Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis

Platelets and low-density neutrophils (LDNs) are major players in the immunopathogenesis of SLE. Despite evidence showing the importance of platelet-neutrophil complexes (PNCs) in inflammation, little is known about the relationship between LDNs and platelets in SLE. We sought to characterize the ro...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2024-02, Vol.63 (2), p.551-562
Hauptverfasser:	Tay, Sen Hee, Zharkova, Olga, Lee, Hui Yin, Toh, Michelle Min Xuan, Libau, Eshele Anak, Celhar, Teja, Narayanan, Sriram, Ahl, Patricia Jennifer, Ong, Wei Yee, Joseph, Craig, Lim, Jeffrey Chun Tatt, Wang, Lingzhi, Larbi, Anis, Liang, Shen, Lateef, Aisha, Akira, Shizuo, Ling, Lieng Hsi, Thamboo, Thomas Paulraj, Yeong, Joe Poh Seng, Lee, Bernett Teck Kwong, Edwards, Steven W, Wright, Helen L, MacAry, Paul Anthony, Connolly, John E, Fairhurst, Anna-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Leukocytes, Mononuclear Lupus Nephritis - pathology Mice Neutrophils - metabolism RNA, Messenger - metabolism Toll-Like Receptor 7 - genetics
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