Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the Stephania genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infection...
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| creator | Shi, Liangliang Wang, Shuaizhe Zhang, Shangzu Wang, Jiawei Chen, Yaping Li, Yangyang Liu, Zhiwei Zhao, Sichen Wei, Benjun Zhang, Liying |
| description | Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the
Stephania
genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infections, cancer, and immune disorders and has great clinical translational value. However, there is no detailed research on its specific mechanism and dosage and administration methods, especially clinical research is limited. In recent years, CEP has shown significant effects in the prevention and treatment of COVID-19, suggesting its potential medicinal value waiting to be discovered. In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.
Graphical Abstract |
| doi_str_mv | 10.1007/s00210-023-02537-y |
| format | Article |
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Stephania
genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infections, cancer, and immune disorders and has great clinical translational value. However, there is no detailed research on its specific mechanism and dosage and administration methods, especially clinical research is limited. In recent years, CEP has shown significant effects in the prevention and treatment of COVID-19, suggesting its potential medicinal value waiting to be discovered. In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.
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Stephania
genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infections, cancer, and immune disorders and has great clinical translational value. However, there is no detailed research on its specific mechanism and dosage and administration methods, especially clinical research is limited. In recent years, CEP has shown significant effects in the prevention and treatment of COVID-19, suggesting its potential medicinal value waiting to be discovered. In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.
Graphical Abstract</description><subject>Alkaloids - pharmacology</subject><subject>Apoptosis</subject><subject>Arthritis</subject><subject>Autophagy</subject><subject>Benzylisoquinolines - pharmacology</subject><subject>Benzylisoquinolines - therapeutic use</subject><subject>Bioavailability</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bisbenzylisoquinoline</subject><subject>Chinese medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Neurosciences</subject><subject>Oxidative stress</subject><subject>Pharmacology/Toxicology</subject><subject>Review</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEtLxDAUhYMozjj6B1xIwY2bal5tmqUMvkAQRNcxSW-nHfoYk3Zg_r2Z6ajgwkW4hPPdc-89CJ0TfE0wFjceY0pwjCkLL2Ei3hygKeGMxkQSeoimQc9iQmU2QSfeLzHGKUmSYzRhgrEsEckUfbyCB-1sGa1ct3DgfdS10arUrtG2q7tFZXUdQVGA7X2k2zxqwJa6rXwTyCKysGV125dVCzu9ClwOrlrrvlqDP0VHha49nO3rDL3f373NH-Pnl4en-e1zbBlN-5hzmdNEgjTE8PARFgzhnHJu8iwxVlAutbQM25ynhuQyC1xmcimI5cIaNkNXo2-443MA36um8hbqWrfQDV7RjApJSZqygF7-QZfd4NqwXaBEkrIwjAaKjpR1nfcOCrVyVaPdRhGstvmrMX8V8le7_NUmNF3srQfTQP7T8h14ANgI-CC1C3C_s_-x_QLMrJFb</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Shi, Liangliang</creator><creator>Wang, Shuaizhe</creator><creator>Zhang, Shangzu</creator><creator>Wang, Jiawei</creator><creator>Chen, Yaping</creator><creator>Li, Yangyang</creator><creator>Liu, Zhiwei</creator><creator>Zhao, Sichen</creator><creator>Wei, Benjun</creator><creator>Zhang, Liying</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20231101</creationdate><title>Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives</title><author>Shi, Liangliang ; Wang, Shuaizhe ; Zhang, Shangzu ; Wang, Jiawei ; Chen, Yaping ; Li, Yangyang ; Liu, Zhiwei ; Zhao, Sichen ; Wei, Benjun ; Zhang, Liying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-449d259e9b1b44497ceb144244bd85bc7249a9c30cd46b1d981b48bd971c47cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alkaloids - pharmacology</topic><topic>Apoptosis</topic><topic>Arthritis</topic><topic>Autophagy</topic><topic>Benzylisoquinolines - pharmacology</topic><topic>Benzylisoquinolines - therapeutic use</topic><topic>Bioavailability</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bisbenzylisoquinoline</topic><topic>Chinese medicine</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Neurosciences</topic><topic>Oxidative stress</topic><topic>Pharmacology/Toxicology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Liangliang</creatorcontrib><creatorcontrib>Wang, Shuaizhe</creatorcontrib><creatorcontrib>Zhang, Shangzu</creatorcontrib><creatorcontrib>Wang, Jiawei</creatorcontrib><creatorcontrib>Chen, Yaping</creatorcontrib><creatorcontrib>Li, Yangyang</creatorcontrib><creatorcontrib>Liu, Zhiwei</creatorcontrib><creatorcontrib>Zhao, Sichen</creatorcontrib><creatorcontrib>Wei, Benjun</creatorcontrib><creatorcontrib>Zhang, Liying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Liangliang</au><au>Wang, Shuaizhe</au><au>Zhang, Shangzu</au><au>Wang, Jiawei</au><au>Chen, Yaping</au><au>Li, Yangyang</au><au>Liu, Zhiwei</au><au>Zhao, Sichen</au><au>Wei, Benjun</au><au>Zhang, Liying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>396</volume><issue>11</issue><spage>2843</spage><epage>2860</epage><pages>2843-2860</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the
Stephania
genus, which has biological functions such as regulating autophagy, inhibiting inflammation, oxidative stress, and apoptosis. It is often used for the treatment of inflammatory diseases, viral infections, cancer, and immune disorders and has great clinical translational value. However, there is no detailed research on its specific mechanism and dosage and administration methods, especially clinical research is limited. In recent years, CEP has shown significant effects in the prevention and treatment of COVID-19, suggesting its potential medicinal value waiting to be discovered. In this article, we comprehensively introduce the molecular structure of CEP and its derivatives, describe in detail the pharmacological mechanisms of CEP in various diseases, and discuss how to chemically modify and design CEP to improve its bioavailability. In summary, this work will provide a reference for further research and clinical application of CEP.
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| subjects | Alkaloids - pharmacology Apoptosis Arthritis Autophagy Benzylisoquinolines - pharmacology Benzylisoquinolines - therapeutic use Bioavailability Biomedical and Life Sciences Biomedicine Bisbenzylisoquinoline Chinese medicine Coronaviruses COVID-19 Humans Inflammatory diseases Neurosciences Oxidative stress Pharmacology/Toxicology Review |
| title | Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives |
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