c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation

The limited efficacy of chimeric antigen receptor (CAR) T cell therapy for solid tumors necessitates engineering strategies that promote functional persistence in an immunosuppressive environment. Herein, we use c-Kit signaling, a physiological pathway associated with stemness in hematopoietic proge...

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Veröffentlicht in:	Nature cancer 2023-07, Vol.4 (7), p.1001-1015
Hauptverfasser:	Xiong, Yuquan, Taleb, Meriem, Misawa, Kyohei, Hou, Zhaohua, Banerjee, Srijita, Amador-Molina, Alfredo, Jones, David R, Chintala, Navin K, Adusumilli, Prasad S
Format:	Artikel
Sprache:	eng
Schlagworte:	CD28 Antigens - genetics CD28 Antigens - metabolism Cell Line, Tumor Immunotherapy, Adoptive Interleukin-2 - metabolism Interleukin-2 - pharmacology Proto-Oncogene Proteins c-kit - metabolism Receptor Protein-Tyrosine Kinases T-Lymphocytes
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