Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)
Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cas...
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 2023-09, Vol.153 (5), p.979-993 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 993 |
|---|---|
| container_issue | 5 |
| container_start_page | 979 |
| container_title | International journal of cancer |
| container_volume | 153 |
| creator | Palomar-Cros, Anna Straif, Kurt Romaguera, Dora Aragonés, Nuria Castaño-Vinyals, Gemma Martin, Vicente Moreno, Victor Gómez-Acebo, Inés Guevara, Marcela Aizpurua, Amaia Molina-Barceló, Ana Jiménez-Moleón, José-Juan Tardón, Adonina Contreras-Llanes, Manuel Marcos-Gragera, Rafael Huerta, José Mª Pérez-Gómez, Beatriz Espinosa, Ana Hernández-Segura, Natalia Obón-Santacana, Mireia Alonso-Molero, Jessica Burgui, Rosana Amiano, Pilar Pinto-Carbó, Marina Olmedo-Requena, Rocio Fernández-Tardón, Guillermo Santos-Sánchez, Vanessa Fernández de Larrea-Baz, Nerea Fernández-Villa, Tania Casabonne, Delphine Dierssen-Sotos, Trinidad Ardanaz, Eva Dorronsoro, Ane Pollán, Marina Kogevinas, Manolis Lassale, Camille |
| description | Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers ( |
| doi_str_mv | 10.1002/ijc.34577 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2827263203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2837231928</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-d8da8fa0a74fb63be90263648b05a2b7ffe2e52eca729127bff42ecb0266e8323</originalsourceid><addsrcrecordid>eNpdkbtOxDAQRS0EgmWh4AeQJRq2yOJHEmdLFPGSQBRAHTnOWHhJ7GA7Qtvw7ZhnQTWamXOvZnQROqJkSQlhZ2atljwvhNhCM0pWIiOMFttolnYkE5SXe2g_hDUhlBYk30V7XHDGCRcz9F47G6ZhjMZZ7DSWYZQ-ygGwtB128Rk8TgOjjTKyx-ENIIIFH7723oSXT5WSViXQWJwE-GGU1oRnPEx9NEoGyJSz0bskj1O3wad3dZ0lyNjFAdrRsg9w-FPn6Ony4rG-zm7vr27q89tM8byKWVd1stKSSJHrtuQtrAgreZlXLSkka4XWwKBgoKRgK8pEq3WeujZRJVTp1zk6_fYdvXudIMRmMEFB30sLbgoNq5hIjozwhJ78Q9du8jZdlyguGKerVOdo8U0p70LwoJvRm0H6TUNJ8xlKk0JpvkJJ7PGP49QO0P2RvynwD6CjiCM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2837231928</pqid></control><display><type>article</type><title>Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)</title><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Palomar-Cros, Anna ; Straif, Kurt ; Romaguera, Dora ; Aragonés, Nuria ; Castaño-Vinyals, Gemma ; Martin, Vicente ; Moreno, Victor ; Gómez-Acebo, Inés ; Guevara, Marcela ; Aizpurua, Amaia ; Molina-Barceló, Ana ; Jiménez-Moleón, José-Juan ; Tardón, Adonina ; Contreras-Llanes, Manuel ; Marcos-Gragera, Rafael ; Huerta, José Mª ; Pérez-Gómez, Beatriz ; Espinosa, Ana ; Hernández-Segura, Natalia ; Obón-Santacana, Mireia ; Alonso-Molero, Jessica ; Burgui, Rosana ; Amiano, Pilar ; Pinto-Carbó, Marina ; Olmedo-Requena, Rocio ; Fernández-Tardón, Guillermo ; Santos-Sánchez, Vanessa ; Fernández de Larrea-Baz, Nerea ; Fernández-Villa, Tania ; Casabonne, Delphine ; Dierssen-Sotos, Trinidad ; Ardanaz, Eva ; Dorronsoro, Ane ; Pollán, Marina ; Kogevinas, Manolis ; Lassale, Camille</creator><creatorcontrib>Palomar-Cros, Anna ; Straif, Kurt ; Romaguera, Dora ; Aragonés, Nuria ; Castaño-Vinyals, Gemma ; Martin, Vicente ; Moreno, Victor ; Gómez-Acebo, Inés ; Guevara, Marcela ; Aizpurua, Amaia ; Molina-Barceló, Ana ; Jiménez-Moleón, José-Juan ; Tardón, Adonina ; Contreras-Llanes, Manuel ; Marcos-Gragera, Rafael ; Huerta, José Mª ; Pérez-Gómez, Beatriz ; Espinosa, Ana ; Hernández-Segura, Natalia ; Obón-Santacana, Mireia ; Alonso-Molero, Jessica ; Burgui, Rosana ; Amiano, Pilar ; Pinto-Carbó, Marina ; Olmedo-Requena, Rocio ; Fernández-Tardón, Guillermo ; Santos-Sánchez, Vanessa ; Fernández de Larrea-Baz, Nerea ; Fernández-Villa, Tania ; Casabonne, Delphine ; Dierssen-Sotos, Trinidad ; Ardanaz, Eva ; Dorronsoro, Ane ; Pollán, Marina ; Kogevinas, Manolis ; Lassale, Camille</creatorcontrib><description>Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.34577</identifier><identifier>PMID: 37323037</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Artificial sweeteners ; Beverages ; Breast cancer ; Cancer ; Chronic lymphocytic leukemia ; Colorectal cancer ; Colorectal carcinoma ; Consumers ; Diabetes ; Diabetes mellitus ; Gastric cancer ; Medical research ; Prostate cancer ; Regression analysis ; Saccharin ; Stomach ; Sucralose ; Sweeteners</subject><ispartof>International journal of cancer, 2023-09, Vol.153 (5), p.979-993</ispartof><rights>2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-d8da8fa0a74fb63be90263648b05a2b7ffe2e52eca729127bff42ecb0266e8323</citedby><cites>FETCH-LOGICAL-c348t-d8da8fa0a74fb63be90263648b05a2b7ffe2e52eca729127bff42ecb0266e8323</cites><orcidid>0000-0002-9340-2708 ; 0000-0001-8793-8314 ; 0000-0002-4299-8214 ; 0000-0002-7680-158X ; 0000-0001-7917-6145 ; 0000-0002-6127-0077 ; 0000-0003-3986-7026 ; 0000-0003-4646-3513 ; 0000-0001-5113-6475 ; 0000-0002-2818-5487 ; 0000-0003-4468-1816 ; 0000-0002-9637-3869 ; 0000-0002-9605-0461 ; 0000-0003-0054-6700 ; 0000-0002-5762-8558 ; 0000-0003-0552-2804 ; 0000-0002-5179-4475 ; 0000-0002-9049-3026 ; 0000-0002-7874-3707 ; 0000-0002-3794-1651 ; 0000-0002-4328-1565 ; 0000-0001-5150-1209 ; 0000-0001-8434-2013 ; 0000-0002-1939-8798 ; 0000-0003-0983-2156 ; 0000-0001-9824-3657 ; 0000-0002-9749-6094 ; 0000-0001-9242-6364 ; 0000-0001-8151-9290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37323037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palomar-Cros, Anna</creatorcontrib><creatorcontrib>Straif, Kurt</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>Aragonés, Nuria</creatorcontrib><creatorcontrib>Castaño-Vinyals, Gemma</creatorcontrib><creatorcontrib>Martin, Vicente</creatorcontrib><creatorcontrib>Moreno, Victor</creatorcontrib><creatorcontrib>Gómez-Acebo, Inés</creatorcontrib><creatorcontrib>Guevara, Marcela</creatorcontrib><creatorcontrib>Aizpurua, Amaia</creatorcontrib><creatorcontrib>Molina-Barceló, Ana</creatorcontrib><creatorcontrib>Jiménez-Moleón, José-Juan</creatorcontrib><creatorcontrib>Tardón, Adonina</creatorcontrib><creatorcontrib>Contreras-Llanes, Manuel</creatorcontrib><creatorcontrib>Marcos-Gragera, Rafael</creatorcontrib><creatorcontrib>Huerta, José