Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice
The effect of 5-HT 1A receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in sponta...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2023-05, Vol.175 (1), p.41-44 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kudryashov, N. V. Volkova, A. V. Shimshirt, A. A. Naplekova, P. L. Voronina, T. A. Seredenin, S. B. |
| description | The effect of 5-HT
1A
receptor agonist 8-OH-DPAT (intraperitoneal injection in doses of 1, 2, and 4 mg/kg) on spontaneous alternation behavior of mice in Y-maze was studied without and with habituation procedure and food reward. In the first case, 8-OH-DPAT administration led to a decrease in spontaneous alternation and locomotor activity in mice. At the same time, 8-OH-DPAT treatment after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, which was consistent with perseverative behavior. 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is the most suitable procedure for experimental modeling of the perseverative behavior and studying the anticompulsive activity of new substances. |
| doi_str_mv | 10.1007/s10517-023-05807-0 |
| format | Article |
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| subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Biomedical and Life Sciences Biomedicine Cell Biology Dietary restrictions Drug dosages Experiments Food Habituation Internal Medicine Laboratory Medicine Locomotor activity Medical research Mice Obsessive compulsive disorder Pathology Pathophysiology Pharmacology Reinforcement Serotonin Receptor Agonists - pharmacology Spontaneous alternation Toxicology |
| title | Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice |
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