Serum organophosphate flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones
Organophosphate flame retardants (OPFRs) are extensively used as flame retardants and plasticizers, but their endocrine disrupting potentials have raised concerns. However, the impacts of OPFR exposures on reproductive and thyroid hormones in females remains unclear. In this study, serum concentrati...
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| Veröffentlicht in: | Chemosphere (Oxford) 2023-10, Vol.337, p.139237-139237, Article 139237 |
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| creator | Liu, Yarui Li, Yongcheng Xiao, Nan Liu, Min Wang, Yu Luo, Haining Yao, Yiming Feng, Yujie Wang, Shuo |
| description | Organophosphate flame retardants (OPFRs) are extensively used as flame retardants and plasticizers, but their endocrine disrupting potentials have raised concerns. However, the impacts of OPFR exposures on reproductive and thyroid hormones in females remains unclear. In this study, serum concentrations of OPFRs were investigated, and levels of reproductive and thyroid hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, anti-Müllerian hormone, prolactin (PRL), testosterone (T), and thyroid stimulating hormone, were analyzed in childbearing-age females undergoing in-vitro fertilization treatment from Tianjin, a coastal city in China (n = 319). Tris (2-chloroethyl) phosphate (TCEP) was the predominant OPFR, with a median concentration of 0.33 ng/mL and a detection frequency of 96.6%. In the whole population, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and tris(2-chloroisopropyl) phosphate (TCIPP) were positively associated with T (p |
| doi_str_mv | 10.1016/j.chemosphere.2023.139237 |
| format | Article |
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•Serum levels of OPEs are reported in Chinese females of childbearing age.•Serum TDCIPP and TCIPP are positively associated with serum T.•Serum TEP is negatively associated with serum LH and LH/FSH.•Serum TCIPP is negatively associated with serum antral follicle counting.•Age and BMI influence the associations between serum OPEs and reproductive hormones.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2023.139237</identifier><identifier>PMID: 37331665</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Age ; Body mass index ; Female reproductive and thyroid hormones ; Organophosphate flame retardants ; Ovarian reserve ; Serum</subject><ispartof>Chemosphere (Oxford), 2023-10, Vol.337, p.139237-139237, Article 139237</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-125bd78eeda71c43bb2c1a216084a478ac652de87c66ba1c18ebf2dcd7ec9ddd3</citedby><cites>FETCH-LOGICAL-c292t-125bd78eeda71c43bb2c1a216084a478ac652de87c66ba1c18ebf2dcd7ec9ddd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2023.139237$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37331665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yarui</creatorcontrib><creatorcontrib>Li, Yongcheng</creatorcontrib><creatorcontrib>Xiao, Nan</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Luo, Haining</creatorcontrib><creatorcontrib>Yao, Yiming</creatorcontrib><creatorcontrib>Feng, Yujie</creatorcontrib><creatorcontrib>Wang, Shuo</creatorcontrib><title>Serum organophosphate flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Organophosphate flame retardants (OPFRs) are extensively used as flame retardants and plasticizers, but their endocrine disrupting potentials have raised concerns. However, the impacts of OPFR exposures on reproductive and thyroid hormones in females remains unclear. In this study, serum concentrations of OPFRs were investigated, and levels of reproductive and thyroid hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, anti-Müllerian hormone, prolactin (PRL), testosterone (T), and thyroid stimulating hormone, were analyzed in childbearing-age females undergoing in-vitro fertilization treatment from Tianjin, a coastal city in China (n = 319). Tris (2-chloroethyl) phosphate (TCEP) was the predominant OPFR, with a median concentration of 0.33 ng/mL and a detection frequency of 96.6%. In the whole population, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and tris(2-chloroisopropyl) phosphate (TCIPP) were positively associated with T (p < 0.05), while triethyl phosphate (TEP) was negatively associated with LH (p < 0.05) and LH/FSH (p < 0.01). Particularly, TCIPP was negatively associated with PRL in the younger subgroup (age≤30, p < 0.05). Moreover, TCIPP was negatively associated with diagnostic antral follicle counting (AFC) in the mediation analysis by a dominating direct effect (p < 0.01). In conclusion, serum levels of OPFRs were significantly associated with reproductive and thyroid hormone levels and a risk of decreased ovarian reserve in childbearing-age females, with age and body mass index being significant influencing factors.