Mª</creatorcontrib><creatorcontrib>Pérez-Gómez, Beatriz</creatorcontrib><creatorcontrib>Espinosa, Ana</creatorcontrib><creatorcontrib>Hernández-Segura, Natalia</creatorcontrib><creatorcontrib>Obón-Santacana, Mireia</creatorcontrib><creatorcontrib>Alonso-Molero, Jessica</creatorcontrib><creatorcontrib>Burgui, Rosana</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Pinto-Carbó, Marina</creatorcontrib><creatorcontrib>Olmedo-Requena, Rocio</creatorcontrib><creatorcontrib>Fernández-Tardón, Guillermo</creatorcontrib><creatorcontrib>Santos-Sánchez, Vanessa</creatorcontrib><creatorcontrib>Fernández de Larrea-Baz, Nerea</creatorcontrib><creatorcontrib>Fernández-Villa, Tania</creatorcontrib><creatorcontrib>Casabonne, Delphine</creatorcontrib><creatorcontrib>Dierssen-Sotos, Trinidad</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Dorronsoro, Ane</creatorcontrib><creatorcontrib>Pollán, Marina</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Lassale, Camille</creatorcontrib><title>Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.</description><subject>Artificial sweeteners</subject><subject>Beverages</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Chronic lymphocytic leukemia</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Consumers</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Gastric cancer</subject><subject>Medical research</subject><subject>Prostate cancer</subject><subject>Regression analysis</subject><subject>Saccharin</subject><subject>Stomach</subject><subject>Sucralose</subject><subject>Sweeteners</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkbtOxDAQRS0EgmWh4AeQJRq2yOJHEmdLFPGSQBRAHTnOWHhJ7GA7Qtvw7ZhnQTWamXOvZnQROqJkSQlhZ2atljwvhNhCM0pWIiOMFttolnYkE5SXe2g_hDUhlBYk30V7XHDGCRcz9F47G6ZhjMZZ7DSWYZQ-ygGwtB128Rk8TgOjjTKyx-ENIIIFH7723oSXT5WSViXQWJwE-GGU1oRnPEx9NEoGyJSz0bskj1O3wad3dZ0lyNjFAdrRsg9w-FPn6Ony4rG-zm7vr27q89tM8byKWVd1stKSSJHrtuQtrAgreZlXLSkka4XWwKBgoKRgK8pEq3WeujZRJVTp1zk6_fYdvXudIMRmMEFB30sLbgoNq5hIjozwhJ78Q9du8jZdlyguGKerVOdo8U0p70LwoJvRm0H6TUNJ8xlKk0JpvkJJ7PGP49QO0P2RvynwD6CjiCM</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Palomar-Cros, Anna</creator><creator>Straif, Kurt</creator><creator>Romaguera, Dora</creator><creator>Aragonés, Nuria</creator><creator>Castaño-Vinyals, Gemma</creator><creator>Martin, Vicente</creator><creator>Moreno, Victor</creator><creator>Gómez-Acebo, Inés</creator><creator>Guevara, Marcela</creator><creator>Aizpurua, Amaia</creator><creator>Molina-Barceló, Ana</creator><creator>Jiménez-Moleón, José-Juan</creator><creator>Tardón, Adonina</creator><creator>Contreras-Llanes, Manuel</creator><creator>Marcos-Gragera, Rafael</creator><creator>Huerta, José Mª</creator><creator>Pérez-Gómez, Beatriz</creator><creator>Espinosa, Ana</creator><creator>Hernández-Segura, Natalia</creator><creator>Obón-Santacana, Mireia</creator><creator>Alonso-Molero, Jessica</creator><creator>Burgui, Rosana</creator><creator>Amiano, Pilar</creator><creator>Pinto-Carbó, Marina</creator><creator>Olmedo-Requena, Rocio</creator><creator>Fernández-Tardón, Guillermo</creator><creator>Santos-Sánchez, Vanessa</creator><creator>Fernández de