Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis
Background Carotid stenosis, even in the clinically asymptomatic stage, causes cognitive impairment, silent lesions, and hemispheric changes. The corpus callosum (CC) is crucial for hemispheric cortical integration and specialization. Purpose To examine if CC morphology and connectivity relate to co...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2024-03, Vol.59 (3), p.998-1007 |
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| creator | Liu, Xitong Xu, Dan Zhong, Xiaoli Ren, Jinxia Wang, Huan Yu, Minhua Gao, Lei Xu, Haibo |
| description | Background
Carotid stenosis, even in the clinically asymptomatic stage, causes cognitive impairment, silent lesions, and hemispheric changes. The corpus callosum (CC) is crucial for hemispheric cortical integration and specialization.
Purpose
To examine if CC morphology and connectivity relate to cognitive decline and lesion burden in asymptomatic carotid stenosis (ACS).
Study Type
Retrospective, cross‐sectional.
Population
33 patients with unilaterally severe (70%) ACS and 28 demographically and comorbidity‐matched controls. A publicly available healthy adult lifespan (ages between 18 and 80; n = 483) MRI dataset was also included.
Field Strength/Sequence
A 3.0 T; T1 MPRAGE and diffusion weighted gradient echo‐planar imaging sequences.
Assessment
Structural MRI and multidomain cognitive data were obtained. Midsagittal CC area, circularity, thickness, integrity, and probabilistic tractography were calculated and correlated with cognitive tests and white matter hyperintensity. Fractional anisotropy, mean diffusivity (MD), and radial diffusivity were determined from DTI.
Statistical Tests
Independent two‐sample t‐tests, χ2 tests, Mann–Whitney U, locally weighted scatterplot smoothing (LOWESS) curve fit, and Pearson correlation. A P value < 0.05 was considered statistically significant.
Results
Patients with ACS demonstrated significant reductions in callosal area, circularity, and thickness compared to controls. The callosal atrophy was significantly correlated with white matter hyperintensity size (r = −0.629, P |
| doi_str_mv | 10.1002/jmri.28872 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2827920319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2827920319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4112-a7d6eba19e1f8a81567b4351bda01b7b3d6b8516ee0e952f471ec1ddd24ae2af3</originalsourceid><addsrcrecordid>eNp9kMtKxDAUQIMovjd-gBTciFDNTZs2WQ6DTxwEH-uQNreaIW3GpKP0762OunDhKpdw7uFyCDkAegqUsrN5G-wpE6Jka2QbOGMp46JYH2fKsxQELbfIToxzSqmUOd8kW1mZZbmkYpvMJq7HgCaZaud81C6Z-bB48c4_D4nuxn_fdVj39s32Q2K7ZBKHdtH7Vve2HpeC761JHnrsfLRxj2w02kXc_353ydPF-eP0Kr29u7yeTm7TOgdgqS5NgZUGidAILYAXZZVnHCqjKVRllZmiEhwKRIqSsyYvAWswxrBcI9NNtkuOV95F8K9LjL1qbazROd2hX0bFBCsloxnIET36g879MnTjdYpJxgTnIPlInayoOvgYAzZqEWyrw6CAqs_I6jOy-oo8woffymXVovlFf6qOAKyAd-tw-Eelbmb31yvpB2r7h4I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2922855195</pqid></control><display><type>article</type><title>Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Liu, Xitong ; Xu, Dan ; Zhong, Xiaoli ; Ren, Jinxia ; Wang, Huan ; Yu, Minhua ; Gao, Lei ; Xu, Haibo</creator><creatorcontrib>Liu, Xitong ; Xu, Dan ; Zhong, Xiaoli ; Ren, Jinxia ; Wang, Huan ; Yu, Minhua ; Gao, Lei ; Xu, Haibo</creatorcontrib><description>Background
Carotid stenosis, even in the clinically asymptomatic stage, causes cognitive impairment, silent lesions, and hemispheric changes. The corpus callosum (CC) is crucial for hemispheric cortical integration and specialization.
Purpose
To examine if CC morphology and connectivity relate to cognitive decline and lesion burden in asymptomatic carotid stenosis (ACS).
