ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation

•Metzincins display both pro- and anti-invasive effects in breast cancer.•Loss of myoepithelial ADAMTS3 expression drives invasion.•Degradomic analysis implicates fibronectin as a novel ADAMTS3 substrate.•ADAMTS3 restricts cell invasion through fibronectin degradation and reduced integrin α5β1 signa...

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Veröffentlicht in:	Matrix biology 2023-08, Vol.121, p.74-89
Hauptverfasser:	Gibson, Shayin V., Madzharova, Elizabeta, Tan, Amandine C., Allen, Michael D., Keller, Ulrich auf dem, Louise Jones, J., Carter, Edward P., Grose, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D models ADAMTS Breast Breast cancer Breast Neoplasms - metabolism Cell Line, Tumor Female Fibronectin Fibronectins - genetics Fibronectins - metabolism Humans Invasion Myoepithelial cell Peptide Hydrolases - metabolism Proteases Tumor Microenvironment
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