Larrea-Baz, Nerea</creator><creator>Fernández-Villa, Tania</creator><creator>Casabonne, Delphine</creator><creator>Dierssen-Sotos, Trinidad</creator><creator>Ardanaz, Eva</creator><creator>Dorronsoro, Ane</creator><creator>Pollán, Marina</creator><creator>Kogevinas, Manolis</creator><creator>Lassale, Camille</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9340-2708</orcidid><orcidid>https://orcid.org/0000-0001-8793-8314</orcidid><orcidid>https://orcid.org/0000-0002-4299-8214</orcidid><orcidid>https://orcid.org/0000-0002-7680-158X</orcidid><orcidid>https://orcid.org/0000-0001-7917-6145</orcidid><orcidid>https://orcid.org/0000-0002-6127-0077</orcidid><orcidid>https://orcid.org/0000-0003-3986-7026</orcidid><orcidid>https://orcid.org/0000-0003-4646-3513</orcidid><orcidid>https://orcid.org/0000-0001-5113-6475</orcidid><orcidid>https://orcid.org/0000-0002-2818-5487</orcidid><orcidid>https://orcid.org/0000-0003-4468-1816</orcidid><orcidid>https://orcid.org/0000-0002-9637-3869</orcidid><orcidid>https://orcid.org/0000-0002-9605-0461</orcidid><orcidid>https://orcid.org/0000-0003-0054-6700</orcidid><orcidid>https://orcid.org/0000-0002-5762-8558</orcidid><orcidid>https://orcid.org/0000-0003-0552-2804</orcidid><orcidid>https://orcid.org/0000-0002-5179-4475</orcidid><orcidid>https://orcid.org/0000-0002-9049-3026</orcidid><orcidid>https://orcid.org/0000-0002-7874-3707</orcidid><orcidid>https://orcid.org/0000-0002-3794-1651</orcidid><orcidid>https://orcid.org/0000-0002-4328-1565</orcidid><orcidid>https://orcid.org/0000-0001-5150-1209</orcidid><orcidid>https://orcid.org/0000-0001-8434-2013</orcidid><orcidid>https://orcid.org/0000-0002-1939-8798</orcidid><orcidid>https://orcid.org/0000-0003-0983-2156</orcidid><orcidid>https://orcid.org/0000-0001-9824-3657</orcidid><orcidid>https://orcid.org/0000-0002-9749-6094</orcidid><orcidid>https://orcid.org/0000-0001-9242-6364</orcidid><orcidid>https://orcid.org/0000-0001-8151-9290</orcidid></search><sort><creationdate>20230901</creationdate><title>Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)</title><author>Palomar-Cros, Anna ; Straif, Kurt ; Romaguera, Dora ; Aragonés, Nuria ; Castaño-Vinyals, Gemma ; Martin, Vicente ; Moreno, Victor ; Gómez-Acebo, Inés ; Guevara, Marcela ; Aizpurua, Amaia ; Molina-Barceló, Ana ; Jiménez-Moleón, José-Juan ; Tardón, Adonina ; Contreras-Llanes, Manuel ; Marcos-Gragera, Rafael ; Huerta, José Mª ; Pérez-Gómez, Beatriz ; Espinosa, Ana ; Hernández-Segura, Natalia ; Obón-Santacana, Mireia ; Alonso-Molero, Jessica ; Burgui, Rosana ; Amiano, Pilar ; Pinto-Carbó, Marina ; Olmedo-Requena, Rocio ; Fernández-Tardón, Guillermo ; Santos-Sánchez, Vanessa ; Fernández de Larrea-Baz, Nerea ; Fernández-Villa, Tania ; Casabonne, Delphine ; Dierssen-Sotos, Trinidad ; Ardanaz, Eva ; Dorronsoro, Ane ; Pollán, Marina ; Kogevinas, Manolis ; Lassale, Camille</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-d8da8fa0a74fb63be90263648b05a2b7ffe2e52eca729127bff42ecb0266e8323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Artificial sweeteners</topic><topic>Beverages</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Chronic lymphocytic