Study Type
Retrospective, cross‐sectional.
Population
33 patients with unilaterally severe (70%) ACS and 28 demographically and comorbidity‐matched controls. A publicly available healthy adult lifespan (ages between 18 and 80; n = 483) MRI dataset was also included.
Field Strength/Sequence
A 3.0 T; T1 MPRAGE and diffusion weighted gradient echo‐planar imaging sequences.
Assessment
Structural MRI and multidomain cognitive data were obtained. Midsagittal CC area, circularity, thickness, integrity, and probabilistic tractography were calculated and correlated with cognitive tests and white matter hyperintensity. Fractional anisotropy, mean diffusivity (MD), and radial diffusivity were determined from DTI.
Statistical Tests
Independent two‐sample t‐tests, χ2 tests, Mann–Whitney U, locally weighted scatterplot smoothing (LOWESS) curve fit, and Pearson correlation. A P value < 0.05 was considered statistically significant.
Results
Patients with ACS demonstrated significant reductions in callosal area, circularity, and thickness compared to controls. The callosal atrophy was significantly correlated with white matter hyperintensity size (r = −0.629, P < 0.001). Voxel‐wise analysis of diffusion measures in the volumetric CC showed that ACS patients exhibited significantly lower fractional anisotropy and higher MD and radial diffusivity in the genu and splenium of the CC than controls. Further lifespan trajectory analysis showed that although the midsagittal callosal area, circularity, and thickness exhibited age‐related decreases, the values in the ACS patients were significantly lower in all age groups.
Data Conclusion
Midsagittal callosal atrophy and connectivity reflect the load of silent lesions and the severity of cognitive decline, respectively, suggesting that CC degeneration has potential to serve as an early marker in ACS.
Level of Evidence
3
Technical Efficacy Stage
2</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.28872</identifier><identifier>PMID: 37334908</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Anisotropy ; Asymptomatic ; Atrophy ; Circularity ; Cognitive ability ; Comorbidity ; Corpus callosum ; Correlation ; Degeneration ; Diffusivity ; Field strength ; hemispheric asymmetry ; interhemispheric connectivity ; Lesions ; Life span ; Magnetic resonance imaging ; Morphology ; silent infarcts ; Statistical analysis ; Statistical tests ; Stenosis ; Substantia alba ; Thickness ; Trajectory analysis ; Trajectory control ; vascular cognitive impairment</subject><ispartof>Journal of magnetic resonance imaging, 2024-03, Vol.59 (3), p.998-1007</ispartof><rights>2023 International Society for Magnetic Resonance in Medicine.</rights><rights>2024 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4112-a7d6eba19e1f8a81567b4351bda01b7b3d6b8516ee0e952f471ec1ddd24ae2af3</citedby><cites>FETCH-LOGICAL-c4112-a7d6eba19e1f8a81567b4351bda01b7b3d6b8516ee0e952f471ec1ddd24ae2af3</cites><orcidid>0000-0002-0081-0172 ; 0000-0002-8451-8979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.28872$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.28872$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37334908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xitong</creatorcontrib><creatorcontrib>Xu, Dan</creatorcontrib><creatorcontrib>Zhong, Xiaoli</creatorcontrib><creatorcontrib>Ren, Jinxia</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Yu, Minhua</creatorcontrib><creatorcontrib>Gao, Lei</creatorcontrib><creatorcontrib>Xu, Haibo</creatorcontrib><title>Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Carotid stenosis, even in the clinically asymptomatic stage, causes cognitive impairment, silent lesions, and hemispheric changes. The corpus callosum (CC) is crucial for hemispheric cortical integration and specialization.
Purpose
To examine if CC morphology and connectivity relate to cognitive decline and lesion burden in asymptomatic carotid stenosis (ACS).
Study Type
Retrospective, cross‐sectional.
Population
33 patients with unilaterally severe (70%) ACS and 28 demographically and comorbidity‐matched controls. A publicly available healthy adult lifespan (ages between 18 and 80; n = 483) MRI dataset was also included.
Field Strength/Sequence
A 3.0 T; T1 MPRAGE and diffusion weighted gradient echo‐planar imaging sequences.