[Display omitted]
•Serum levels of OPEs are reported in Chinese females of childbearing age.•Serum TDCIPP and TCIPP are positively associated with serum T.•Serum TEP is negatively associated with serum LH and LH/FSH.•Serum TCIPP is negatively associated with serum antral follicle counting.•Age and BMI influence the associations between serum OPEs and reproductive hormones.</description><subject>Age</subject><subject>Body mass index</subject><subject>Female reproductive and thyroid hormones</subject><subject>Organophosphate flame retardants</subject><subject>Ovarian reserve</subject><subject>Serum</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAURS0EokPhF5DZsZnBdhLbYVeNaEGqxAJYWy_2y8SjJA62U1S-hM_F0ymIJStvzr3XT4eQN5ztOOPy3XFnB5xCWgaMuBNMVDtetaJST8iGa9VuuWj1U7JhrG62sqmaC_IipSNjJdy0z8lFpaqKS9lsyK8vGNeJhniAOSzDqRMy0n6ECWnEDNHBnBOF2dFlhJS99T8xJupnuh_8jKnAOMGIiYae2sGPrkOIfj5QOOB7epVSsB6yDzP94fNA08NgxCUGt9rs7_ChPA_3MXhHhxCnUGpfkmc9jAlfPb6X5Nv1h6_7j9vbzzef9le3WytakculTeeURnSguK2rrhOWg-CS6RpqpcHKRjjUykrZAbdcY9cLZ51C2zrnqkvy9txb_vN9xZTN5JPFcYQZw5qM0EJJWetGFbQ9ozaGlCL2Zol-gnhvODMnMeZo_hFjTmLMWUzJvn6cWbsJ3d_kHxMF2J8BLMfeeYwmWY-zRecj2mxc8P8x8xvAxarK</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Liu, Yarui</creator><creator>Li, Yongcheng</creator><creator>Xiao, Nan</creator><creator>Liu, Min</creator><creator>Wang, Yu</creator><creator>Luo, Haining</creator><creator>Yao, Yiming</creator><creator>Feng, Yujie</creator><creator>Wang, Shuo</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202310</creationdate><title>Serum organophosphate flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones</title><author>Liu, Yarui ; Li, Yongcheng ; Xiao, Nan ; Liu, Min ; Wang, Yu ; Luo, Haining ; Yao, Yiming ; Feng, Yujie ; Wang, Shuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-125bd78eeda71c43bb2c1a216084a478ac652de87c66ba1c18ebf2dcd7ec9ddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Body mass index</topic><topic>Female reproductive and thyroid hormones</topic><topic>Organophosphate flame retardants</topic><topic>Ovarian reserve</topic><topic>Serum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yarui</creatorcontrib><creatorcontrib>Li, Yongcheng</creatorcontrib><creatorcontrib>Xiao, Nan</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Luo, Haining</creatorcontrib><creatorcontrib>Yao, Yiming</creatorcontrib><creatorcontrib>Feng, Yujie</creatorcontrib><creatorcontrib>Wang, Shuo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yarui</au><au>Li, Yongcheng</au><au>Xiao, Nan</au><au>Liu, Min</au><au>Wang, Yu</au><au>Luo, Haining</au><au>Yao, Yiming</au><au>Feng, Yujie</au><au>Wang, Shuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum organophosphate flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2023-10</date><risdate>2023</risdate><volume>337</volume><spage>139237</spage><epage>139237</epage><pages>139237-139237</pages><artnum>139237</artnum><issn>0045-6535</issn><eissn>1879-1298</eissn><abstract>Organophosphate flame retardants (OPFRs) are extensively used as flame retardants and plasticizers, but their endocrine disrupting potentials have raised concerns. However, the impacts of OPFR exposures on reproductive and thyroid hormones in females remains unclear. In this study, serum concentrations of OPFRs were investigated, and levels of reproductive and thyroid hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, anti-Müllerian hormone, prolactin (PRL), testosterone (T), and thyroid stimulating hormone, were analyzed in childbearing-age females undergoing in-vitro fertilization treatment from Tianjin, a coastal city in China (n = 319). Tris (2-chloroethyl) phosphate (TCEP) was the predominant OPFR, with a median concentration of 0.33 ng/mL and a detection frequency of 96.6%. In the whole population, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and tris(2-chloroisopropyl) phosphate (TCIPP) were positively associated with T (p < 0.05), while triethyl phosphate (TEP) was negatively associated with LH (p < 0.05) and LH/FSH (p < 0.01). Particularly, TCIPP was negatively associated with PRL in the younger subgroup (age≤30, p < 0.05). Moreover, TCIPP was negatively associated with diagnostic antral follicle counting (AFC) in the mediation analysis by a dominating direct effect (p < 0.01). In conclusion, serum levels of OPFRs were significantly associated with reproductive and thyroid hormone levels and a risk of decreased ovarian reserve in childbearing-age females, with age and body mass index being significant influencing factors.
[Display omitted]
•Serum levels of OPEs are reported in Chinese females of childbearing age.•Serum TDCIPP and TCIPP are positively associated with serum T.•Serum TEP is negatively associated with serum LH and LH/FSH.•Serum TCIPP is negatively associated with serum antral follicle counting.•Age and BMI influence the associations between serum OPEs and reproductive hormones.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37331665</pmid><doi>10.1016/j.chemosphere.2023.139237</doi><tpages>1</tpages></addata></record> |
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| subjects | Age Body mass index Female reproductive and thyroid hormones Organophosphate flame retardants Ovarian reserve Serum |
| title | Serum organophosphate flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones |
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