leukemia</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Consumers</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Gastric cancer</topic><topic>Medical research</topic><topic>Prostate cancer</topic><topic>Regression analysis</topic><topic>Saccharin</topic><topic>Stomach</topic><topic>Sucralose</topic><topic>Sweeteners</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palomar-Cros, Anna</creatorcontrib><creatorcontrib>Straif, Kurt</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>Aragonés, Nuria</creatorcontrib><creatorcontrib>Castaño-Vinyals, Gemma</creatorcontrib><creatorcontrib>Martin, Vicente</creatorcontrib><creatorcontrib>Moreno, Victor</creatorcontrib><creatorcontrib>Gómez-Acebo, Inés</creatorcontrib><creatorcontrib>Guevara, Marcela</creatorcontrib><creatorcontrib>Aizpurua, Amaia</creatorcontrib><creatorcontrib>Molina-Barceló, Ana</creatorcontrib><creatorcontrib>Jiménez-Moleón, José-Juan</creatorcontrib><creatorcontrib>Tardón, Adonina</creatorcontrib><creatorcontrib>Contreras-Llanes, Manuel</creatorcontrib><creatorcontrib>Marcos-Gragera, Rafael</creatorcontrib><creatorcontrib>Huerta, José Mª</creatorcontrib><creatorcontrib>Pérez-Gómez, Beatriz</creatorcontrib><creatorcontrib>Espinosa, Ana</creatorcontrib><creatorcontrib>Hernández-Segura, Natalia</creatorcontrib><creatorcontrib>Obón-Santacana, Mireia</creatorcontrib><creatorcontrib>Alonso-Molero, Jessica</creatorcontrib><creatorcontrib>Burgui, Rosana</creatorcontrib><creatorcontrib>Amiano, Pilar</creatorcontrib><creatorcontrib>Pinto-Carbó, Marina</creatorcontrib><creatorcontrib>Olmedo-Requena, Rocio</creatorcontrib><creatorcontrib>Fernández-Tardón, Guillermo</creatorcontrib><creatorcontrib>Santos-Sánchez, Vanessa</creatorcontrib><creatorcontrib>Fernández de Larrea-Baz, Nerea</creatorcontrib><creatorcontrib>Fernández-Villa, Tania</creatorcontrib><creatorcontrib>Casabonne, Delphine</creatorcontrib><creatorcontrib>Dierssen-Sotos, Trinidad</creatorcontrib><creatorcontrib>Ardanaz, Eva</creatorcontrib><creatorcontrib>Dorronsoro, Ane</creatorcontrib><creatorcontrib>Pollán, Marina</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Lassale, Camille</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palomar-Cros, Anna</au><au>Straif, Kurt</au><au>Romaguera, Dora</au><au>Aragonés, Nuria</au><au>Castaño-Vinyals, Gemma</au><au>Martin, Vicente</au><au>Moreno, Victor</au><au>Gómez-Acebo, Inés</au><au>Guevara, Marcela</au><au>Aizpurua, Amaia</au><au>Molina-Barceló, Ana</au><au>Jiménez-Moleón, José-Juan</au><au>Tardón, Adonina</au><au>Contreras-Llanes, Manuel</au><au>Marcos-Gragera, Rafael</au><au>Huerta, José Mª</au><au>Pérez-Gómez, Beatriz</au><au>Espinosa, Ana</au><au>Hernández-Segura, Natalia</au><au>Obón-Santacana, Mireia</au><au>Alonso-Molero, Jessica</au><au>Burgui, Rosana</au><au>Amiano, Pilar</au><au>Pinto-Carbó, Marina</au><au>Olmedo-Requena, Rocio</au><au>Fernández-Tardón, Guillermo</au><au>Santos-Sánchez, Vanessa</au><au>Fernández de