Assessment
Structural MRI and multidomain cognitive data were obtained. Midsagittal CC area, circularity, thickness, integrity, and probabilistic tractography were calculated and correlated with cognitive tests and white matter hyperintensity. Fractional anisotropy, mean diffusivity (MD), and radial diffusivity were determined from DTI.
Statistical Tests
Independent two‐sample t‐tests, χ2 tests, Mann–Whitney U, locally weighted scatterplot smoothing (LOWESS) curve fit, and Pearson correlation. A P value < 0.05 was considered statistically significant.
Results
Patients with ACS demonstrated significant reductions in callosal area, circularity, and thickness compared to controls. The callosal atrophy was significantly correlated with white matter hyperintensity size (r = −0.629, P < 0.001). Voxel‐wise analysis of diffusion measures in the volumetric CC showed that ACS patients exhibited significantly lower fractional anisotropy and higher MD and radial diffusivity in the genu and splenium of the CC than controls. Further lifespan trajectory analysis showed that although the midsagittal callosal area, circularity, and thickness exhibited age‐related decreases, the values in the ACS patients were significantly lower in all age groups.
Data Conclusion
Midsagittal callosal atrophy and connectivity reflect the load of silent lesions and the severity of cognitive decline, respectively, suggesting that CC degeneration has potential to serve as an early marker in ACS.
Level of Evidence
3
Technical Efficacy Stage
2</description><subject>Anisotropy</subject><subject>Asymptomatic</subject><subject>Atrophy</subject><subject>Circularity</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Corpus callosum</subject><subject>Correlation</subject><subject>Degeneration</subject><subject>Diffusivity</subject><subject>Field strength</subject><subject>hemispheric asymmetry</subject><subject>interhemispheric connectivity</subject><subject>Lesions</subject><subject>Life span</subject><subject>Magnetic resonance imaging</subject><subject>Morphology</subject><subject>silent infarcts</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Stenosis</subject><subject>Substantia alba</subject><subject>Thickness</subject><subject>Trajectory analysis</subject><subject>Trajectory control</subject><subject>vascular cognitive impairment</subject><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUQIMovjd-gBTciFDNTZs2WQ6DTxwEH-uQNreaIW3GpKP0762OunDhKpdw7uFyCDkAegqUsrN5G-wpE6Jka2QbOGMp46JYH2fKsxQELbfIToxzSqmUOd8kW1mZZbmkYpvMJq7HgCaZaud81C6Z-bB48c4_D4nuxn_fdVj39s32Q2K7ZBKHdtH7Vve2HpeC761JHnrsfLRxj2w02kXc_353ydPF-eP0Kr29u7yeTm7TOgdgqS5NgZUGidAILYAXZZVnHCqjKVRllZmiEhwKRIqSsyYvAWswxrBcI9NNtkuOV95F8K9LjL1qbazROd2hX0bFBCsloxnIET36g879MnTjdYpJxgTnIPlInayoOvgYAzZqEWyrw6CAqs_I6jOy-oo8woffymXVovlFf6qOAKyAd-tw-Eelbmb31yvpB2r7h4I</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Liu, Xitong</creator><creator>Xu, Dan</creator><creator>Zhong, Xiaoli</creator><creator>Ren, Jinxia</creator><creator>Wang, Huan</creator><creator>Yu, Minhua</creator><creator>Gao, Lei</creator><creator>Xu, Haibo</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0081-0172</orcidid><orcidid>https://orcid.org/0000-0002-8451-8979</orcidid></search><sort><creationdate>202403</creationdate><title>Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis</title><author>Liu, Xitong ; Xu, Dan ; Zhong, Xiaoli ; Ren, Jinxia ; Wang, Huan ; Yu, Minhua ; Gao, Lei ; Xu, Haibo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4112-a7d6eba19e1f8a81567b4351bda01b7b3d6b8516ee0e952f471ec1ddd24ae2af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anisotropy</topic><topic>Asymptomatic</topic><topic>Atrophy</topic><topic>Circularity</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Corpus callosum</topic><topic>Correlation</topic><topic>Degeneration</topic><topic>Diffusivity</topic><topic>Field strength</topic><topic>hemispheric asymmetry</topic><topic>interhemispheric connectivity</topic><topic>Lesions</topic><topic>Life span</topic><topic>Magnetic resonance imaging</topic><topic>Morphology</topic><topic>silent