.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672923700114