Larrea-Baz, Nerea</au><au>Fernández-Villa, Tania</au><au>Casabonne, Delphine</au><au>Dierssen-Sotos, Trinidad</au><au>Ardanaz, Eva</au><au>Dorronsoro, Ane</au><au>Pollán, Marina</au><au>Kogevinas, Manolis</au><au>Lassale, Camille</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>153</volume><issue>5</issue><spage>979</spage><epage>993</epage><pages>979-993</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37323037</pmid><doi>10.1002/ijc.34577</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-9340-2708</orcidid><orcidid>https://orcid.org/0000-0001-8793-8314</orcidid><orcidid>https://orcid.org/0000-0002-4299-8214</orcidid><orcidid>https://orcid.org/0000-0002-7680-158X</orcidid><orcidid>https://orcid.org/0000-0001-7917-6145</orcidid><orcidid>https://orcid.org/0000-0002-6127-0077</orcidid><orcidid>https://orcid.org/0000-0003-3986-7026</orcidid><orcidid>https://orcid.org/0000-0003-4646-3513</orcidid><orcidid>https://orcid.org/0000-0001-5113-6475</orcidid><orcidid>https://orcid.org/0000-0002-2818-5487</orcidid><orcidid>https://orcid.org/0000-0003-4468-1816</orcidid><orcidid>https://orcid.org/0000-0002-9637-3869</orcidid><orcidid>https://orcid.org/0000-0002-9605-0461</orcidid><orcidid>https://orcid.org/0000-0003-0054-6700</orcidid><orcidid>https://orcid.org/0000-0002-5762-8558</orcidid><orcidid>https://orcid.org/0000-0003-0552-2804</orcidid><orcidid>https://orcid.org/0000-0002-5179-4475</orcidid><orcidid>https://orcid.org/0000-0002-9049-3026</orcidid><orcidid>https://orcid.org/0000-0002-7874-3707</orcidid><orcidid>https://orcid.org/0000-0002-3794-1651</orcidid><orcidid>https://orcid.org/0000-0002-4328-1565</orcidid><orcidid>https://orcid.org/0000-0001-5150-1209</orcidid><orcidid>https://orcid.org/0000-0001-8434-2013</orcidid><orcidid>https://orcid.org/0000-0002-1939-8798</orcidid><orcidid>https://orcid.org/0000-0003-0983-2156</orcidid><orcidid>https://orcid.org/0000-0001-9824-3657</orcidid><orcidid>https://orcid.org/0000-0002-9749-6094</orcidid><orcidid>https://orcid.org/0000-0001-9242-6364</orcidid><orcidid>https://orcid.org/0000-0001-8151-9290</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2023-09, Vol.153 (5), p.979-993 |
| issn | 0020-7136 1097-0215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2827263203 |
| source | Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Artificial sweeteners Beverages Breast cancer Cancer Chronic lymphocytic leukemia Colorectal cancer Colorectal carcinoma Consumers Diabetes Diabetes mellitus Gastric cancer Medical research Prostate cancer Regression analysis Saccharin Stomach Sucralose Sweeteners |
| title | Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A09%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Consumption%20of%20aspartame%20and%20other%20artificial%20sweeteners%20and%20risk%20of%20cancer%20in%20the%20Spanish%20multicase-control%20study%20(MCC-Spain)&rft.jtitle=International%20journal%20of%20cancer&rft.au=Palomar-Cros,%20Anna&rft.date=2023-09-01&rft.volume=153&rft.issue=5&rft.spage=979&rft.epage=993&rft.pages=979-993&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.34577&rft_dat=%3Cproquest_cross%3E2837231928%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2837231928&rft_id=info:pmid/37323037&rfr_iscdi=true |