Loureirin B protects against cerebral ischemia/reperfusion injury through modulating M1/M2 microglial polarization via STAT6 / NF-kappaB signaling pathway

The latest research indicates that modulating microglial polarization from M1 to M2 phenotype may be a coping therapy for ischemic stroke. The present study thereby evaluated the effects of loureirin B (LB), a monomer compound extracted from Sanguis Draconis flavones (SDF), on cerebral ischemic inju...

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Veröffentlicht in:	European journal of pharmacology 2023-08, Vol.953, p.175860-175860, Article 175860
Hauptverfasser:	Li, Rui, Jia, Huiyu, Si, Min, Li, Xinwei, Ma, Zheng, Zhu, Yu, Sun, Wuyi, Zhu, Fengqin, Luo, Shengyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - metabolism Brain Ischemia - metabolism Cytokines - metabolism Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - metabolism Ischemic stroke Ischemic Stroke - metabolism Loureirin B Male Microglia Microglial polarization NF-kappa B - metabolism NF-κB Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction STAT6
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