infarcts</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Stenosis</topic><topic>Substantia alba</topic><topic>Thickness</topic><topic>Trajectory analysis</topic><topic>Trajectory control</topic><topic>vascular cognitive impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xitong</creatorcontrib><creatorcontrib>Xu, Dan</creatorcontrib><creatorcontrib>Zhong, Xiaoli</creatorcontrib><creatorcontrib>Ren, Jinxia</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Yu, Minhua</creatorcontrib><creatorcontrib>Gao, Lei</creatorcontrib><creatorcontrib>Xu, Haibo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xitong</au><au>Xu, Dan</au><au>Zhong, Xiaoli</au><au>Ren, Jinxia</au><au>Wang, Huan</au><au>Yu, Minhua</au><au>Gao, Lei</au><au>Xu, Haibo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-03</date><risdate>2024</risdate><volume>59</volume><issue>3</issue><spage>998</spage><epage>1007</epage><pages>998-1007</pages><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Background
Carotid stenosis, even in the clinically asymptomatic stage, causes cognitive impairment, silent lesions, and hemispheric changes. The corpus callosum (CC) is crucial for hemispheric cortical integration and specialization.
Purpose
To examine if CC morphology and connectivity relate to cognitive decline and lesion burden in asymptomatic carotid stenosis (ACS).
Study Type
Retrospective, cross‐sectional.
Population
33 patients with unilaterally severe (70%) ACS and 28 demographically and comorbidity‐matched controls. A publicly available healthy adult lifespan (ages between 18 and 80; n = 483) MRI dataset was also included.
Field Strength/Sequence
A 3.0 T; T1 MPRAGE and diffusion weighted gradient echo‐planar imaging sequences.
Assessment
Structural MRI and multidomain cognitive data were obtained. Midsagittal CC area, circularity, thickness, integrity, and probabilistic tractography were calculated and correlated with cognitive tests and white matter hyperintensity. Fractional anisotropy, mean diffusivity (MD), and radial diffusivity were determined from DTI.
Statistical Tests
Independent two‐sample t‐tests, χ2 tests, Mann–Whitney U, locally weighted scatterplot smoothing (LOWESS) curve fit, and Pearson correlation. A P value < 0.05 was considered statistically significant.
Results
Patients with ACS demonstrated significant reductions in callosal area, circularity, and thickness compared to controls. The callosal atrophy was significantly correlated with white matter hyperintensity size (r = −0.629, P < 0.001). Voxel‐wise analysis of diffusion measures in the volumetric CC showed that ACS patients exhibited significantly lower fractional anisotropy and higher MD and radial diffusivity in the genu and splenium of the CC than controls. Further lifespan trajectory analysis showed that although the midsagittal callosal area, circularity, and thickness exhibited age‐related decreases, the values in the ACS patients were significantly lower in all age groups.
Data Conclusion
Midsagittal callosal atrophy and connectivity reflect the load of silent lesions and the severity of cognitive decline, respectively, suggesting that CC degeneration has potential to serve as an early marker in ACS.
Level of Evidence
3
Technical Efficacy Stage
2</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37334908</pmid><doi>10.1002/jmri.28872</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0081-0172</orcidid><orcidid>https://orcid.org/0000-0002-8451-8979</orcidid></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2024-03, Vol.59 (3), p.998-1007 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anisotropy Asymptomatic Atrophy Circularity Cognitive ability Comorbidity Corpus callosum Correlation Degeneration Diffusivity Field strength hemispheric asymmetry interhemispheric connectivity Lesions Life span Magnetic resonance imaging Morphology silent infarcts Statistical analysis Statistical tests Stenosis Substantia alba Thickness Trajectory analysis Trajectory control vascular cognitive impairment |
| title | Altered Callosal Morphology and Connectivity in Asymptomatic Carotid Stenosis |
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